A high-protein diet during hospitalization is associated with an accelerated decrease in soluble urokinase plasminogen activator receptor levels in acutely ill elderly medical patients with SIRS

Juliette Tavenier; Thomas Huneck Haupt; Aino L Andersen; Sussi F Buhl; Anne Langkilde; Jens Rikardt Andersen; Jens-Erik B Jensen; Mette M Pedersen; Janne Petersen; Ove Andersen

doi:10.1016/j.nutres.2017.04.006

A high-protein diet during hospitalization is associated with an accelerated decrease in soluble urokinase plasminogen activator receptor levels in acutely ill elderly medical patients with SIRS

Juliette Tavenier, Thomas Huneck Haupt, Aino L Andersen, Sussi F Buhl, Anne Langkilde, Jens Rikardt Andersen, Jens-Erik B Jensen, Mette M Pedersen, Janne Petersen, Ove Andersen

5 Citations (Scopus)

Abstract

Acute illness and hospitalization in elderly individuals are often accompanied by the systemic inflammatory response syndrome (SIRS) and malnutrition, both associated with wasting and mortality. Nutritional support and resistance training were shown to increase muscle anabolism and reduce inflammation in healthy elderly. We hypothesized that nutritional support and resistance training would accelerate the resolution of inflammation in hospitalized elderly patients with SIRS. Acutely admitted patients aged >65 years with SIRS were randomized to an intervention consisting of a high-protein diet (1.7 g/kg per day) during hospitalization, and daily protein supplement (18.8 g) and 3 weekly resistance training sessions for 12 weeks after discharge (Intervention, n=14), or to standard-care (Control, n=15). Plasma levels of the inflammatory biomarkers soluble urokinase plasminogen activator receptor (suPAR), interleukin-6, C-reactive protein (CRP), and albumin were measured at admission, discharge, and 4 and 13 weeks after discharge. The Intervention group had an earlier decrease in suPAR levels than the Control group: -15.4% vs. +14.5%, P=.007 during hospitalization, and -2.4% vs. -28.6%, P=.007 between discharge and 4 weeks. There were no significant effects of the intervention on the other biomarkers. All biomarkers improved significantly between admission and 13 weeks, although with different kinetics (suPAR: -22%, interleukin-6: -86%, CRP: -89%, albumin: +11%). Nutritional support during hospitalization was associated with an accelerated decrease in suPAR levels, whereas the combined nutrition and resistance training intervention after discharge did not appear to affect the inflammatory state. Our results indicate that improved nutritional care during hospitalization may accelerate recovery in acutely ill elderly medical patients.

Original language	English
Journal	Nutrition Research
Volume	41
Pages (from-to)	56-64
Number of pages	9
ISSN	0271-5317
DOIs	https://doi.org/10.1016/j.nutres.2017.04.006
Publication status	Published - May 2017

Keywords

Acutely ill elderly medical patients
Systemic Inflammatory Response Syndrome
Soluble urokinase plasminogen activator receptor
Inflammation
Nutritional support

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.nutres.2017.04.006

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Tavenier, J., Haupt, T. H., Andersen, A. L., Buhl, S. F., Langkilde, A., Andersen, J. R., Jensen, J-E. B., Pedersen, M. M., Petersen, J., & Andersen, O. (2017). A high-protein diet during hospitalization is associated with an accelerated decrease in soluble urokinase plasminogen activator receptor levels in acutely ill elderly medical patients with SIRS. Nutrition Research, 41, 56-64. https://doi.org/10.1016/j.nutres.2017.04.006

A high-protein diet during hospitalization is associated with an accelerated decrease in soluble urokinase plasminogen activator receptor levels in acutely ill elderly medical patients with SIRS. / Tavenier, Juliette; Haupt, Thomas Huneck; Andersen, Aino L et al.

In: Nutrition Research, Vol. 41, 05.2017, p. 56-64.

Research output: Contribution to journal › Journal article › Research › peer-review

Tavenier, J, Haupt, TH, Andersen, AL, Buhl, SF, Langkilde, A, Andersen, JR, Jensen, J-EB, Pedersen, MM, Petersen, J & Andersen, O 2017, 'A high-protein diet during hospitalization is associated with an accelerated decrease in soluble urokinase plasminogen activator receptor levels in acutely ill elderly medical patients with SIRS', Nutrition Research, vol. 41, pp. 56-64. https://doi.org/10.1016/j.nutres.2017.04.006

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title = "A high-protein diet during hospitalization is associated with an accelerated decrease in soluble urokinase plasminogen activator receptor levels in acutely ill elderly medical patients with SIRS",

abstract = "Acute illness and hospitalization in elderly individuals are often accompanied by the systemic inflammatory response syndrome (SIRS) and malnutrition, both associated with wasting and mortality. Nutritional support and resistance training were shown to increase muscle anabolism and reduce inflammation in healthy elderly. We hypothesized that nutritional support and resistance training would accelerate the resolution of inflammation in hospitalized elderly patients with SIRS. Acutely admitted patients aged >65 years with SIRS were randomized to an intervention consisting of a high-protein diet (1.7 g/kg per day) during hospitalization, and daily protein supplement (18.8 g) and 3 weekly resistance training sessions for 12 weeks after discharge (Intervention, n=14), or to standard-care (Control, n=15). Plasma levels of the inflammatory biomarkers soluble urokinase plasminogen activator receptor (suPAR), interleukin-6, C-reactive protein (CRP), and albumin were measured at admission, discharge, and 4 and 13 weeks after discharge. The Intervention group had an earlier decrease in suPAR levels than the Control group: -15.4% vs. +14.5%, P=.007 during hospitalization, and -2.4% vs. -28.6%, P=.007 between discharge and 4 weeks. There were no significant effects of the intervention on the other biomarkers. All biomarkers improved significantly between admission and 13 weeks, although with different kinetics (suPAR: -22%, interleukin-6: -86%, CRP: -89%, albumin: +11%). Nutritional support during hospitalization was associated with an accelerated decrease in suPAR levels, whereas the combined nutrition and resistance training intervention after discharge did not appear to affect the inflammatory state. Our results indicate that improved nutritional care during hospitalization may accelerate recovery in acutely ill elderly medical patients.",

