A cross-sectional study on trans-fatty acids and risk markers of CHD among middle-aged men representing a broad range of BMI

Birgit Marie Nielsen; Marie M. Nielsen; Marianne Uhre Jakobsen; Carina J. Nielsen; Claus Holst; Thomas Meinert Larsen; Nathalie Tommerup Bendsen; Anette Bysted; Torben Leth; David M. Hougaard; Kristin Skogstrand; Arne Astrup; Thorkild I.A. Sørensen; Tine Jess

doi:10.1017/S0007114511001474

A cross-sectional study on trans-fatty acids and risk markers of CHD among middle-aged men representing a broad range of BMI

Birgit Marie Nielsen, Marie M. Nielsen, Marianne Uhre Jakobsen, Carina J. Nielsen, Claus Holst, Thomas Meinert Larsen, Nathalie Tommerup Bendsen, Anette Bysted, Torben Leth, David M. Hougaard, Kristin Skogstrand, Arne Astrup, Thorkild I.A. Sørensen, Tine Jess

8 Citations (Scopus)

Abstract

Intake of trans-fatty acids (TFA), especially industrially produced TFA (I-TFA), has been associated with the risk of CHD through influence on serum lipid levels. Other causal pathways remain less investigated. In the present cross-sectional study of middle-aged men representing a broad range of BMI, the association between intake of TFA, I-TFA and ruminant TFA (R-TFA) and obesity-associated risk markers of CHD was assessed. The study comprised 393 Danish men (median age 49 years) with a median BMI of 28·4 kg/m ². Intake of TFA was estimated based on 7 d dietary records, whereas outcomes of interest (waist circumference, sagittal abdominal diameter, percentage of truncal fat, C-reactive protein, IL-6, blood lipids, blood pressure, HbA1c and insulin sensitivity index) were obtained through clinical examination. The associations were assessed by linear regression analysis. The median intake of total TFA among the 393 men was 1·3 g/d, covering a daily I-TFA intake of 0·4 g (10-90th percentile 0·0-1·0) and R-TFA intake of 0·9 g (10-90th percentile 0·4-1·8). Intake of these amounts of TFA showed no significant associations with abdominal fatness, inflammatory markers, blood lipids, blood pressure and insulin homeostasis. Among middle-aged men with a generally low intake of TFA, neither I-TFA nor R-TFA was significantly related to obesity-associated risk markers of CHD. The decreased average intake of I-TFA in Denmark since 1995 is suggested to effectively prevent occurrence of the adverse metabolic changes and health consequences, which have formerly been observed in relation to, especially, I-TFA intake. ©

Original language	English
Journal	British Journal of Nutrition
Volume	106
Issue number	8
Pages (from-to)	1245-1252
Number of pages	8
ISSN	0007-1145
DOIs	https://doi.org/10.1017/S0007114511001474
Publication status	Published - 28 Oct 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1017/S0007114511001474

Cite this

Nielsen, B. M., Nielsen, M. M., Jakobsen, M. U., Nielsen, C. J., Holst, C., Larsen, T. M., Bendsen, N. T., Bysted, A., Leth, T., Hougaard, D. M., Skogstrand, K., Astrup, A., Sørensen, T. I. A., & Jess, T. (2011). A cross-sectional study on trans-fatty acids and risk markers of CHD among middle-aged men representing a broad range of BMI. British Journal of Nutrition, 106(8), 1245-1252. https://doi.org/10.1017/S0007114511001474

Nielsen, BM, Nielsen, MM, Jakobsen, MU, Nielsen, CJ, Holst, C, Larsen, TM, Bendsen, NT, Bysted, A, Leth, T, Hougaard, DM, Skogstrand, K, Astrup, A, Sørensen, TIA & Jess, T 2011, 'A cross-sectional study on trans-fatty acids and risk markers of CHD among middle-aged men representing a broad range of BMI', British Journal of Nutrition, vol. 106, no. 8, pp. 1245-1252. https://doi.org/10.1017/S0007114511001474

@article{17379ed950f6424ea6bb997d404f8786,

title = "A cross-sectional study on trans-fatty acids and risk markers of CHD among middle-aged men representing a broad range of BMI",

abstract = "Intake of trans-fatty acids (TFA), especially industrially produced TFA (I-TFA), has been associated with the risk of CHD through influence on serum lipid levels. Other causal pathways remain less investigated. In the present cross-sectional study of middle-aged men representing a broad range of BMI, the association between intake of TFA, I-TFA and ruminant TFA (R-TFA) and obesity-associated risk markers of CHD was assessed. The study comprised 393 Danish men (median age 49 years) with a median BMI of 28·4 kg/m 2. Intake of TFA was estimated based on 7 d dietary records, whereas outcomes of interest (waist circumference, sagittal abdominal diameter, percentage of truncal fat, C-reactive protein, IL-6, blood lipids, blood pressure, HbA1c and insulin sensitivity index) were obtained through clinical examination. The associations were assessed by linear regression analysis. The median intake of total TFA among the 393 men was 1·3 g/d, covering a daily I-TFA intake of 0·4 g (10-90th percentile 0·0-1·0) and R-TFA intake of 0·9 g (10-90th percentile 0·4-1·8). Intake of these amounts of TFA showed no significant associations with abdominal fatness, inflammatory markers, blood lipids, blood pressure and insulin homeostasis. Among middle-aged men with a generally low intake of TFA, neither I-TFA nor R-TFA was significantly related to obesity-associated risk markers of CHD. The decreased average intake of I-TFA in Denmark since 1995 is suggested to effectively prevent occurrence of the adverse metabolic changes and health consequences, which have formerly been observed in relation to, especially, I-TFA intake. {\textcopyright}",

