A neural cell adhesion molecule-derived fibroblast growth factor receptor agonist, the FGL-peptide, promotes early postnatal sensorimotor development and enhances social memory retention

TY - JOUR

T1 - A neural cell adhesion molecule-derived fibroblast growth factor receptor agonist, the FGL-peptide, promotes early postnatal sensorimotor development and enhances social memory retention

AU - Secher, Thomas

AU - Novitskaia, V

AU - Berezin, Vladimir

AU - Bock, E

AU - Glenthøj, B

AU - Klementiev, B

N1 - Keywords: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Blotting, Western; Body Weight; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Hindlimb Suspension; Locomotion; Memory; Neural Cell Adhesion Molecules; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Social Behavior; Time Factors

PY - 2006

Y1 - 2006

N2 - The neural cell adhesion molecule (NCAM) belongs to the immunoglobulin (Ig) superfamily and is composed extracellularly of five Ig-like and two fibronectin type III (F3) modules. It plays a pivotal role in neuronal development and synaptic plasticity. NCAM signals via a direct interaction with the fibroblast growth factor receptor (FGFR). A 15-amino-acid long peptide, the FG loop (FGL) peptide, that is derived from the second F3 module of NCAM has been found to activate FGFR1. We here report that the FGL peptide, when administered intranasally to newborn rats, accelerated early postnatal development of coordination skills. In adult animals s.c. administration of FGL resulted in a prolonged retention of social memory. We found that FGL rapidly penetrated into the blood and cerebrospinal fluid after both intranasal and s.c. administration and remained detectable in the fluids for up to 5 hours.

AB - The neural cell adhesion molecule (NCAM) belongs to the immunoglobulin (Ig) superfamily and is composed extracellularly of five Ig-like and two fibronectin type III (F3) modules. It plays a pivotal role in neuronal development and synaptic plasticity. NCAM signals via a direct interaction with the fibroblast growth factor receptor (FGFR). A 15-amino-acid long peptide, the FG loop (FGL) peptide, that is derived from the second F3 module of NCAM has been found to activate FGFR1. We here report that the FGL peptide, when administered intranasally to newborn rats, accelerated early postnatal development of coordination skills. In adult animals s.c. administration of FGL resulted in a prolonged retention of social memory. We found that FGL rapidly penetrated into the blood and cerebrospinal fluid after both intranasal and s.c. administration and remained detectable in the fluids for up to 5 hours.

U2 - 10.1016/j.neuroscience.2006.04.059

DO - 10.1016/j.neuroscience.2006.04.059

M3 - Journal article

C2 - 16784819

SN - 0306-4522

VL - 141

SP - 1289

EP - 1299

JO - Neuroscience

JF - Neuroscience

IS - 3

ER -