A comprehensive compilation of SUMO proteomics

Ivo A Hendriks; Alfred C O Vertegaal

doi:10.1038/nrm.2016.81

A comprehensive compilation of SUMO proteomics

Ivo A Hendriks, Alfred C O Vertegaal

209 Citations (Scopus)

Abstract

Small ubiquitin-like modifiers (SUMOs) are essential for the regulation of several cellular processes and are potential therapeutic targets owing to their involvement in diseases such as cancer and Alzheimer disease. In the past decade, we have witnessed a rapid expansion of proteomic approaches for identifying sumoylated proteins, with recent advances in detecting site-specific sumoylation. In this Analysis, we combined all human SUMO proteomics data currently available into one cohesive database. We provide proteomic evidence for sumoylation of 3,617 proteins at 7,327 sumoylation sites, and insight into SUMO group modification by clustering the sumoylated proteins into functional networks. The data support sumoylation being a frequent protein modification (on par with other major protein modifications) with multiple nuclear functions, including in transcription, mRNA processing, DNA replication and the DNA-damage response.

Original language	English
Journal	Nature Reviews. Molecular Cell Biology
Volume	17
Issue number	9
Pages (from-to)	581-95
Number of pages	15
ISSN	1471-0072
DOIs	https://doi.org/10.1038/nrm.2016.81
Publication status	Published - 1 Sept 2016

Keywords

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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A comprehensive compilation of SUMO proteomics

Abstract

Keywords

UN SDGs

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