A nationwide study of serous “borderline” ovarian tumors in Denmark 1978–2002: Centralized pathology review and overall survival compared with the general population

Charlotte Gerd Hannibal; Russell Vang; Jette Junge; Kirsten Frederiksen; Anette Kjaerbye-Thygesen; Klaus Kaae Andersen; Ann Tabor; Robert J Kurman; Susanne K Kjaer

doi:10.1016/j.ygyno.2014.06.002

A nationwide study of serous “borderline” ovarian tumors in Denmark 1978–2002: Centralized pathology review and overall survival compared with the general population

Charlotte Gerd Hannibal, Russell Vang, Jette Junge, Kirsten Frederiksen, Anette Kjaerbye-Thygesen, Klaus Kaae Andersen, Ann Tabor, Robert J Kurman, Susanne K Kjaer

Department of Clinical Medicine

40 Citations (Scopus)

Abstract

Objective To describe the study population and estimate overall survival of women with a serous "borderline" ovarian tumor (SBT) in Denmark over 25 years relative to the general population. Methods The Danish Pathology Data Bank and the Danish Cancer Registry were used to identify 1487 women diagnosed with SBTs from 1978 to 2002. The histologic slides were collected from Danish pathology departments and reviewed by expert pathologists and classified as SBT/atypical proliferative serous tumor (APST) or noninvasive low-grade serous carcinoma (LGSC). Associated implants were classified as noninvasive or invasive. Medical records were collected from hospital departments and reviewed. Data were analyzed using Kaplan-Meier and relative survival was estimated with follow-up through September 2, 2013. Results A cohort of 1042 women with a confirmed SBT diagnosis was identified. Women with stage I had an overall survival similar to the overall survival expected from the general population (p = 0.3), whereas women with advanced stage disease had a poorer one (p < 0.0001). This was evident both in women with noninvasive (p < 0.0001) and invasive implants (p < 0.0001). Only among women with advanced stage, overall survival of women with SBT/APST (p < 0.0001) and noninvasive LGSC (p < 0.0001) was poorer than expected from the general population. Conclusions To date this is the largest nationwide cohort of SBTs where all tumors have been verified by expert pathologists. Only in women with advanced stage SBT, overall survival is poorer than in the general population which applies both to women with noninvasive and invasive implants as well as to women with SBT/APST and noninvasive LGSC.

Original language	English
Journal	Gynecologic Oncology
Volume	134
Issue number	2
Pages (from-to)	267–273
Number of pages	7
ISSN	0090-8258
DOIs	https://doi.org/10.1016/j.ygyno.2014.06.002
Publication status	Published - Aug 2014

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Denmark
Female
Humans
Middle Aged
Ovarian Neoplasms
Survival Rate
Time Factors
Young Adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ygyno.2014.06.002

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Hannibal, C. G., Vang, R., Junge, J., Frederiksen, K., Kjaerbye-Thygesen, A., Andersen, K. K., Tabor, A., Kurman, R. J., & Kjaer, S. K. (2014). A nationwide study of serous “borderline” ovarian tumors in Denmark 1978–2002: Centralized pathology review and overall survival compared with the general population. Gynecologic Oncology, 134(2), 267–273. https://doi.org/10.1016/j.ygyno.2014.06.002

Hannibal, CG, Vang, R, Junge, J, Frederiksen, K, Kjaerbye-Thygesen, A, Andersen, KK, Tabor, A, Kurman, RJ & Kjaer, SK 2014, 'A nationwide study of serous “borderline” ovarian tumors in Denmark 1978–2002: Centralized pathology review and overall survival compared with the general population', Gynecologic Oncology, vol. 134, no. 2, pp. 267–273. https://doi.org/10.1016/j.ygyno.2014.06.002

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title = "A nationwide study of serous “borderline” ovarian tumors in Denmark 1978–2002: Centralized pathology review and overall survival compared with the general population",

abstract = "Objective To describe the study population and estimate overall survival of women with a serous {"}borderline{"} ovarian tumor (SBT) in Denmark over 25 years relative to the general population. Methods The Danish Pathology Data Bank and the Danish Cancer Registry were used to identify 1487 women diagnosed with SBTs from 1978 to 2002. The histologic slides were collected from Danish pathology departments and reviewed by expert pathologists and classified as SBT/atypical proliferative serous tumor (APST) or noninvasive low-grade serous carcinoma (LGSC). Associated implants were classified as noninvasive or invasive. Medical records were collected from hospital departments and reviewed. Data were analyzed using Kaplan-Meier and relative survival was estimated with follow-up through September 2, 2013. Results A cohort of 1042 women with a confirmed SBT diagnosis was identified. Women with stage I had an overall survival similar to the overall survival expected from the general population (p = 0.3), whereas women with advanced stage disease had a poorer one (p < 0.0001). This was evident both in women with noninvasive (p < 0.0001) and invasive implants (p < 0.0001). Only among women with advanced stage, overall survival of women with SBT/APST (p < 0.0001) and noninvasive LGSC (p < 0.0001) was poorer than expected from the general population. Conclusions To date this is the largest nationwide cohort of SBTs where all tumors have been verified by expert pathologists. Only in women with advanced stage SBT, overall survival is poorer than in the general population which applies both to women with noninvasive and invasive implants as well as to women with SBT/APST and noninvasive LGSC.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Denmark, Female, Humans, Middle Aged, Ovarian Neoplasms, Survival Rate, Time Factors, Young Adult",

