A prevalent amino acid polymorphism at codon 98 (Ala98Val) of the hepatocyte nuclear factor-1alpha is associated with maturity-onset diabetes of the young and younger age at onset of type 2 diabetes in Asian Indians

Shekher Anuradha; Venkatesan Radha; Raj Deepa; Torben Hansen; Bendix Carstensen; Oluf Pedersen; Viswanathan Mohan

A prevalent amino acid polymorphism at codon 98 (Ala98Val) of the hepatocyte nuclear factor-1alpha is associated with maturity-onset diabetes of the young and younger age at onset of type 2 diabetes in Asian Indians

Shekher Anuradha, Venkatesan Radha, Raj Deepa, Torben Hansen, Bendix Carstensen, Oluf Pedersen, Viswanathan Mohan

Department of Public Health

38 Citations (Scopus)

Abstract

Among Europeans, mutations in the hepatocyte nuclear factor-1alpha (HNF1alpha) gene are associated with the most common form of maturity-onset diabetes of the young (MODY)3. In Asian Indians, type 2 diabetes occurs earlier and often overlaps with MODY, but the genetics of the latter are unknown. The aim of this study was to estimate the prevalence of Ala98Val polymorphism of the HNF1alpha gene in different types of diabetes in Asian Indians.

Original language	English
Journal	Diabetes Care
Volume	28
Issue number	10
Pages (from-to)	2430-5
Number of pages	6
ISSN	0149-5992
Publication status	Published - 2005

Keywords

Adolescent
Adult
Age Distribution
Age of Onset
Asian Continental Ancestry Group
Child
Diabetes Mellitus, Type 2
Genetic Predisposition to Disease
Hepatocyte Nuclear Factor 1-alpha
Humans
India
Middle Aged
Polymorphism, Single Nucleotide
Prevalence

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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A prevalent amino acid polymorphism at codon 98 (Ala98Val) of the hepatocyte nuclear factor-1alpha is associated with maturity-onset diabetes of the young and younger age at onset of type 2 diabetes in Asian Indians. / Anuradha, Shekher; Radha, Venkatesan; Deepa, Raj et al.

In: Diabetes Care, Vol. 28, No. 10, 2005, p. 2430-5.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "Among Europeans, mutations in the hepatocyte nuclear factor-1alpha (HNF1alpha) gene are associated with the most common form of maturity-onset diabetes of the young (MODY)3. In Asian Indians, type 2 diabetes occurs earlier and often overlaps with MODY, but the genetics of the latter are unknown. The aim of this study was to estimate the prevalence of Ala98Val polymorphism of the HNF1alpha gene in different types of diabetes in Asian Indians.",

keywords = "Adolescent, Adult, Age Distribution, Age of Onset, Asian Continental Ancestry Group, Child, Diabetes Mellitus, Type 2, Genetic Predisposition to Disease, Hepatocyte Nuclear Factor 1-alpha, Humans, India, Middle Aged, Polymorphism, Single Nucleotide, Prevalence",

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T1 - A prevalent amino acid polymorphism at codon 98 (Ala98Val) of the hepatocyte nuclear factor-1alpha is associated with maturity-onset diabetes of the young and younger age at onset of type 2 diabetes in Asian Indians

AU - Anuradha, Shekher

AU - Radha, Venkatesan

AU - Deepa, Raj

AU - Hansen, Torben

AU - Carstensen, Bendix

AU - Pedersen, Oluf

AU - Mohan, Viswanathan

PY - 2005

Y1 - 2005

N2 - Among Europeans, mutations in the hepatocyte nuclear factor-1alpha (HNF1alpha) gene are associated with the most common form of maturity-onset diabetes of the young (MODY)3. In Asian Indians, type 2 diabetes occurs earlier and often overlaps with MODY, but the genetics of the latter are unknown. The aim of this study was to estimate the prevalence of Ala98Val polymorphism of the HNF1alpha gene in different types of diabetes in Asian Indians.

AB - Among Europeans, mutations in the hepatocyte nuclear factor-1alpha (HNF1alpha) gene are associated with the most common form of maturity-onset diabetes of the young (MODY)3. In Asian Indians, type 2 diabetes occurs earlier and often overlaps with MODY, but the genetics of the latter are unknown. The aim of this study was to estimate the prevalence of Ala98Val polymorphism of the HNF1alpha gene in different types of diabetes in Asian Indians.

KW - Adolescent

KW - Adult

KW - Age Distribution

KW - Age of Onset

KW - Asian Continental Ancestry Group

KW - Child

KW - Diabetes Mellitus, Type 2

KW - Genetic Predisposition to Disease

KW - Hepatocyte Nuclear Factor 1-alpha

KW - Humans

KW - India

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Prevalence

M3 - Journal article

C2 - 16186275

SN - 0149-5992

VL - 28

SP - 2430

EP - 2435

JO - Diabetes Care

JF - Diabetes Care

IS - 10

ER -