A marginal structural model for recurrent events in the presence of time-dependent confounding: non-specific effects of vaccines on child hospitalisations

Aksel K. G. Jensen; Henrik Ravn; Signe Sørup; Per Andersen

doi:10.1002/sim.7060

A marginal structural model for recurrent events in the presence of time-dependent confounding: non-specific effects of vaccines on child hospitalisations

Aksel K. G. Jensen, Henrik Ravn, Signe Sørup, Per Andersen

Section of Biostatistics

2 Citations (Scopus)

Abstract

Using a Danish register-based study on childhood vaccination and hospitalisation as motivation, a marginal structural model for recurrent events is studied. The model addresses a number of challenges which may be seen more generally in large register-based cohort studies. One is to adjust for a time-dependent confounder when studying the effect of a time-varying exposure on a recurrent event based on an analysis in continuous time. Another is to report results via a measure which is easy to interpret and communicate even though quite elaborate treatment regimes are considered. Lastly, the implementation of continuously updated weights implies a substantial computationally demanding workload.

Original language	English
Journal	Statistics in Medicine
Volume	35
Issue number	27
Pages (from-to)	5051-5069
Number of pages	19
ISSN	0277-6715
DOIs	https://doi.org/10.1002/sim.7060
Publication status	Published - 30 Nov 2016

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A marginal structural model for recurrent events in the presence of time-dependent confounding: non-specific effects of vaccines on child hospitalisations. / Jensen, Aksel K. G.; Ravn, Henrik; Sørup, Signe et al.
In: Statistics in Medicine, Vol. 35, No. 27, 30.11.2016, p. 5051-5069.

Research output: Contribution to journal › Journal article › Research › peer-review

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A marginal structural model for recurrent events in the presence of time-dependent confounding: non-specific effects of vaccines on child hospitalisations

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