author = "Hannibal, {Charlotte Gerd} and Russell Vang and Jette Junge and Kirsten Frederiksen and Anette Kjaerbye-Thygesen and Andersen, {Klaus Kaae} and Ann Tabor and Kurman, {Robert J} and Kjaer, {Susanne K}",

note = "Copyright {\textcopyright} 2014. Published by Elsevier Inc.",

year = "2014",

month = aug,

doi = "10.1016/j.ygyno.2014.06.002",

language = "English",

volume = "134",

pages = "267–273",

journal = "Gynecologic Oncology",

issn = "0090-8258",

publisher = "Academic Press",

number = "2",

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TY - JOUR

T1 - A nationwide study of serous “borderline” ovarian tumors in Denmark 1978–2002

T2 - Centralized pathology review and overall survival compared with the general population

AU - Hannibal, Charlotte Gerd

AU - Vang, Russell

AU - Junge, Jette

AU - Frederiksen, Kirsten

AU - Kjaerbye-Thygesen, Anette

AU - Andersen, Klaus Kaae

AU - Tabor, Ann

AU - Kurman, Robert J

AU - Kjaer, Susanne K

PY - 2014/8

Y1 - 2014/8

N2 - Objective To describe the study population and estimate overall survival of women with a serous "borderline" ovarian tumor (SBT) in Denmark over 25 years relative to the general population. Methods The Danish Pathology Data Bank and the Danish Cancer Registry were used to identify 1487 women diagnosed with SBTs from 1978 to 2002. The histologic slides were collected from Danish pathology departments and reviewed by expert pathologists and classified as SBT/atypical proliferative serous tumor (APST) or noninvasive low-grade serous carcinoma (LGSC). Associated implants were classified as noninvasive or invasive. Medical records were collected from hospital departments and reviewed. Data were analyzed using Kaplan-Meier and relative survival was estimated with follow-up through September 2, 2013. Results A cohort of 1042 women with a confirmed SBT diagnosis was identified. Women with stage I had an overall survival similar to the overall survival expected from the general population (p = 0.3), whereas women with advanced stage disease had a poorer one (p < 0.0001). This was evident both in women with noninvasive (p < 0.0001) and invasive implants (p < 0.0001). Only among women with advanced stage, overall survival of women with SBT/APST (p < 0.0001) and noninvasive LGSC (p < 0.0001) was poorer than expected from the general population. Conclusions To date this is the largest nationwide cohort of SBTs where all tumors have been verified by expert pathologists. Only in women with advanced stage SBT, overall survival is poorer than in the general population which applies both to women with noninvasive and invasive implants as well as to women with SBT/APST and noninvasive LGSC.

AB - Objective To describe the study population and estimate overall survival of women with a serous "borderline" ovarian tumor (SBT) in Denmark over 25 years relative to the general population. Methods The Danish Pathology Data Bank and the Danish Cancer Registry were used to identify 1487 women diagnosed with SBTs from 1978 to 2002. The histologic slides were collected from Danish pathology departments and reviewed by expert pathologists and classified as SBT/atypical proliferative serous tumor (APST) or noninvasive low-grade serous carcinoma (LGSC). Associated implants were classified as noninvasive or invasive. Medical records were collected from hospital departments and reviewed. Data were analyzed using Kaplan-Meier and relative survival was estimated with follow-up through September 2, 2013. Results A cohort of 1042 women with a confirmed SBT diagnosis was identified. Women with stage I had an overall survival similar to the overall survival expected from the general population (p = 0.3), whereas women with advanced stage disease had a poorer one (p < 0.0001). This was evident both in women with noninvasive (p < 0.0001) and invasive implants (p < 0.0001). Only among women with advanced stage, overall survival of women with SBT/APST (p < 0.0001) and noninvasive LGSC (p < 0.0001) was poorer than expected from the general population. Conclusions To date this is the largest nationwide cohort of SBTs where all tumors have been verified by expert pathologists. Only in women with advanced stage SBT, overall survival is poorer than in the general population which applies both to women with noninvasive and invasive implants as well as to women with SBT/APST and noninvasive LGSC.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Denmark

KW - Female

KW - Humans

KW - Middle Aged

KW - Ovarian Neoplasms

KW - Survival Rate

KW - Time Factors

KW - Young Adult

U2 - 10.1016/j.ygyno.2014.06.002

DO - 10.1016/j.ygyno.2014.06.002

M3 - Review

C2 - 24924123

SN - 0090-8258

VL - 134

SP - 267

EP - 273

JO - Gynecologic Oncology

JF - Gynecologic Oncology

IS - 2

ER -

A nationwide study of serous “borderline” ovarian tumors in Denmark 1978–2002: Centralized pathology review and overall survival compared with the general population

Abstract

Keywords

UN SDGs

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