author = "Nielsen, {Birgit Marie} and Nielsen, {Marie M.} and Jakobsen, {Marianne Uhre} and Nielsen, {Carina J.} and Claus Holst and Larsen, {Thomas Meinert} and Bendsen, {Nathalie Tommerup} and Anette Bysted and Torben Leth and Hougaard, {David M.} and Kristin Skogstrand and Arne Astrup and S{\o}rensen, {Thorkild I.A.} and Tine Jess",

year = "2011",

month = oct,

day = "28",

doi = "10.1017/S0007114511001474",

language = "English",

volume = "106",

pages = "1245--1252",

journal = "British Journal of Nutrition",

issn = "0007-1145",

publisher = "Cambridge University Press",

number = "8",

}

TY - JOUR

T1 - A cross-sectional study on trans-fatty acids and risk markers of CHD among middle-aged men representing a broad range of BMI

AU - Nielsen, Birgit Marie

AU - Nielsen, Marie M.

AU - Jakobsen, Marianne Uhre

AU - Nielsen, Carina J.

AU - Holst, Claus

AU - Larsen, Thomas Meinert

AU - Bendsen, Nathalie Tommerup

AU - Bysted, Anette

AU - Leth, Torben

AU - Hougaard, David M.

AU - Skogstrand, Kristin

AU - Astrup, Arne

AU - Sørensen, Thorkild I.A.

AU - Jess, Tine

PY - 2011/10/28

Y1 - 2011/10/28

N2 - Intake of trans-fatty acids (TFA), especially industrially produced TFA (I-TFA), has been associated with the risk of CHD through influence on serum lipid levels. Other causal pathways remain less investigated. In the present cross-sectional study of middle-aged men representing a broad range of BMI, the association between intake of TFA, I-TFA and ruminant TFA (R-TFA) and obesity-associated risk markers of CHD was assessed. The study comprised 393 Danish men (median age 49 years) with a median BMI of 28·4 kg/m 2. Intake of TFA was estimated based on 7 d dietary records, whereas outcomes of interest (waist circumference, sagittal abdominal diameter, percentage of truncal fat, C-reactive protein, IL-6, blood lipids, blood pressure, HbA1c and insulin sensitivity index) were obtained through clinical examination. The associations were assessed by linear regression analysis. The median intake of total TFA among the 393 men was 1·3 g/d, covering a daily I-TFA intake of 0·4 g (10-90th percentile 0·0-1·0) and R-TFA intake of 0·9 g (10-90th percentile 0·4-1·8). Intake of these amounts of TFA showed no significant associations with abdominal fatness, inflammatory markers, blood lipids, blood pressure and insulin homeostasis. Among middle-aged men with a generally low intake of TFA, neither I-TFA nor R-TFA was significantly related to obesity-associated risk markers of CHD. The decreased average intake of I-TFA in Denmark since 1995 is suggested to effectively prevent occurrence of the adverse metabolic changes and health consequences, which have formerly been observed in relation to, especially, I-TFA intake. ©

AB - Intake of trans-fatty acids (TFA), especially industrially produced TFA (I-TFA), has been associated with the risk of CHD through influence on serum lipid levels. Other causal pathways remain less investigated. In the present cross-sectional study of middle-aged men representing a broad range of BMI, the association between intake of TFA, I-TFA and ruminant TFA (R-TFA) and obesity-associated risk markers of CHD was assessed. The study comprised 393 Danish men (median age 49 years) with a median BMI of 28·4 kg/m 2. Intake of TFA was estimated based on 7 d dietary records, whereas outcomes of interest (waist circumference, sagittal abdominal diameter, percentage of truncal fat, C-reactive protein, IL-6, blood lipids, blood pressure, HbA1c and insulin sensitivity index) were obtained through clinical examination. The associations were assessed by linear regression analysis. The median intake of total TFA among the 393 men was 1·3 g/d, covering a daily I-TFA intake of 0·4 g (10-90th percentile 0·0-1·0) and R-TFA intake of 0·9 g (10-90th percentile 0·4-1·8). Intake of these amounts of TFA showed no significant associations with abdominal fatness, inflammatory markers, blood lipids, blood pressure and insulin homeostasis. Among middle-aged men with a generally low intake of TFA, neither I-TFA nor R-TFA was significantly related to obesity-associated risk markers of CHD. The decreased average intake of I-TFA in Denmark since 1995 is suggested to effectively prevent occurrence of the adverse metabolic changes and health consequences, which have formerly been observed in relation to, especially, I-TFA intake. ©

U2 - 10.1017/S0007114511001474

DO - 10.1017/S0007114511001474

M3 - Journal article

C2 - 21736833

SN - 0007-1145

VL - 106

SP - 1245

EP - 1252

JO - British Journal of Nutrition

JF - British Journal of Nutrition

IS - 8

ER -

A cross-sectional study on trans-fatty acids and risk markers of CHD among middle-aged men representing a broad range of BMI

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this