A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study

Nikos Papadimitriou; David Muller; Piet A. van den Brandt; Milan Geybels; Chirag J. Patel; Marc J. Gunter; David S. Lopez; Timothy J. Key; Aurora Perez-Cornago; Pietro Ferrari; Paolo Vineis; Elisabete Weiderpass; Heiner Boeing; Antonio Agudo; Maria-Jose Sanchez; Kim Overvad; Tilman Kuehn; Renee T. Fortner; Domenico Palli; Isabel Drake; Anders Bjartell; Carmen Santiuste; Bas H. Bueno-de-Mesquita; Vittorio Krogh; Anne Tjønneland; Dorthe Furstrand Lauritzen; Aurelio Barricarte Gurrea; Jose Ramon Quiros; Par Stattin; Antonia Trichopoulou; Georgia Martimianaki; Anna Karakatsani; Elin Thysell; Ingegerd Johansson; Fulvio Ricceri; Rosario Tumino; Nerea Larranaga; Kay Tee Khaw; Elio Riboli; Ioanna Tzoulaki; Konstantinos K. Tsilidis

doi:10.1007/s00394-019-02132-z

A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study

Nikos Papadimitriou, David Muller, Piet A. van den Brandt, Milan Geybels, Chirag J. Patel, Marc J. Gunter, David S. Lopez, Timothy J. Key, Aurora Perez-Cornago, Pietro Ferrari, Paolo Vineis, Elisabete Weiderpass, Heiner Boeing, Antonio Agudo, Maria-Jose Sanchez, Kim Overvad, Tilman Kuehn, Renee T. Fortner, Domenico Palli, Isabel DrakeAnders Bjartell, Carmen Santiuste, Bas H. Bueno-de-Mesquita, Vittorio Krogh, Anne Tjønneland, Dorthe Furstrand Lauritzen, Aurelio Barricarte Gurrea, Jose Ramon Quiros, Par Stattin, Antonia Trichopoulou, Georgia Martimianaki, Anna Karakatsani, Elin Thysell, Ingegerd Johansson, Fulvio Ricceri, Rosario Tumino, Nerea Larranaga, Kay Tee Khaw, Elio Riboli, Ioanna Tzoulaki, Konstantinos K. Tsilidis

1 Citation (Scopus)

Abstract

Purpose: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. Methods: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR ' 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS). Results: A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS. Conclusions: Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature.

Original language	English
Journal	European Journal of Nutrition
ISSN	1436-6207
DOIs	https://doi.org/10.1007/s00394-019-02132-z
Publication status	Published - 1 Oct 2020

Keywords

Diet
Nutrition
Epidemiology
Cohort study
Prostate cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Papadimitriou, N., Muller, D., van den Brandt, P. A., Geybels, M., Patel, C. J., Gunter, M. J., Lopez, D. S., Key, T. J., Perez-Cornago, A., Ferrari, P., Vineis, P., Weiderpass, E., Boeing, H., Agudo, A., Sanchez, M-J., Overvad, K., Kuehn, T., Fortner, R. T., Palli, D., ... Tsilidis, K. K. (2020). A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study. European Journal of Nutrition. https://doi.org/10.1007/s00394-019-02132-z

Papadimitriou, N, Muller, D, van den Brandt, PA, Geybels, M, Patel, CJ, Gunter, MJ, Lopez, DS, Key, TJ, Perez-Cornago, A, Ferrari, P, Vineis, P, Weiderpass, E, Boeing, H, Agudo, A, Sanchez, M-J, Overvad, K, Kuehn, T, Fortner, RT, Palli, D, Drake, I, Bjartell, A, Santiuste, C, Bueno-de-Mesquita, BH, Krogh, V, Tjønneland, A , Lauritzen, DF, Gurrea, AB, Quiros, JR, Stattin, P, Trichopoulou, A, Martimianaki, G, Karakatsani, A, Thysell, E, Johansson, I, Ricceri, F, Tumino, R, Larranaga, N, Khaw, KT, Riboli, E, Tzoulaki, I & Tsilidis, KK 2020, 'A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study', European Journal of Nutrition. https://doi.org/10.1007/s00394-019-02132-z

