A new automated method for analysis of gated-SPECT images based on a three-dimensional heart shaped model

Milan Lomsky; Jens Richter; Lena Johansson; Henrik El-Ali; Karl Aström; Michael Ljungberg; Lars Edenbrandt; Henrik H. El Ali

doi:10.1111/j.1475-097X.2005.00619.x

A new automated method for analysis of gated-SPECT images based on a three-dimensional heart shaped model

Milan Lomsky, Jens Richter, Lena Johansson, Henrik El-Ali, Karl Aström, Michael Ljungberg, Lars Edenbrandt, Henrik H. El Ali

Endocrinology and Metabolism

25 Citations (Scopus)

Abstract

A new automated method for quantification of left ventricular function from gated-single photon emission computed tomography (SPECT) images has been developed. The method for quantification of cardiac function (CAFU) is based on a heart shaped model and the active shape algorithm. The model contains statistical information of the variability of left ventricular shape. CAFU was adjusted based on the results from the analysis of five simulated gated-SPECT studies with well defined volumes of the left ventricle. The digital phantom NURBS-based Cardiac-Torso (NCAT) and the Monte-Carlo method SIMIND were used to simulate the studies. Finally CAFU was validated on ten rest studies from patients referred for routine stress/rest myocardial perfusion scintigraphy and compared with Cedar-Sinai quantitative gated-SPECT (QGS), a commercially available program for quantification of gated-SPECT images. The maximal differences between the CAFU estimations and the true left ventricular volumes of the digital phantoms were 11 ml for the end-diastolic volume (EDV), 3 ml for the end-systolic volume (ESV) and 3% for the ejection fraction (EF). The largest differences were seen in the smallest heart. In the patient group the EDV calculated using QGS and CAFU showed good agreement for large hearts and higher CAFU values compared with QGS for the smaller hearts. In the larger hearts, ESV was much larger for QGS than for CAFU both in the phantom and patient studies. In the smallest hearts there was good agreement between QGS and CAFU. The findings of this study indicate that our new automated method for quantification of gated-SPECT images can accurately measure left ventricular volumes and EF.

Original language	English
Journal	Clinical Physiology and Functional Imaging
Volume	25
Issue number	4
Pages (from-to)	234-40
Number of pages	7
ISSN	1475-0961
DOIs	https://doi.org/10.1111/j.1475-097X.2005.00619.x
Publication status	Published - Jul 2005

Keywords

Artificial Intelligence
Gated Blood-Pool Imaging
Heart Ventricles
Humans
Image Interpretation, Computer-Assisted
Imaging, Three-Dimensional
Models, Anatomic
Models, Cardiovascular
Phantoms, Imaging
Reproducibility of Results
Sensitivity and Specificity
Stroke Volume
Tomography, Emission-Computed, Single-Photon
Ventricular Function
Ventricular Function, Left

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10.1111/j.1475-097X.2005.00619.x

Cite this

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title = "A new automated method for analysis of gated-SPECT images based on a three-dimensional heart shaped model",

abstract = "A new automated method for quantification of left ventricular function from gated-single photon emission computed tomography (SPECT) images has been developed. The method for quantification of cardiac function (CAFU) is based on a heart shaped model and the active shape algorithm. The model contains statistical information of the variability of left ventricular shape. CAFU was adjusted based on the results from the analysis of five simulated gated-SPECT studies with well defined volumes of the left ventricle. The digital phantom NURBS-based Cardiac-Torso (NCAT) and the Monte-Carlo method SIMIND were used to simulate the studies. Finally CAFU was validated on ten rest studies from patients referred for routine stress/rest myocardial perfusion scintigraphy and compared with Cedar-Sinai quantitative gated-SPECT (QGS), a commercially available program for quantification of gated-SPECT images. The maximal differences between the CAFU estimations and the true left ventricular volumes of the digital phantoms were 11 ml for the end-diastolic volume (EDV), 3 ml for the end-systolic volume (ESV) and 3% for the ejection fraction (EF). The largest differences were seen in the smallest heart. In the patient group the EDV calculated using QGS and CAFU showed good agreement for large hearts and higher CAFU values compared with QGS for the smaller hearts. In the larger hearts, ESV was much larger for QGS than for CAFU both in the phantom and patient studies. In the smallest hearts there was good agreement between QGS and CAFU. The findings of this study indicate that our new automated method for quantification of gated-SPECT images can accurately measure left ventricular volumes and EF.",

