A prospective study of PET/CT in initial staging of small-cell lung cancer: comparison with CT, bone scintigraphy and bone marrow analysis

B M Fischer; J Mortensen; S W Langer; A Loft; A K Berthelsen; B I Petersen; G Daugaard; U Lassen; H H Hansen

doi:10.1093/annonc/mdl374

A prospective study of PET/CT in initial staging of small-cell lung cancer: comparison with CT, bone scintigraphy and bone marrow analysis

B M Fischer, J Mortensen, S W Langer, A Loft, A K Berthelsen, B I Petersen, G Daugaard, U Lassen, H H Hansen

112 Citations (Scopus)

Abstract

BACKGROUND: Small-cell lung cancer (SCLC) accounts for 15%-20% of all lung cancer cases. Accurate and fast staging is mandatory when choosing treatment, but current staging procedures are time consuming and lack sensitivity.

PATIENTS AND METHODS: A prospective study was designed to examine the role of combined positron emission tomography/computed tomography (PET/CT) compared with standard staging (CT, bone scintigraphy and immunocytochemical assessment of bone marrow biopsy) of patients with SCLC. Thirty-four consecutive patients were included. Twenty-nine patients received initial PET/CT.

RESULTS: PET/CT caused change of stage in 5/29 (17%). Excluding patients with unconfirmed findings or pleural effusion, the sensitivity for accurate staging of patients with extensive disease was the following: for standard staging 79%, PET 93% and PET/CT 93%. Specificity was 100%, 83% and 100%, respectively.

CONCLUSION: The results from this first study on PET/CT in SCLC indicates that PET/CT can simplify and perhaps even improve the accuracy of the current staging procedure in SCLC. A larger clinical trial, preferably with consequent histological confirmation in case of discordance, however, is warranted.

Original language	English
Journal	Annals of oncology : official journal of the European Society for Medical Oncology / ESMO
Volume	18
Issue number	2
Pages (from-to)	338-45
Number of pages	8
ISSN	0923-7534
DOIs	https://doi.org/10.1093/annonc/mdl374
Publication status	Published - Feb 2007

Keywords

Aged
Bone Marrow
Bone Neoplasms
Carcinoma, Small Cell
Female
Fluorodeoxyglucose F18
Humans
Lung Neoplasms
Male
Middle Aged
Neoplasm Staging
Positron-Emission Tomography
Prospective Studies
Radiopharmaceuticals
Sensitivity and Specificity
Tomography, X-Ray Computed
Comparative Study
Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/annonc/mdl374

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Fischer, B. M., Mortensen, J., Langer, S. W., Loft, A., Berthelsen, A. K., Petersen, B. I., Daugaard, G., Lassen, U., & Hansen, H. H. (2007). A prospective study of PET/CT in initial staging of small-cell lung cancer: comparison with CT, bone scintigraphy and bone marrow analysis. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, 18(2), 338-45. https://doi.org/10.1093/annonc/mdl374

A prospective study of PET/CT in initial staging of small-cell lung cancer : comparison with CT, bone scintigraphy and bone marrow analysis. / Fischer, B M; Mortensen, J; Langer, S W et al.

In: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, Vol. 18, No. 2, 02.2007, p. 338-45.

Research output: Contribution to journal › Journal article › Research › peer-review

Fischer, BM, Mortensen, J, Langer, SW, Loft, A, Berthelsen, AK, Petersen, BI, Daugaard, G , Lassen, U & Hansen, HH 2007, 'A prospective study of PET/CT in initial staging of small-cell lung cancer: comparison with CT, bone scintigraphy and bone marrow analysis', Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, vol. 18, no. 2, pp. 338-45. https://doi.org/10.1093/annonc/mdl374

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abstract = "BACKGROUND: Small-cell lung cancer (SCLC) accounts for 15%-20% of all lung cancer cases. Accurate and fast staging is mandatory when choosing treatment, but current staging procedures are time consuming and lack sensitivity.PATIENTS AND METHODS: A prospective study was designed to examine the role of combined positron emission tomography/computed tomography (PET/CT) compared with standard staging (CT, bone scintigraphy and immunocytochemical assessment of bone marrow biopsy) of patients with SCLC. Thirty-four consecutive patients were included. Twenty-nine patients received initial PET/CT.RESULTS: PET/CT caused change of stage in 5/29 (17%). Excluding patients with unconfirmed findings or pleural effusion, the sensitivity for accurate staging of patients with extensive disease was the following: for standard staging 79%, PET 93% and PET/CT 93%. Specificity was 100%, 83% and 100%, respectively.CONCLUSION: The results from this first study on PET/CT in SCLC indicates that PET/CT can simplify and perhaps even improve the accuracy of the current staging procedure in SCLC. A larger clinical trial, preferably with consequent histological confirmation in case of discordance, however, is warranted.",

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AU - Fischer, B M

AU - Mortensen, J

AU - Langer, S W

AU - Loft, A

AU - Berthelsen, A K

AU - Petersen, B I

AU - Daugaard, G

AU - Lassen, U

AU - Hansen, H H

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N2 - BACKGROUND: Small-cell lung cancer (SCLC) accounts for 15%-20% of all lung cancer cases. Accurate and fast staging is mandatory when choosing treatment, but current staging procedures are time consuming and lack sensitivity.PATIENTS AND METHODS: A prospective study was designed to examine the role of combined positron emission tomography/computed tomography (PET/CT) compared with standard staging (CT, bone scintigraphy and immunocytochemical assessment of bone marrow biopsy) of patients with SCLC. Thirty-four consecutive patients were included. Twenty-nine patients received initial PET/CT.RESULTS: PET/CT caused change of stage in 5/29 (17%). Excluding patients with unconfirmed findings or pleural effusion, the sensitivity for accurate staging of patients with extensive disease was the following: for standard staging 79%, PET 93% and PET/CT 93%. Specificity was 100%, 83% and 100%, respectively.CONCLUSION: The results from this first study on PET/CT in SCLC indicates that PET/CT can simplify and perhaps even improve the accuracy of the current staging procedure in SCLC. A larger clinical trial, preferably with consequent histological confirmation in case of discordance, however, is warranted.

AB - BACKGROUND: Small-cell lung cancer (SCLC) accounts for 15%-20% of all lung cancer cases. Accurate and fast staging is mandatory when choosing treatment, but current staging procedures are time consuming and lack sensitivity.PATIENTS AND METHODS: A prospective study was designed to examine the role of combined positron emission tomography/computed tomography (PET/CT) compared with standard staging (CT, bone scintigraphy and immunocytochemical assessment of bone marrow biopsy) of patients with SCLC. Thirty-four consecutive patients were included. Twenty-nine patients received initial PET/CT.RESULTS: PET/CT caused change of stage in 5/29 (17%). Excluding patients with unconfirmed findings or pleural effusion, the sensitivity for accurate staging of patients with extensive disease was the following: for standard staging 79%, PET 93% and PET/CT 93%. Specificity was 100%, 83% and 100%, respectively.CONCLUSION: The results from this first study on PET/CT in SCLC indicates that PET/CT can simplify and perhaps even improve the accuracy of the current staging procedure in SCLC. A larger clinical trial, preferably with consequent histological confirmation in case of discordance, however, is warranted.

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A prospective study of PET/CT in initial staging of small-cell lung cancer: comparison with CT, bone scintigraphy and bone marrow analysis

Abstract

Keywords

UN SDGs

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