A comparative study of the FcepsilonRI molecule on human mast cell and basophil cell lines

Bettina Margrethe Jensen; S Dissing; P S Skov; L K Poulsen

doi:http://dx.doi.org/10.1159/000085464

A comparative study of the FcepsilonRI molecule on human mast cell and basophil cell lines

Bettina Margrethe Jensen, S Dissing, P S Skov, L K Poulsen

8 Citations (Scopus)

Abstract

Mast cells and basophils express the high-affinity IgE receptor FcepsilonRI. We have analysed the human mast cell line LAD2 and four subclones of the basophil cell line KU812 in order to reveal possible differences concerning the FcepsilonRI surface regulation, anti-IgE-triggered activation, FcepsilonRIalpha protein stability and the mRNA level of FcepsilonRIalpha-, beta- and the truncated beta-chain (beta(T)), and thereby determine the utility of these cell lines in investigations of the FcepsilonRI biology.

Original language	English
Journal	International Archives of Allergy and Immunology
Volume	137
Issue number	2
Pages (from-to)	93-103
Number of pages	11
ISSN	1018-2438
DOIs	https://doi.org/10.1159/000085464
Publication status	Published - 2005

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title = "A comparative study of the FcepsilonRI molecule on human mast cell and basophil cell lines",

abstract = "Mast cells and basophils express the high-affinity IgE receptor FcepsilonRI. We have analysed the human mast cell line LAD2 and four subclones of the basophil cell line KU812 in order to reveal possible differences concerning the FcepsilonRI surface regulation, anti-IgE-triggered activation, FcepsilonRIalpha protein stability and the mRNA level of FcepsilonRIalpha-, beta- and the truncated beta-chain (beta(T)), and thereby determine the utility of these cell lines in investigations of the FcepsilonRI biology.",

author = "Jensen, {Bettina Margrethe} and S Dissing and Skov, {P S} and Poulsen, {L K}",

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AU - Jensen, Bettina Margrethe

AU - Dissing, S

AU - Skov, P S

AU - Poulsen, L K

PY - 2005

Y1 - 2005

N2 - Mast cells and basophils express the high-affinity IgE receptor FcepsilonRI. We have analysed the human mast cell line LAD2 and four subclones of the basophil cell line KU812 in order to reveal possible differences concerning the FcepsilonRI surface regulation, anti-IgE-triggered activation, FcepsilonRIalpha protein stability and the mRNA level of FcepsilonRIalpha-, beta- and the truncated beta-chain (beta(T)), and thereby determine the utility of these cell lines in investigations of the FcepsilonRI biology.

AB - Mast cells and basophils express the high-affinity IgE receptor FcepsilonRI. We have analysed the human mast cell line LAD2 and four subclones of the basophil cell line KU812 in order to reveal possible differences concerning the FcepsilonRI surface regulation, anti-IgE-triggered activation, FcepsilonRIalpha protein stability and the mRNA level of FcepsilonRIalpha-, beta- and the truncated beta-chain (beta(T)), and thereby determine the utility of these cell lines in investigations of the FcepsilonRI biology.

U2 - http://dx.doi.org/10.1159/000085464

DO - http://dx.doi.org/10.1159/000085464

M3 - Journal article

SN - 1018-2438

VL - 137

SP - 93

EP - 103

JO - International Archives of Allergy and Immunology

JF - International Archives of Allergy and Immunology

IS - 2

ER -

A comparative study of the FcepsilonRI molecule on human mast cell and basophil cell lines

Abstract

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