A Perspective on the Müller Cell-Neuron Metabolic Partnership in the Inner Retina

A K Toft-Kehler; D M Skytt; Miriam Kolko

doi:10.1007/s12035-017-0760-7

A Perspective on the Müller Cell-Neuron Metabolic Partnership in the Inner Retina

A K Toft-Kehler, D M Skytt, Miriam Kolko

9 Citations (Scopus)

Abstract

The Müller cells represent the predominant macroglial cell in the retina. In recent decades, Müller cells have been acknowledged to be far more influential on neuronal homeostasis in the retina than previously assumed. With its unique localization, spanning the entire retina being interposed between the vessels and neurons, Müller cells are responsible for the functional and metabolic support of the surrounding neurons. As a consequence of major energy demands in the retina, high levels of glucose are consumed and processed by Müller cells. The present review provides a perspective on the symbiotic relationship between Müller cells and inner retinal neurons on a cellular level by emphasizing the essential role of energy metabolism within Müller cells in relation to retinal neuron survival.

Original language	English
Journal	Molecular Neurobiology
Volume	55
Issue number	6
Pages (from-to)	5353–5361
ISSN	0893-7648
DOIs	https://doi.org/10.1007/s12035-017-0760-7
Publication status	Published - 1 Jun 2018

Keywords

Journal Article
Review

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10.1007/s12035-017-0760-7

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title = "A Perspective on the M{\"u}ller Cell-Neuron Metabolic Partnership in the Inner Retina",

abstract = "The M{\"u}ller cells represent the predominant macroglial cell in the retina. In recent decades, M{\"u}ller cells have been acknowledged to be far more influential on neuronal homeostasis in the retina than previously assumed. With its unique localization, spanning the entire retina being interposed between the vessels and neurons, M{\"u}ller cells are responsible for the functional and metabolic support of the surrounding neurons. As a consequence of major energy demands in the retina, high levels of glucose are consumed and processed by M{\"u}ller cells. The present review provides a perspective on the symbiotic relationship between M{\"u}ller cells and inner retinal neurons on a cellular level by emphasizing the essential role of energy metabolism within M{\"u}ller cells in relation to retinal neuron survival.",

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AU - Toft-Kehler, A K

AU - Skytt, D M

AU - Kolko, Miriam

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Y1 - 2018/6/1

N2 - The Müller cells represent the predominant macroglial cell in the retina. In recent decades, Müller cells have been acknowledged to be far more influential on neuronal homeostasis in the retina than previously assumed. With its unique localization, spanning the entire retina being interposed between the vessels and neurons, Müller cells are responsible for the functional and metabolic support of the surrounding neurons. As a consequence of major energy demands in the retina, high levels of glucose are consumed and processed by Müller cells. The present review provides a perspective on the symbiotic relationship between Müller cells and inner retinal neurons on a cellular level by emphasizing the essential role of energy metabolism within Müller cells in relation to retinal neuron survival.

AB - The Müller cells represent the predominant macroglial cell in the retina. In recent decades, Müller cells have been acknowledged to be far more influential on neuronal homeostasis in the retina than previously assumed. With its unique localization, spanning the entire retina being interposed between the vessels and neurons, Müller cells are responsible for the functional and metabolic support of the surrounding neurons. As a consequence of major energy demands in the retina, high levels of glucose are consumed and processed by Müller cells. The present review provides a perspective on the symbiotic relationship between Müller cells and inner retinal neurons on a cellular level by emphasizing the essential role of energy metabolism within Müller cells in relation to retinal neuron survival.

KW - Journal Article

KW - Review

U2 - 10.1007/s12035-017-0760-7

DO - 10.1007/s12035-017-0760-7

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SP - 5353

EP - 5361

JO - Molecular Neurobiology

JF - Molecular Neurobiology

IS - 6

ER -

A Perspective on the Müller Cell-Neuron Metabolic Partnership in the Inner Retina

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