A compare between myocardial topical negative pressure levels of -25 mmHg and -50 mmHg in a porcine model

Sandra Lindstedt; Per Paulsson; Arash Mokhtari; Bodil Gesslein; Joanna Hlebowicz; Malin Malmsjö; Richard Ingemansson

doi:10.1186/1471-2261-8-14

A compare between myocardial topical negative pressure levels of -25 mmHg and -50 mmHg in a porcine model

Sandra Lindstedt, Per Paulsson, Arash Mokhtari, Bodil Gesslein, Joanna Hlebowicz, Malin Malmsjö, Richard Ingemansson

Neuronal Signalling

6 Citations (Scopus)

Abstract

Topical negative pressure (TNP), widely used in wound therapy, is known to stimulate wound edge blood flow, granulation tissue formation, angiogenesis, and revascularization. We have previously shown that application of a TNP of -50 mmHg to the myocardium significantly increases microvascular blood flow in the underlying tissue. We have also shown that a myocardial TNP levels between -75 mmHg and -150 mmHg do not induce microvascular blood flow changes in the underlying myocardium. The present study was designed to elucidate the difference between -25 mmHg and -50 mmHg TNP on microvascular flow in normal and ischemic myocardium.

Original language	English
Journal	B M C Cardiovascular Disorders
Volume	8
Pages (from-to)	14
ISSN	1471-2261
DOIs	https://doi.org/10.1186/1471-2261-8-14
Publication status	Published - 2008

Keywords

Animals
Coronary Artery Disease
Coronary Circulation
Coronary Vessels
Laser-Doppler Flowmetry
Myocardium
Negative-Pressure Wound Therapy
Pressure
Regional Blood Flow
Reperfusion Injury
Sternum
Swine

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title = "A compare between myocardial topical negative pressure levels of -25 mmHg and -50 mmHg in a porcine model",

abstract = "Topical negative pressure (TNP), widely used in wound therapy, is known to stimulate wound edge blood flow, granulation tissue formation, angiogenesis, and revascularization. We have previously shown that application of a TNP of -50 mmHg to the myocardium significantly increases microvascular blood flow in the underlying tissue. We have also shown that a myocardial TNP levels between -75 mmHg and -150 mmHg do not induce microvascular blood flow changes in the underlying myocardium. The present study was designed to elucidate the difference between -25 mmHg and -50 mmHg TNP on microvascular flow in normal and ischemic myocardium.",

keywords = "Animals, Coronary Artery Disease, Coronary Circulation, Coronary Vessels, Laser-Doppler Flowmetry, Myocardium, Negative-Pressure Wound Therapy, Pressure, Regional Blood Flow, Reperfusion Injury, Sternum, Swine",

author = "Sandra Lindstedt and Per Paulsson and Arash Mokhtari and Bodil Gesslein and Joanna Hlebowicz and Malin Malmsj{\"o} and Richard Ingemansson",

year = "2008",

doi = "10.1186/1471-2261-8-14",

language = "English",

volume = "8",

pages = "14",

journal = "B M C Cardiovascular Disorders",

issn = "1471-2261",

publisher = "BioMed Central Ltd.",

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TY - JOUR

T1 - A compare between myocardial topical negative pressure levels of -25 mmHg and -50 mmHg in a porcine model

AU - Lindstedt, Sandra

AU - Paulsson, Per

AU - Mokhtari, Arash

AU - Gesslein, Bodil

AU - Hlebowicz, Joanna

AU - Malmsjö, Malin

AU - Ingemansson, Richard

PY - 2008

Y1 - 2008

N2 - Topical negative pressure (TNP), widely used in wound therapy, is known to stimulate wound edge blood flow, granulation tissue formation, angiogenesis, and revascularization. We have previously shown that application of a TNP of -50 mmHg to the myocardium significantly increases microvascular blood flow in the underlying tissue. We have also shown that a myocardial TNP levels between -75 mmHg and -150 mmHg do not induce microvascular blood flow changes in the underlying myocardium. The present study was designed to elucidate the difference between -25 mmHg and -50 mmHg TNP on microvascular flow in normal and ischemic myocardium.

AB - Topical negative pressure (TNP), widely used in wound therapy, is known to stimulate wound edge blood flow, granulation tissue formation, angiogenesis, and revascularization. We have previously shown that application of a TNP of -50 mmHg to the myocardium significantly increases microvascular blood flow in the underlying tissue. We have also shown that a myocardial TNP levels between -75 mmHg and -150 mmHg do not induce microvascular blood flow changes in the underlying myocardium. The present study was designed to elucidate the difference between -25 mmHg and -50 mmHg TNP on microvascular flow in normal and ischemic myocardium.

KW - Animals

KW - Coronary Artery Disease

KW - Coronary Circulation

KW - Coronary Vessels

KW - Laser-Doppler Flowmetry

KW - Myocardium

KW - Negative-Pressure Wound Therapy

KW - Pressure

KW - Regional Blood Flow

KW - Reperfusion Injury

KW - Sternum

KW - Swine

U2 - 10.1186/1471-2261-8-14

DO - 10.1186/1471-2261-8-14

M3 - Journal article

C2 - 18570679

SN - 1471-2261

VL - 8

SP - 14

JO - B M C Cardiovascular Disorders

JF - B M C Cardiovascular Disorders

ER -

A compare between myocardial topical negative pressure levels of -25 mmHg and -50 mmHg in a porcine model

Abstract

Keywords

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