A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2

William Garland; Itys Comet; Mengjun Wu; Aliaksandra Radzisheuskaya; Leonor Rib; Kristoffer Vitting-Seerup; Marta Lloret-Llinares; Albin Sandelin; Kristian Helin; Torben Heick Jensen

doi:10.1016/j.celrep.2019.10.011

A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2

William Garland, Itys Comet, Mengjun Wu, Aliaksandra Radzisheuskaya, Leonor Rib, Kristoffer Vitting-Seerup, Marta Lloret-Llinares, Albin Sandelin, Kristian Helin, Torben Heick Jensen

Computational and RNA Biology

11 Citations (Scopus)

4 Downloads (Pure)

Abstract

ZFC3H1 targets pA⁺ RNA for decay by the nuclear RNA exosome. Garland et al. report a disruptive relationship between excess RNA and PRC2 upon depletion of ZFC3H1 in mouse ESCs. In such conditions, RNA is bound by PRC2 components, which show reduced binding to chromatin and fellow PRC2 proteins.

Original language	English
Journal	Cell Reports
Volume	29
Issue number	7
Pages (from-to)	1800-1811
Number of pages	12
ISSN	2211-1247
DOIs	https://doi.org/10.1016/j.celrep.2019.10.011
Publication status	Published - 12 Nov 2019

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10.1016/j.celrep.2019.10.011Licence: CC BY-NC-ND

A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2Final published version, 5.01 MBLicence: CC BY-NC-ND

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title = "A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2",

abstract = "ZFC3H1 targets pA+ RNA for decay by the nuclear RNA exosome. Garland et al. report a disruptive relationship between excess RNA and PRC2 upon depletion of ZFC3H1 in mouse ESCs. In such conditions, RNA is bound by PRC2 components, which show reduced binding to chromatin and fellow PRC2 proteins.",

author = "William Garland and Itys Comet and Mengjun Wu and Aliaksandra Radzisheuskaya and Leonor Rib and Kristoffer Vitting-Seerup and Marta Lloret-Llinares and Albin Sandelin and Kristian Helin and Jensen, {Torben Heick}",

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T1 - A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2

AU - Garland, William

AU - Comet, Itys

AU - Wu, Mengjun

AU - Radzisheuskaya, Aliaksandra

AU - Rib, Leonor

AU - Vitting-Seerup, Kristoffer

AU - Lloret-Llinares, Marta

AU - Sandelin, Albin

AU - Helin, Kristian

AU - Jensen, Torben Heick

PY - 2019/11/12

Y1 - 2019/11/12

N2 - ZFC3H1 targets pA+ RNA for decay by the nuclear RNA exosome. Garland et al. report a disruptive relationship between excess RNA and PRC2 upon depletion of ZFC3H1 in mouse ESCs. In such conditions, RNA is bound by PRC2 components, which show reduced binding to chromatin and fellow PRC2 proteins.

AB - ZFC3H1 targets pA+ RNA for decay by the nuclear RNA exosome. Garland et al. report a disruptive relationship between excess RNA and PRC2 upon depletion of ZFC3H1 in mouse ESCs. In such conditions, RNA is bound by PRC2 components, which show reduced binding to chromatin and fellow PRC2 proteins.

U2 - 10.1016/j.celrep.2019.10.011

DO - 10.1016/j.celrep.2019.10.011

M3 - Journal article

C2 - 31722198

SN - 2639-1856

VL - 29

SP - 1800

EP - 1811

JO - Cell Reports

JF - Cell Reports

IS - 7

ER -

A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2

Abstract

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