A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature

Matthias Manne Knopp; Natasha Gannon; Ilona Porsch; Malte Bille Rask; Niels Erik Olesen; Peter Langguth; René Holm; Thomas Rades

doi:10.1016/j.xphs.2016.02.017

A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature

Matthias Manne Knopp, Natasha Gannon, Ilona Porsch, Malte Bille Rask, Niels Erik Olesen, Peter Langguth, René Holm, Thomas Rades

14 Citations (Scopus)

Abstract

The established methods to predict drug-polymer solubility at room temperature either rely on extrapolation over a long temperature range or are limited by the availability of a liquid analogue of the polymer. To overcome these issues, this work investigated a new methodology where the drug-polymer solubility is estimated from the solubility of the drug in a solution of the polymer at room temperature using the shake-flask method. Thus, the new polymer in solution method does not rely on temperature extrapolations and only requires the polymer and a solvent, in which the polymer is soluble, that does not affect the molecular structure of the drug and polymer relative to that in the solid state. Consequently, as this method has the potential to provide fast and precise estimates of drug-polymer solubility at room temperature, we encourage the scientific community to further investigate this principle both fundamentally and practically.

Original language	English
Journal	Journal of Pharmaceutical Sciences
Volume	105
Issue number	9
Pages (from-to)	2621-2624
Number of pages	4
ISSN	0022-3549
DOIs	https://doi.org/10.1016/j.xphs.2016.02.017
Publication status	Published - 1 Sept 2016

Keywords

Journal Article

Access to Document

10.1016/j.xphs.2016.02.017

Cite this

@article{cd3d21c5504045c8bd3af1d94b5a44b3,

title = "A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature",

abstract = "The established methods to predict drug-polymer solubility at room temperature either rely on extrapolation over a long temperature range or are limited by the availability of a liquid analogue of the polymer. To overcome these issues, this work investigated a new methodology where the drug-polymer solubility is estimated from the solubility of the drug in a solution of the polymer at room temperature using the shake-flask method. Thus, the new polymer in solution method does not rely on temperature extrapolations and only requires the polymer and a solvent, in which the polymer is soluble, that does not affect the molecular structure of the drug and polymer relative to that in the solid state. Consequently, as this method has the potential to provide fast and precise estimates of drug-polymer solubility at room temperature, we encourage the scientific community to further investigate this principle both fundamentally and practically.",

keywords = "Journal Article",

author = "Knopp, {Matthias Manne} and Natasha Gannon and Ilona Porsch and Rask, {Malte Bille} and Olesen, {Niels Erik} and Peter Langguth and Ren{\'e} Holm and Thomas Rades",

year = "2016",

month = sep,

day = "1",

doi = "10.1016/j.xphs.2016.02.017",

language = "English",

volume = "105",

pages = "2621--2624",

journal = "Journal of Pharmaceutical Sciences",

issn = "0022-3549",

publisher = "Elsevier",

number = "9",

}

TY - JOUR

T1 - A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature

AU - Knopp, Matthias Manne

AU - Gannon, Natasha

AU - Porsch, Ilona

AU - Rask, Malte Bille

AU - Olesen, Niels Erik

AU - Langguth, Peter

AU - Holm, René

AU - Rades, Thomas

PY - 2016/9/1

Y1 - 2016/9/1

N2 - The established methods to predict drug-polymer solubility at room temperature either rely on extrapolation over a long temperature range or are limited by the availability of a liquid analogue of the polymer. To overcome these issues, this work investigated a new methodology where the drug-polymer solubility is estimated from the solubility of the drug in a solution of the polymer at room temperature using the shake-flask method. Thus, the new polymer in solution method does not rely on temperature extrapolations and only requires the polymer and a solvent, in which the polymer is soluble, that does not affect the molecular structure of the drug and polymer relative to that in the solid state. Consequently, as this method has the potential to provide fast and precise estimates of drug-polymer solubility at room temperature, we encourage the scientific community to further investigate this principle both fundamentally and practically.

AB - The established methods to predict drug-polymer solubility at room temperature either rely on extrapolation over a long temperature range or are limited by the availability of a liquid analogue of the polymer. To overcome these issues, this work investigated a new methodology where the drug-polymer solubility is estimated from the solubility of the drug in a solution of the polymer at room temperature using the shake-flask method. Thus, the new polymer in solution method does not rely on temperature extrapolations and only requires the polymer and a solvent, in which the polymer is soluble, that does not affect the molecular structure of the drug and polymer relative to that in the solid state. Consequently, as this method has the potential to provide fast and precise estimates of drug-polymer solubility at room temperature, we encourage the scientific community to further investigate this principle both fundamentally and practically.

KW - Journal Article

U2 - 10.1016/j.xphs.2016.02.017

DO - 10.1016/j.xphs.2016.02.017

M3 - Journal article

C2 - 27012222

SN - 0022-3549

VL - 105

SP - 2621

EP - 2624

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

IS - 9

ER -

A Promising New Method to Estimate Drug-Polymer Solubility at Room Temperature

Abstract

Keywords

Access to Document

Fingerprint

Cite this