A protein diet score, including plant and animal protein, investigating the association with HbA1c and eGFR - the PREVIEW project

TY - JOUR

T1 - A protein diet score, including plant and animal protein, investigating the association with HbA1c and eGFR - the PREVIEW project

AU - Møller, Grith

AU - Sluik, Diewertje

AU - Ritz, Christian

AU - Mikkilä, Vera

AU - Raitakari, Olli T

AU - Hutri-Kähönen, Nina

AU - Dragsted, Lars Ove

AU - Larsen, Thomas Meinert

AU - Poppitt, Sally D

AU - Silvestre, Marta P

AU - Feskens, Edith J M

AU - Brand-Miller, Jennie

AU - Raben, Anne

N1 - CURIS 2017 NEXS 206

PY - 2017/7/17

Y1 - 2017/7/17

N2 - Higher-protein diets have been advocated for body-weight regulation for the past few decades. However, the potential health risks of these diets are still uncertain. We aimed to develop a protein score based on the quantity and source of protein, and to examine the association of the score with glycated haemoglobin (HbA1c) and estimated glomerular filtration rate (eGFR). Analyses were based on three population studies included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World): NQplus, Lifelines, and the Young Finns Study. Cross-sectional data from food-frequency questionnaires (n = 76,777 subjects) were used to develop a protein score consisting of two components: 1) percentage of energy from total protein, and 2) plant to animal protein ratio. An inverse association between protein score and HbA1c (slope -0.02 ± 0.01 mmol/mol, p < 0.001) was seen in Lifelines. We found a positive association between the protein score and eGFR in Lifelines (slope 0.17 ± 0.02 mL/min/1.73 m², p < 0.0001). Protein scoring might be a useful tool to assess both the effect of quantity and source of protein on health parameters. Further studies are needed to validate this newly developed protein score.

AB - Higher-protein diets have been advocated for body-weight regulation for the past few decades. However, the potential health risks of these diets are still uncertain. We aimed to develop a protein score based on the quantity and source of protein, and to examine the association of the score with glycated haemoglobin (HbA1c) and estimated glomerular filtration rate (eGFR). Analyses were based on three population studies included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World): NQplus, Lifelines, and the Young Finns Study. Cross-sectional data from food-frequency questionnaires (n = 76,777 subjects) were used to develop a protein score consisting of two components: 1) percentage of energy from total protein, and 2) plant to animal protein ratio. An inverse association between protein score and HbA1c (slope -0.02 ± 0.01 mmol/mol, p < 0.001) was seen in Lifelines. We found a positive association between the protein score and eGFR in Lifelines (slope 0.17 ± 0.02 mL/min/1.73 m², p < 0.0001). Protein scoring might be a useful tool to assess both the effect of quantity and source of protein on health parameters. Further studies are needed to validate this newly developed protein score.

KW - Protein diet score

KW - HbA1c

KW - eGFR

KW - Healthy subjects

KW - Population studies

U2 - 10.3390/nu9070763

DO - 10.3390/nu9070763

M3 - Journal article

C2 - 28714926

SN - 2072-6643

VL - 9

JO - Nutrients

JF - Nutrients

IS - 7

M1 - 763

ER -