TY - JOUR
T1 - A randomised trial comparing weight loss with aerobic exercise in overweight individuals with coronary artery disease
T2 - The CUT-IT trial
AU - Pedersen, Lene Rørholm Engelbrecht
AU - Olsen, Rasmus H
AU - Jürs, Anders
AU - Astrup, Arne
AU - Chabanova, Elizaveta
AU - Simonsen, Lene
AU - Wisløff, Ulrik
AU - Haugaard, Steen B
AU - Prescott, Eva
N1 - CURIS 2015 NEXS 242
PY - 2015/8/11
Y1 - 2015/8/11
N2 - Background: We aimed to compare the effect of aerobic interval training (AIT) versus a low energy diet (LED) on physical fitness, body composition, cardiovascular risk factors and symptoms in overweight individuals with coronary artery disease (CAD). Methods and design: Seventy non-diabetic participants with CAD, a BMI>28 kg/m2 and aged 45 to 75 years were randomised to 12 weeks' AIT at 90% peak heart rate three times a week or LED (800-1000 kcal/day) for 8-10 weeks followed by 2-4 weeks' weight maintenance diet. Results: Twenty-six (74%) AIT and 29 (83%) LED participants completed intervention per protocol. VO2peak (mL/kg fat free mass0.67/min) increased by 10.4% (p=0.002) following AIT, whereas no change was observed after LED (-3.0%, p=0.095). The LED group lost 10.6% body weight and 26.6% body fat mass (p<0.001) compared to 1.6% (p=0.002) and 5.5% (p<0.001) following AIT. Waist circumference and visceral abdominal fat were reduced by both interventions but were most pronounced following LED (between-group, p<0.001). Total cholesterol, non-HDL-C and triglycerides decreased significantly in both groups whereas HDL-C and blood pressure were unchanged. Six participants had their antihypertensive treatment reduced following LED (between-group, p=0.032). Canadian Cardiovascular Society (CCS), New York Heart Association (NYHA) and anxiety scores were improved, while depressive symptoms remained unchanged. Intention-to-treat analyses including 65 participants (93%) were similar to per protocol analysis. Conclusion: Both interventions were feasible and effective in achieving the desired effects. LED was superior in improving body composition and blood pressure, whereas effects on lipids and symptoms were similar in the two groups. Thus, both AIT and LED improve the cardiovascular risk profile in overweight individuals with contemporarily treated CAD.
AB - Background: We aimed to compare the effect of aerobic interval training (AIT) versus a low energy diet (LED) on physical fitness, body composition, cardiovascular risk factors and symptoms in overweight individuals with coronary artery disease (CAD). Methods and design: Seventy non-diabetic participants with CAD, a BMI>28 kg/m2 and aged 45 to 75 years were randomised to 12 weeks' AIT at 90% peak heart rate three times a week or LED (800-1000 kcal/day) for 8-10 weeks followed by 2-4 weeks' weight maintenance diet. Results: Twenty-six (74%) AIT and 29 (83%) LED participants completed intervention per protocol. VO2peak (mL/kg fat free mass0.67/min) increased by 10.4% (p=0.002) following AIT, whereas no change was observed after LED (-3.0%, p=0.095). The LED group lost 10.6% body weight and 26.6% body fat mass (p<0.001) compared to 1.6% (p=0.002) and 5.5% (p<0.001) following AIT. Waist circumference and visceral abdominal fat were reduced by both interventions but were most pronounced following LED (between-group, p<0.001). Total cholesterol, non-HDL-C and triglycerides decreased significantly in both groups whereas HDL-C and blood pressure were unchanged. Six participants had their antihypertensive treatment reduced following LED (between-group, p=0.032). Canadian Cardiovascular Society (CCS), New York Heart Association (NYHA) and anxiety scores were improved, while depressive symptoms remained unchanged. Intention-to-treat analyses including 65 participants (93%) were similar to per protocol analysis. Conclusion: Both interventions were feasible and effective in achieving the desired effects. LED was superior in improving body composition and blood pressure, whereas effects on lipids and symptoms were similar in the two groups. Thus, both AIT and LED improve the cardiovascular risk profile in overweight individuals with contemporarily treated CAD.
U2 - 10.1177/2047487314545280
DO - 10.1177/2047487314545280
M3 - Journal article
C2 - 25082954
SN - 2047-4873
VL - 22
SP - 1009
EP - 1017
JO - European Journal of Preventive Cardiology
JF - European Journal of Preventive Cardiology
IS - 8
ER -