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title = "A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study",

abstract = "Purpose: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. Methods: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR ' 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS). Results: A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS. Conclusions: Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature.",

keywords = "Diet, Nutrition, Epidemiology, Cohort study, Prostate cancer",

author = "Nikos Papadimitriou and David Muller and {van den Brandt}, {Piet A.} and Milan Geybels and Patel, {Chirag J.} and Gunter, {Marc J.} and Lopez, {David S.} and Key, {Timothy J.} and Aurora Perez-Cornago and Pietro Ferrari and Paolo Vineis and Elisabete Weiderpass and Heiner Boeing and Antonio Agudo and Maria-Jose Sanchez and Kim Overvad and Tilman Kuehn and Fortner, {Renee T.} and Domenico Palli and Isabel Drake and Anders Bjartell and Carmen Santiuste and Bueno-de-Mesquita, {Bas H.} and Vittorio Krogh and Anne Tj{\o}nneland and Lauritzen, {Dorthe Furstrand} and Gurrea, {Aurelio Barricarte} and Quiros, {Jose Ramon} and Par Stattin and Antonia Trichopoulou and Georgia Martimianaki and Anna Karakatsani and Elin Thysell and Ingegerd Johansson and Fulvio Ricceri and Rosario Tumino and Nerea Larranaga and Khaw, {Kay Tee} and Elio Riboli and Ioanna Tzoulaki and Tsilidis, {Konstantinos K.}",

year = "2020",

month = oct,

day = "1",

doi = "10.1007/s00394-019-02132-z",

language = "English",

journal = "European Journal of Nutrition",

issn = "1436-6207",

publisher = "Springer Medizin",

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TY - JOUR

T1 - A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study

AU - Papadimitriou, Nikos

AU - Muller, David

AU - van den Brandt, Piet A.

AU - Geybels, Milan

AU - Patel, Chirag J.

AU - Gunter, Marc J.

AU - Lopez, David S.

AU - Key, Timothy J.

AU - Perez-Cornago, Aurora

AU - Ferrari, Pietro

AU - Vineis, Paolo

AU - Weiderpass, Elisabete

AU - Boeing, Heiner

AU - Agudo, Antonio

AU - Sanchez, Maria-Jose

AU - Overvad, Kim

AU - Kuehn, Tilman

AU - Fortner, Renee T.

AU - Palli, Domenico

AU - Drake, Isabel

AU - Bjartell, Anders

AU - Santiuste, Carmen

AU - Bueno-de-Mesquita, Bas H.

AU - Krogh, Vittorio

AU - Tjønneland, Anne

AU - Lauritzen, Dorthe Furstrand

AU - Gurrea, Aurelio Barricarte

AU - Quiros, Jose Ramon

AU - Stattin, Par

AU - Trichopoulou, Antonia

AU - Martimianaki, Georgia

AU - Karakatsani, Anna

AU - Thysell, Elin

AU - Johansson, Ingegerd

AU - Ricceri, Fulvio

AU - Tumino, Rosario

AU - Larranaga, Nerea

AU - Khaw, Kay Tee

AU - Riboli, Elio

AU - Tzoulaki, Ioanna

AU - Tsilidis, Konstantinos K.

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Purpose: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. Methods: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR ' 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS). Results: A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS. Conclusions: Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature.

AB - Purpose: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. Methods: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR ' 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS). Results: A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS. Conclusions: Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature.

KW - Diet

KW - Nutrition

KW - Epidemiology

KW - Cohort study

KW - Prostate cancer

U2 - 10.1007/s00394-019-02132-z

DO - 10.1007/s00394-019-02132-z

M3 - Journal article

C2 - 31705265

SN - 1436-6207

JO - European Journal of Nutrition

JF - European Journal of Nutrition

ER -

A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study

Abstract

Keywords

UN SDGs

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