A database study that identifies genes whose expression correlates, negatively or positively, with 5-year survival of cancer patients

TY - JOUR

T1 - A database study that identifies genes whose expression correlates, negatively or positively, with 5-year survival of cancer patients

AU - Stein, Wilfred D

AU - Litman, Thomas

AU - Fojo, Tito

AU - Bates, Susan E

PY - 2007/6

Y1 - 2007/6

N2 - A published microarray gene expression database containing data on 174 tumor samples from ten tissues was mined, enabling the identification of classes of genes whose expression correlates significantly with the intractability, or tractability, to therapy of tumors derived from such tissues. As a measure of tractability, the 5-year survival of patients presenting with distant (metastatic) tumors was used. Genes that encode proteins related to cell adhesion, and enzymes involved in metabolic oxidation or reduction, were upregulated in intractable cancers. Genes that encode proteins implicated in the control of DNA transcription were downregulated in the intractable cancers. We describe hypotheses with regard to cell functions that may help in designing new therapeutic modalities, aimed at improving survival of cancer patients.

AB - A published microarray gene expression database containing data on 174 tumor samples from ten tissues was mined, enabling the identification of classes of genes whose expression correlates significantly with the intractability, or tractability, to therapy of tumors derived from such tissues. As a measure of tractability, the 5-year survival of patients presenting with distant (metastatic) tumors was used. Genes that encode proteins related to cell adhesion, and enzymes involved in metabolic oxidation or reduction, were upregulated in intractable cancers. Genes that encode proteins implicated in the control of DNA transcription were downregulated in the intractable cancers. We describe hypotheses with regard to cell functions that may help in designing new therapeutic modalities, aimed at improving survival of cancer patients.

KW - Databases, Genetic

KW - Disease-Free Survival

KW - Female

KW - Gene Expression Regulation, Neoplastic

KW - Genes, Neoplasm

KW - Humans

KW - Male

KW - Models, Biological

KW - Neoplasm Metastasis

KW - Neoplasm Proteins

KW - Neoplasms

KW - Retrospective Studies

KW - Time Factors

U2 - 10.1016/j.bbagen.2006.12.013

DO - 10.1016/j.bbagen.2006.12.013

M3 - Journal article

C2 - 17398010

SN - 0304-4165

VL - 1770

SP - 857

EP - 871

JO - B B A - General Subjects

JF - B B A - General Subjects

IS - 6

ER -