A pentavalent vaccine for rainbow trout in Danish aquaculture

Moonika H. Marana; Dagoberto Sepúlveda; Defang Chen; Azmi Al-Jubury; Rzgar M. Jaafar; Per W. Kania; Niels Henrik Henriksen; Bjørn Krossøy; Inger Dalsgaard; Niels Lorenzen; Kurt Buchmann

doi:10.1016/j.fsi.2019.03.001

A pentavalent vaccine for rainbow trout in Danish aquaculture

Moonika H. Marana^*, Dagoberto Sepúlveda, Defang Chen, Azmi Al-Jubury, Rzgar M. Jaafar, Per W. Kania, Niels Henrik Henriksen, Bjørn Krossøy, Inger Dalsgaard, Niels Lorenzen, Kurt Buchmann

^*Corresponding author for this work

7 Citations (Scopus)

Abstract

Mariculture in Denmark is based on production of rainbow trout grown two years in fresh water followed by one growth season in sea cages. Although the majority of rainbow trout are vaccinated against the most serious bacterial pathogens – Aeromonas salmonicida subsp. salmonicida, Vibrio anguillarum and Yersinia ruckeri, by the use of commercially available vaccines, disease outbreaks requiring treatment with antibiotics still occur. The present study tested the potential of a new experimental multicomponent vaccine that is based on local bacterial strains, isolated from rainbow trout in Danish waters, and thus custom-designed for Danish rainbow trout mariculture. The vaccination with the multicomponent vaccine resulted in protection against three relevant bacterial diseases (yersiniosis, furunculosis, vibriosis) under experimental conditions. We showed that i.p. injection of the vaccine induced specific antibody responses in trout against the different bacterial antigens and regulated expression of genes encoding SAA, C3, IL-1β, IL-6, IL-8, IgD and MHCII.

Original language	English
Journal	Fish and Shellfish Immunology
Volume	88
Pages (from-to)	344-351
Number of pages	8
ISSN	1050-4648
DOIs	https://doi.org/10.1016/j.fsi.2019.03.001
Publication status	Published - 2019

Keywords

Aeromonas salmonicida subsp. salmonicida
Aquaculture
Rainbow trout
Vaccination
Vibrio anguillarum
Yersinia ruckeri

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.fsi.2019.03.001

Cite this

@article{8e82067c4a304cc7bc30220f89a5e04a,

title = "A pentavalent vaccine for rainbow trout in Danish aquaculture",

abstract = "Mariculture in Denmark is based on production of rainbow trout grown two years in fresh water followed by one growth season in sea cages. Although the majority of rainbow trout are vaccinated against the most serious bacterial pathogens – Aeromonas salmonicida subsp. salmonicida, Vibrio anguillarum and Yersinia ruckeri, by the use of commercially available vaccines, disease outbreaks requiring treatment with antibiotics still occur. The present study tested the potential of a new experimental multicomponent vaccine that is based on local bacterial strains, isolated from rainbow trout in Danish waters, and thus custom-designed for Danish rainbow trout mariculture. The vaccination with the multicomponent vaccine resulted in protection against three relevant bacterial diseases (yersiniosis, furunculosis, vibriosis) under experimental conditions. We showed that i.p. injection of the vaccine induced specific antibody responses in trout against the different bacterial antigens and regulated expression of genes encoding SAA, C3, IL-1β, IL-6, IL-8, IgD and MHCII.",

keywords = "Aeromonas salmonicida subsp. salmonicida, Aquaculture, Rainbow trout, Vaccination, Vibrio anguillarum, Yersinia ruckeri",

author = "Marana, {Moonika H.} and Dagoberto Sep{\'u}lveda and Defang Chen and Azmi Al-Jubury and Jaafar, {Rzgar M.} and Kania, {Per W.} and Henriksen, {Niels Henrik} and Bj{\o}rn Kross{\o}y and Inger Dalsgaard and Niels Lorenzen and Kurt Buchmann",

year = "2019",

doi = "10.1016/j.fsi.2019.03.001",

language = "English",

volume = "88",

pages = "344--351",

journal = "Fish and Shellfish Immunology",

issn = "1050-4648",

publisher = "Academic Press",

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TY - JOUR

T1 - A pentavalent vaccine for rainbow trout in Danish aquaculture

AU - Marana, Moonika H.

AU - Sepúlveda, Dagoberto

AU - Chen, Defang

AU - Al-Jubury, Azmi

AU - Jaafar, Rzgar M.

AU - Kania, Per W.

AU - Henriksen, Niels Henrik

AU - Krossøy, Bjørn

AU - Dalsgaard, Inger

AU - Lorenzen, Niels

AU - Buchmann, Kurt

PY - 2019

Y1 - 2019

N2 - Mariculture in Denmark is based on production of rainbow trout grown two years in fresh water followed by one growth season in sea cages. Although the majority of rainbow trout are vaccinated against the most serious bacterial pathogens – Aeromonas salmonicida subsp. salmonicida, Vibrio anguillarum and Yersinia ruckeri, by the use of commercially available vaccines, disease outbreaks requiring treatment with antibiotics still occur. The present study tested the potential of a new experimental multicomponent vaccine that is based on local bacterial strains, isolated from rainbow trout in Danish waters, and thus custom-designed for Danish rainbow trout mariculture. The vaccination with the multicomponent vaccine resulted in protection against three relevant bacterial diseases (yersiniosis, furunculosis, vibriosis) under experimental conditions. We showed that i.p. injection of the vaccine induced specific antibody responses in trout against the different bacterial antigens and regulated expression of genes encoding SAA, C3, IL-1β, IL-6, IL-8, IgD and MHCII.

AB - Mariculture in Denmark is based on production of rainbow trout grown two years in fresh water followed by one growth season in sea cages. Although the majority of rainbow trout are vaccinated against the most serious bacterial pathogens – Aeromonas salmonicida subsp. salmonicida, Vibrio anguillarum and Yersinia ruckeri, by the use of commercially available vaccines, disease outbreaks requiring treatment with antibiotics still occur. The present study tested the potential of a new experimental multicomponent vaccine that is based on local bacterial strains, isolated from rainbow trout in Danish waters, and thus custom-designed for Danish rainbow trout mariculture. The vaccination with the multicomponent vaccine resulted in protection against three relevant bacterial diseases (yersiniosis, furunculosis, vibriosis) under experimental conditions. We showed that i.p. injection of the vaccine induced specific antibody responses in trout against the different bacterial antigens and regulated expression of genes encoding SAA, C3, IL-1β, IL-6, IL-8, IgD and MHCII.

KW - Aeromonas salmonicida subsp. salmonicida

KW - Aquaculture

KW - Rainbow trout

KW - Vaccination

KW - Vibrio anguillarum

KW - Yersinia ruckeri

U2 - 10.1016/j.fsi.2019.03.001

DO - 10.1016/j.fsi.2019.03.001

M3 - Journal article

C2 - 30851449

AN - SCOPUS:85062677948

SN - 1050-4648

VL - 88

SP - 344

EP - 351

JO - Fish and Shellfish Immunology

JF - Fish and Shellfish Immunology

ER -

A pentavalent vaccine for rainbow trout in Danish aquaculture

Abstract

Keywords

UN SDGs

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