A late IL-33 response after exposure to Schistosoma haematobium antigen is associated with an up-regulation of IL-13 in human eosinophils

S. Wilson; F. M. Jones; H. K. M. Fofana; A. Landouré; G. Kimani; J. K. Mwatha; M. Sacko; Birgitte J Vennervald; D. W. Dunne

doi:10.1111/pim.12035

A late IL-33 response after exposure to Schistosoma haematobium antigen is associated with an up-regulation of IL-13 in human eosinophils

S. Wilson, F. M. Jones, H. K. M. Fofana, A. Landouré, G. Kimani, J. K. Mwatha, M. Sacko, Birgitte J Vennervald, D. W. Dunne

11 Citations (Scopus)

Abstract

IL-33, a proposed alarmin, stimulates innate immune cells and Th2 cells to produce IL-13 and is rapidly upregulated upon antigen exposure in murine helminth infection. The human IL-33 response to helminth antigen was analysed in Malians infected with Schistosoma haematobium by disrupting parasite integrity via chemotherapy. Plasma IL-33 was measured pretreatment, and 24 h and 9 weeks post-treatment. At 24 h post-treatment, IL-33 levels were low. Nine week post-treatment IL-33 levels were elevated and were associated with an increase in intracellular IL-13 in eosinophils. Up-regulation of intracellular IL-13 in eosinophils was also associated with eosinophil expression of ST2L, the IL-33 receptor. IL-33 may play an important downstream role in the human response to schistosome adult worm antigen exposure.

Original language	English
Journal	Parasite Immunology
Volume	35
Issue number	7-8
Pages (from-to)	224-228
Number of pages	5
ISSN	0141-9838
DOIs	https://doi.org/10.1111/pim.12035
Publication status	Published - 2013

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10.1111/pim.12035

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@article{7446407b69604f66a2fa2397d81afbe0,

title = "A late IL-33 response after exposure to Schistosoma haematobium antigen is associated with an up-regulation of IL-13 in human eosinophils",

abstract = "IL-33, a proposed alarmin, stimulates innate immune cells and Th2 cells to produce IL-13 and is rapidly upregulated upon antigen exposure in murine helminth infection. The human IL-33 response to helminth antigen was analysed in Malians infected with Schistosoma haematobium by disrupting parasite integrity via chemotherapy. Plasma IL-33 was measured pretreatment, and 24 h and 9 weeks post-treatment. At 24 h post-treatment, IL-33 levels were low. Nine week post-treatment IL-33 levels were elevated and were associated with an increase in intracellular IL-13 in eosinophils. Up-regulation of intracellular IL-13 in eosinophils was also associated with eosinophil expression of ST2L, the IL-33 receptor. IL-33 may play an important downstream role in the human response to schistosome adult worm antigen exposure.",

author = "S. Wilson and Jones, {F. M.} and Fofana, {H. K. M.} and A. Landour{\'e} and G. Kimani and Mwatha, {J. K.} and M. Sacko and Vennervald, {Birgitte J} and Dunne, {D. W.}",

note = "{\textcopyright} 2013 John Wiley & Sons Ltd.",

year = "2013",

doi = "10.1111/pim.12035",

language = "English",

volume = "35",

pages = "224--228",

journal = "Parasite Immunology",

issn = "0141-9838",

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TY - JOUR

T1 - A late IL-33 response after exposure to Schistosoma haematobium antigen is associated with an up-regulation of IL-13 in human eosinophils

AU - Wilson, S.

AU - Jones, F. M.

AU - Fofana, H. K. M.

AU - Landouré, A.

AU - Kimani, G.

AU - Mwatha, J. K.

AU - Sacko, M.

AU - Vennervald, Birgitte J

AU - Dunne, D. W.

PY - 2013

Y1 - 2013

N2 - IL-33, a proposed alarmin, stimulates innate immune cells and Th2 cells to produce IL-13 and is rapidly upregulated upon antigen exposure in murine helminth infection. The human IL-33 response to helminth antigen was analysed in Malians infected with Schistosoma haematobium by disrupting parasite integrity via chemotherapy. Plasma IL-33 was measured pretreatment, and 24 h and 9 weeks post-treatment. At 24 h post-treatment, IL-33 levels were low. Nine week post-treatment IL-33 levels were elevated and were associated with an increase in intracellular IL-13 in eosinophils. Up-regulation of intracellular IL-13 in eosinophils was also associated with eosinophil expression of ST2L, the IL-33 receptor. IL-33 may play an important downstream role in the human response to schistosome adult worm antigen exposure.

AB - IL-33, a proposed alarmin, stimulates innate immune cells and Th2 cells to produce IL-13 and is rapidly upregulated upon antigen exposure in murine helminth infection. The human IL-33 response to helminth antigen was analysed in Malians infected with Schistosoma haematobium by disrupting parasite integrity via chemotherapy. Plasma IL-33 was measured pretreatment, and 24 h and 9 weeks post-treatment. At 24 h post-treatment, IL-33 levels were low. Nine week post-treatment IL-33 levels were elevated and were associated with an increase in intracellular IL-13 in eosinophils. Up-regulation of intracellular IL-13 in eosinophils was also associated with eosinophil expression of ST2L, the IL-33 receptor. IL-33 may play an important downstream role in the human response to schistosome adult worm antigen exposure.

U2 - 10.1111/pim.12035

DO - 10.1111/pim.12035

M3 - Journal article

C2 - 23521712

SN - 0141-9838

VL - 35

SP - 224

EP - 228

JO - Parasite Immunology

JF - Parasite Immunology

IS - 7-8

ER -

A late IL-33 response after exposure to Schistosoma haematobium antigen is associated with an up-regulation of IL-13 in human eosinophils

Abstract

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