Enciso-Mora, V., Broderick, P., Ma, Y., Jarrett, R. F., Hjalgrim, H., Hemminki, K., Van Den Berg, A., Olver, B., Lloyd, A., Dobbins, S. E., Lightfoot, T., van Leeuwen, F. E., Försti, A., Diepstra, A., Broeks, A., Vijayakrishnan, J., Shield, L., Lake, A., Montgomery, D., ... Houlston, R. S. (2010). A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). Nature Genetics, 42(12), 1126-1130. https://doi.org/10.1038/ng.696
Enciso-Mora, V, Broderick, P, Ma, Y, Jarrett, RF, Hjalgrim, H, Hemminki, K, Van Den Berg, A, Olver, B, Lloyd, A, Dobbins, SE, Lightfoot, T, van Leeuwen, FE, Försti, A, Diepstra, A, Broeks, A, Vijayakrishnan, J, Shield, L, Lake, A, Montgomery, D, Roman, E, Engert, A, Von Strandmann, EP, Reiners, KS, Nolte, IM, Smedby, KE, Adami, H-O, Russell, NS, Glimelius, B, Hamilton-Dutoit, S, De Bruin, M, Ryder, LP, Molin, DGM, Sorensen, KM, Chang, ET, Taylor, AMR, Cooke, R, Hofstra, R, Westers, H, Van Wezel, T, Van Eijk, R, Ashworth, A, Rostgaard, K, Melbye, M, Swerdlow, AJ & Houlston, RS 2010, 'A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)', Nature Genetics, vol. 42, no. 12, pp. 1126-1130. https://doi.org/10.1038/ng.696
@article{16d23cdaf0084df6b4c9385cf13bcb19,
title = "A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)",
abstract = "To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10 -8), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10-13) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10-8). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10 -50). These data provide new insight into the pathogenesis of cHL.",
author = "Victor Enciso-Mora and Peter Broderick and Yussanne Ma and Jarrett, {Ruth F} and Henrik Hjalgrim and Kari Hemminki and {Van Den Berg}, Anke and Bianca Olver and Amy Lloyd and Dobbins, {Sara E.} and Tracy Lightfoot and {van Leeuwen}, {Flora E} and Asta F{\"o}rsti and Arjan Diepstra and Annegien Broeks and Jayaram Vijayakrishnan and Lesley Shield and Annette Lake and Dorothy Montgomery and Eve Roman and Andreas Engert and {Von Strandmann}, {Elke Pogge} and Reiners, {Katrin S.} and Nolte, {Ilja M} and Smedby, {Karin E} and Hans-Olov Adami and Russell, {Nicola S} and Bengt Glimelius and Stephen Hamilton-Dutoit and {De Bruin}, Marieke and Ryder, {Lars P.} and Molin, {Daniel G. M.} and Sorensen, {Karina Meden} and Chang, {Ellen T.} and Taylor, {A. Malcolm R.} and Rosie Cooke and Robert Hofstra and Helga Westers and {Van Wezel}, Tom and {Van Eijk}, Ronald and Alan Ashworth and Klaus Rostgaard and Mads Melbye and Swerdlow, {Anthony J} and Houlston, {Richard S}",
year = "2010",
month = dec,
doi = "10.1038/ng.696",
language = "English",
volume = "42",
pages = "1126--1130",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "12",
}
TY - JOUR
T1 - A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)
AU - Enciso-Mora, Victor
AU - Broderick, Peter
AU - Ma, Yussanne
AU - Jarrett, Ruth F
AU - Hjalgrim, Henrik
AU - Hemminki, Kari
AU - Van Den Berg, Anke
AU - Olver, Bianca
AU - Lloyd, Amy
AU - Dobbins, Sara E.
AU - Lightfoot, Tracy
AU - van Leeuwen, Flora E
AU - Försti, Asta
AU - Diepstra, Arjan
AU - Broeks, Annegien
AU - Vijayakrishnan, Jayaram
AU - Shield, Lesley
AU - Lake, Annette
AU - Montgomery, Dorothy
AU - Roman, Eve
AU - Engert, Andreas
AU - Von Strandmann, Elke Pogge
AU - Reiners, Katrin S.
AU - Nolte, Ilja M
AU - Smedby, Karin E
AU - Adami, Hans-Olov
AU - Russell, Nicola S
AU - Glimelius, Bengt
AU - Hamilton-Dutoit, Stephen
AU - De Bruin, Marieke
AU - Ryder, Lars P.
AU - Molin, Daniel G. M.
AU - Sorensen, Karina Meden
AU - Chang, Ellen T.
AU - Taylor, A. Malcolm R.
AU - Cooke, Rosie
AU - Hofstra, Robert
AU - Westers, Helga
AU - Van Wezel, Tom
AU - Van Eijk, Ronald
AU - Ashworth, Alan
AU - Rostgaard, Klaus
AU - Melbye, Mads
AU - Swerdlow, Anthony J
AU - Houlston, Richard S
PY - 2010/12
Y1 - 2010/12
N2 - To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10 -8), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10-13) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10-8). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10 -50). These data provide new insight into the pathogenesis of cHL.
AB - To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10 -8), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10-13) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10-8). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10 -50). These data provide new insight into the pathogenesis of cHL.
UR - http://www.scopus.com/inward/record.url?scp=78649471895&partnerID=8YFLogxK
U2 - 10.1038/ng.696
DO - 10.1038/ng.696
M3 - Journal article
C2 - 21037568
AN - SCOPUS:78649471895
SN - 1061-4036
VL - 42
SP - 1126
EP - 1130
JO - Nature Genetics
JF - Nature Genetics
IS - 12
ER -