keywords = "Acutely ill elderly medical patients, Systemic Inflammatory Response Syndrome, Soluble urokinase plasminogen activator receptor, Inflammation, Nutritional support",

author = "Juliette Tavenier and Haupt, {Thomas Huneck} and Andersen, {Aino L} and Buhl, {Sussi F} and Anne Langkilde and Andersen, {Jens Rikardt} and Jensen, {Jens-Erik B} and Pedersen, {Mette M} and Janne Petersen and Ove Andersen",

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T1 - A high-protein diet during hospitalization is associated with an accelerated decrease in soluble urokinase plasminogen activator receptor levels in acutely ill elderly medical patients with SIRS

AU - Tavenier, Juliette

AU - Haupt, Thomas Huneck

AU - Andersen, Aino L

AU - Buhl, Sussi F

AU - Langkilde, Anne

AU - Andersen, Jens Rikardt

AU - Jensen, Jens-Erik B

AU - Pedersen, Mette M

AU - Petersen, Janne

AU - Andersen, Ove

N1 - CURIS 2017 NEXS 135

PY - 2017/5

Y1 - 2017/5

N2 - Acute illness and hospitalization in elderly individuals are often accompanied by the systemic inflammatory response syndrome (SIRS) and malnutrition, both associated with wasting and mortality. Nutritional support and resistance training were shown to increase muscle anabolism and reduce inflammation in healthy elderly. We hypothesized that nutritional support and resistance training would accelerate the resolution of inflammation in hospitalized elderly patients with SIRS. Acutely admitted patients aged >65 years with SIRS were randomized to an intervention consisting of a high-protein diet (1.7 g/kg per day) during hospitalization, and daily protein supplement (18.8 g) and 3 weekly resistance training sessions for 12 weeks after discharge (Intervention, n=14), or to standard-care (Control, n=15). Plasma levels of the inflammatory biomarkers soluble urokinase plasminogen activator receptor (suPAR), interleukin-6, C-reactive protein (CRP), and albumin were measured at admission, discharge, and 4 and 13 weeks after discharge. The Intervention group had an earlier decrease in suPAR levels than the Control group: -15.4% vs. +14.5%, P=.007 during hospitalization, and -2.4% vs. -28.6%, P=.007 between discharge and 4 weeks. There were no significant effects of the intervention on the other biomarkers. All biomarkers improved significantly between admission and 13 weeks, although with different kinetics (suPAR: -22%, interleukin-6: -86%, CRP: -89%, albumin: +11%). Nutritional support during hospitalization was associated with an accelerated decrease in suPAR levels, whereas the combined nutrition and resistance training intervention after discharge did not appear to affect the inflammatory state. Our results indicate that improved nutritional care during hospitalization may accelerate recovery in acutely ill elderly medical patients.

AB - Acute illness and hospitalization in elderly individuals are often accompanied by the systemic inflammatory response syndrome (SIRS) and malnutrition, both associated with wasting and mortality. Nutritional support and resistance training were shown to increase muscle anabolism and reduce inflammation in healthy elderly. We hypothesized that nutritional support and resistance training would accelerate the resolution of inflammation in hospitalized elderly patients with SIRS. Acutely admitted patients aged >65 years with SIRS were randomized to an intervention consisting of a high-protein diet (1.7 g/kg per day) during hospitalization, and daily protein supplement (18.8 g) and 3 weekly resistance training sessions for 12 weeks after discharge (Intervention, n=14), or to standard-care (Control, n=15). Plasma levels of the inflammatory biomarkers soluble urokinase plasminogen activator receptor (suPAR), interleukin-6, C-reactive protein (CRP), and albumin were measured at admission, discharge, and 4 and 13 weeks after discharge. The Intervention group had an earlier decrease in suPAR levels than the Control group: -15.4% vs. +14.5%, P=.007 during hospitalization, and -2.4% vs. -28.6%, P=.007 between discharge and 4 weeks. There were no significant effects of the intervention on the other biomarkers. All biomarkers improved significantly between admission and 13 weeks, although with different kinetics (suPAR: -22%, interleukin-6: -86%, CRP: -89%, albumin: +11%). Nutritional support during hospitalization was associated with an accelerated decrease in suPAR levels, whereas the combined nutrition and resistance training intervention after discharge did not appear to affect the inflammatory state. Our results indicate that improved nutritional care during hospitalization may accelerate recovery in acutely ill elderly medical patients.

KW - Acutely ill elderly medical patients

KW - Systemic Inflammatory Response Syndrome

KW - Soluble urokinase plasminogen activator receptor

KW - Inflammation

KW - Nutritional support

U2 - 10.1016/j.nutres.2017.04.006

DO - 10.1016/j.nutres.2017.04.006

M3 - Journal article

C2 - 28477944

SN - 0271-5317

VL - 41

SP - 56

EP - 64

JO - Nutrition Research

JF - Nutrition Research

ER -

A high-protein diet during hospitalization is associated with an accelerated decrease in soluble urokinase plasminogen activator receptor levels in acutely ill elderly medical patients with SIRS

Abstract

Keywords

UN SDGs

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