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author = "Milan Lomsky and Jens Richter and Lena Johansson and Henrik El-Ali and Karl Astr{\"o}m and Michael Ljungberg and Lars Edenbrandt and {El Ali}, {Henrik H.}",

year = "2005",

month = jul,

doi = "10.1111/j.1475-097X.2005.00619.x",

language = "English",

volume = "25",

pages = "234--40",

journal = "Clinical Physiology and Functional Imaging",

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TY - JOUR

T1 - A new automated method for analysis of gated-SPECT images based on a three-dimensional heart shaped model

AU - Lomsky, Milan

AU - Richter, Jens

AU - Johansson, Lena

AU - El-Ali, Henrik

AU - Aström, Karl

AU - Ljungberg, Michael

AU - Edenbrandt, Lars

AU - El Ali, Henrik H.

PY - 2005/7

Y1 - 2005/7

N2 - A new automated method for quantification of left ventricular function from gated-single photon emission computed tomography (SPECT) images has been developed. The method for quantification of cardiac function (CAFU) is based on a heart shaped model and the active shape algorithm. The model contains statistical information of the variability of left ventricular shape. CAFU was adjusted based on the results from the analysis of five simulated gated-SPECT studies with well defined volumes of the left ventricle. The digital phantom NURBS-based Cardiac-Torso (NCAT) and the Monte-Carlo method SIMIND were used to simulate the studies. Finally CAFU was validated on ten rest studies from patients referred for routine stress/rest myocardial perfusion scintigraphy and compared with Cedar-Sinai quantitative gated-SPECT (QGS), a commercially available program for quantification of gated-SPECT images. The maximal differences between the CAFU estimations and the true left ventricular volumes of the digital phantoms were 11 ml for the end-diastolic volume (EDV), 3 ml for the end-systolic volume (ESV) and 3% for the ejection fraction (EF). The largest differences were seen in the smallest heart. In the patient group the EDV calculated using QGS and CAFU showed good agreement for large hearts and higher CAFU values compared with QGS for the smaller hearts. In the larger hearts, ESV was much larger for QGS than for CAFU both in the phantom and patient studies. In the smallest hearts there was good agreement between QGS and CAFU. The findings of this study indicate that our new automated method for quantification of gated-SPECT images can accurately measure left ventricular volumes and EF.

AB - A new automated method for quantification of left ventricular function from gated-single photon emission computed tomography (SPECT) images has been developed. The method for quantification of cardiac function (CAFU) is based on a heart shaped model and the active shape algorithm. The model contains statistical information of the variability of left ventricular shape. CAFU was adjusted based on the results from the analysis of five simulated gated-SPECT studies with well defined volumes of the left ventricle. The digital phantom NURBS-based Cardiac-Torso (NCAT) and the Monte-Carlo method SIMIND were used to simulate the studies. Finally CAFU was validated on ten rest studies from patients referred for routine stress/rest myocardial perfusion scintigraphy and compared with Cedar-Sinai quantitative gated-SPECT (QGS), a commercially available program for quantification of gated-SPECT images. The maximal differences between the CAFU estimations and the true left ventricular volumes of the digital phantoms were 11 ml for the end-diastolic volume (EDV), 3 ml for the end-systolic volume (ESV) and 3% for the ejection fraction (EF). The largest differences were seen in the smallest heart. In the patient group the EDV calculated using QGS and CAFU showed good agreement for large hearts and higher CAFU values compared with QGS for the smaller hearts. In the larger hearts, ESV was much larger for QGS than for CAFU both in the phantom and patient studies. In the smallest hearts there was good agreement between QGS and CAFU. The findings of this study indicate that our new automated method for quantification of gated-SPECT images can accurately measure left ventricular volumes and EF.

KW - Artificial Intelligence

KW - Gated Blood-Pool Imaging

KW - Heart Ventricles

KW - Humans

KW - Image Interpretation, Computer-Assisted

KW - Imaging, Three-Dimensional

KW - Models, Anatomic

KW - Models, Cardiovascular

KW - Phantoms, Imaging

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - Stroke Volume

KW - Tomography, Emission-Computed, Single-Photon

KW - Ventricular Function

KW - Ventricular Function, Left

U2 - 10.1111/j.1475-097X.2005.00619.x

DO - 10.1111/j.1475-097X.2005.00619.x

M3 - Journal article

C2 - 15972026

SN - 1475-0961

VL - 25

SP - 234

EP - 240

JO - Clinical Physiology and Functional Imaging

JF - Clinical Physiology and Functional Imaging

IS - 4

ER -

A new automated method for analysis of gated-SPECT images based on a three-dimensional heart shaped model

Abstract

Keywords

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