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A novel pH-dependent gradient-release delivery system for nitrendipine: I. Manufacturing, evaluation in vitro and bioavailability in healthy dogs
Mingshi Yang
, Fude Cui, Bengang You, Jian You, Liang Wang, Liqiang Zhang, Yoshiaki Kawashima
35
Citations (Scopus)
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Dive into the research topics of 'A novel pH-dependent gradient-release delivery system for nitrendipine: I. Manufacturing, evaluation in vitro and bioavailability in healthy dogs'. Together they form a unique fingerprint.
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Medicine & Life Sciences
Nitrendipine
93%
Proton-Motive Force
88%
Microspheres
68%
Biological Availability
60%
Dogs
48%
In Vitro Techniques
29%
Drug Liberation
26%
hydroxypropyl methylcellulose phthalate
25%
Eudragit-E
24%
hydroxypropylmethylcellulose acetate succinate
24%
Temperature
19%
Water
17%
Acrylic Resins
17%
1,4-dihydropyridine
16%
X-Ray Diffraction
15%
Humidity
15%
Emulsions
14%
Particle Size
13%
Duodenum
13%
Small Intestine
12%
Polymers
11%
Pharmaceutical Preparations
11%
Acids
10%
Stomach
9%
Calcium
9%
Chemical Compounds
Nitrendipine
100%
Bioavailability
65%
Microsphere
57%
Drug
28%
Hydroxypropylmethylcellulose Phthalate
26%
Water Soluble
20%
Dissolution
19%
Tmax
18%
Calcium Antagonist
18%
Acrylic Resin
17%
Dihydropyridine
16%
Succinate
13%
Humidity
11%
pH Value
11%
Acetate
9%
Amorphous Material
9%
Shape
8%
Diffusion
8%
X-Ray Diffraction
6%
Solvent
6%
Acid
4%