A kinetic model explains why shorter and less affine enzyme-recruiting oligonucleotides can be more potent

Lykke Pedersen; Peter H. Hagedorn; Marie Wickstrom Lindholm; Morten Lindow

doi:10.1038/mtna.2013.72

A kinetic model explains why shorter and less affine enzyme-recruiting oligonucleotides can be more potent

Lykke Pedersen, Peter H. Hagedorn, Marie Wickstrom Lindholm, Morten Lindow

29 Citations (Scopus)

172 Downloads (Pure)

Original language	English
Article number	e149
Journal	Molecular Therapy - Nucleic Acids
Volume	3
Number of pages	8
ISSN	2162-2531
DOIs	https://doi.org/10.1038/mtna.2013.72
Publication status	Published - 18 Feb 2014

Keywords

kinetic model
oligonucleotide affinity
potency

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10.1038/mtna.2013.72

A Kinetic Model Explains Why Shorter and Less Affine Enzyme-recruiting Oligonucleotides Can Be More PotentFinal published version, 598 KB

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title = "A kinetic model explains why shorter and less affine enzyme-recruiting oligonucleotides can be more potent",

keywords = "kinetic model, oligonucleotide affinity, potency",

author = "Lykke Pedersen and Hagedorn, {Peter H.} and Lindholm, {Marie Wickstrom} and Morten Lindow",

year = "2014",

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T1 - A kinetic model explains why shorter and less affine enzyme-recruiting oligonucleotides can be more potent

AU - Pedersen, Lykke

AU - Hagedorn, Peter H.

AU - Lindholm, Marie Wickstrom

AU - Lindow, Morten

PY - 2014/2/18

Y1 - 2014/2/18

KW - kinetic model

KW - oligonucleotide affinity

KW - potency

U2 - 10.1038/mtna.2013.72

DO - 10.1038/mtna.2013.72

M3 - Journal article

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VL - 3

JO - Molecular Therapy Nucleic Acids

JF - Molecular Therapy Nucleic Acids

M1 - e149

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A kinetic model explains why shorter and less affine enzyme-recruiting oligonucleotides can be more potent

Keywords

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