A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation

R Graham Barr; Eugene A Berkowitz; Francesca Bigazzi; Frederick Bode; Jessica Bon; Russell P Bowler; Caroline Chiles; James D Crapo; Gerard J Criner; Jeffrey L Curtis; Chandra Dass; Asger Dirksen; Mark T Dransfield; Goutham Edula; Leif Erikkson; Adam Friedlander; Maya Galperin-Aizenberg; Warren B Gefter; David S Gierada; Philippe A Grenier; Jonathan Goldin; MeiLan K Han; Nicola A Hanania; Nadia N Hansel; Francine L Jacobson; Hans-Ulrich Kauczor; Vuokko L Kinnula; David A Lipson; David A Lynch; William MacNee; Barry J Make; A James Mamary; Howard Mann; Nathaniel Marchetti; Mario Mascalchi; Geoffrey McLennan; James R Murphy; David Naidich; Hrudaya Nath; John D Newell; Massimo Pistolesi; Elizabeth A Regan; John J Reilly; Robert Sandhaus; Joyce D Schroeder; Frank Sciurba; Saher Shaker; Amir Sharafkhaneh; Edwin K Silverman; Robert M Steiner; COPDGene CT Workshop Group

doi:10.3109/15412555.2012.654923

A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation

R Graham Barr, Eugene A Berkowitz, Francesca Bigazzi, Frederick Bode, Jessica Bon, Russell P Bowler, Caroline Chiles, James D Crapo, Gerard J Criner, Jeffrey L Curtis, Chandra Dass, Asger Dirksen, Mark T Dransfield, Goutham Edula, Leif Erikkson, Adam Friedlander, Maya Galperin-Aizenberg, Warren B Gefter, David S Gierada, Philippe A GrenierJonathan Goldin, MeiLan K Han, Nicola A Hanania, Nadia N Hansel, Francine L Jacobson, Hans-Ulrich Kauczor, Vuokko L Kinnula, David A Lipson, David A Lynch, William MacNee, Barry J Make, A James Mamary, Howard Mann, Nathaniel Marchetti, Mario Mascalchi, Geoffrey McLennan, James R Murphy, David Naidich, Hrudaya Nath, John D Newell, Massimo Pistolesi, Elizabeth A Regan, John J Reilly, Robert Sandhaus, Joyce D Schroeder, Frank Sciurba, Saher Shaker, Amir Sharafkhaneh, Edwin K Silverman, Robert M Steiner, COPDGene CT Workshop Group

Section 04 - Forensic Odontology

107 Citations (Scopus)

Abstract

The purposes of this study were: to describe chest CT findings in normal non-smoking controls and cigarette smokers with and without COPD; to compare the prevalence of CT abnormalities with severity of COPD; and to evaluate concordance between visual and quantitative chest CT (QCT) scoring. Methods: Volumetric inspiratory and expiratory CT scans of 294 subjects, including normal non-smokers, smokers without COPD, and smokers with GOLD Stage I-IV COPD, were scored at a multi-reader workshop using a standardized worksheet. There were 58 observers (33 pulmonologists, 25 radiologists); each scan was scored by 9-11 observers. Interobserver agreement was calculated using kappa statistic. Median score of visual observations was compared with QCT measurements. Results: Interobserver agreement was moderate for the presence or absence of emphysema and for the presence of panlobular emphysema; fair for the presence of centrilobular, paraseptal, and bullous emphysema subtypes and for the presence of bronchial wall thickening; and poor for gas trapping, centrilobular nodularity, mosaic attenuation, and bronchial dilation. Agreement was similar for radiologists and pulmonologists. The prevalence on CT readings of most abnormalities (e.g. emphysema, bronchial wall thickening, mosaic attenuation, expiratory gas trapping) increased significantly with greater COPD severity, while the prevalence of centrilobular nodularity decreased. Concordances between visual scoring and quantitative scoring of emphysema, gas trapping and airway wall thickening were 75%, 87% and 65%, respectively. Conclusions: Despite substantial inter-observer variation, visual assessment of chest CT scans in cigarette smokers provides information regarding lung disease severity; visual scoring may be complementary to quantitative evaluation.

Original language	English
Journal	C O P D
Volume	9
Issue number	2
Pages (from-to)	151-9
Number of pages	9
ISSN	1541-2555
DOIs	https://doi.org/10.3109/15412555.2012.654923
Publication status	Published - Apr 2012

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Barr, R. G., Berkowitz, E. A., Bigazzi, F., Bode, F., Bon, J., Bowler, R. P., Chiles, C., Crapo, J. D., Criner, G. J., Curtis, J. L., Dass, C., Dirksen, A., Dransfield, M. T., Edula, G., Erikkson, L., Friedlander, A., Galperin-Aizenberg, M., Gefter, W. B., Gierada, D. S., ... COPDGene CT Workshop Group (2012). A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation. C O P D, 9(2), 151-9. https://doi.org/10.3109/15412555.2012.654923

Barr, RG, Berkowitz, EA, Bigazzi, F, Bode, F, Bon, J, Bowler, RP, Chiles, C, Crapo, JD, Criner, GJ, Curtis, JL, Dass, C, Dirksen, A, Dransfield, MT, Edula, G, Erikkson, L, Friedlander, A, Galperin-Aizenberg, M, Gefter, WB, Gierada, DS, Grenier, PA, Goldin, J, Han, MK, Hanania, NA, Hansel, NN, Jacobson, FL, Kauczor, H-U, Kinnula, VL, Lipson, DA, Lynch, DA, MacNee, W, Make, BJ, Mamary, AJ, Mann, H, Marchetti, N, Mascalchi, M, McLennan, G, Murphy, JR, Naidich, D, Nath, H, Newell, JD, Pistolesi, M, Regan, EA, Reilly, JJ, Sandhaus, R, Schroeder, JD, Sciurba, F, Shaker, S, Sharafkhaneh, A, Silverman, EK, Steiner, RM & COPDGene CT Workshop Group 2012, 'A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation', C O P D, vol. 9, no. 2, pp. 151-9. https://doi.org/10.3109/15412555.2012.654923

@article{25a355a915a548bb817cf3765dfbd9ed,

title = "A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation",

abstract = "The purposes of this study were: to describe chest CT findings in normal non-smoking controls and cigarette smokers with and without COPD; to compare the prevalence of CT abnormalities with severity of COPD; and to evaluate concordance between visual and quantitative chest CT (QCT) scoring. Methods: Volumetric inspiratory and expiratory CT scans of 294 subjects, including normal non-smokers, smokers without COPD, and smokers with GOLD Stage I-IV COPD, were scored at a multi-reader workshop using a standardized worksheet. There were 58 observers (33 pulmonologists, 25 radiologists); each scan was scored by 9-11 observers. Interobserver agreement was calculated using kappa statistic. Median score of visual observations was compared with QCT measurements. Results: Interobserver agreement was moderate for the presence or absence of emphysema and for the presence of panlobular emphysema; fair for the presence of centrilobular, paraseptal, and bullous emphysema subtypes and for the presence of bronchial wall thickening; and poor for gas trapping, centrilobular nodularity, mosaic attenuation, and bronchial dilation. Agreement was similar for radiologists and pulmonologists. The prevalence on CT readings of most abnormalities (e.g. emphysema, bronchial wall thickening, mosaic attenuation, expiratory gas trapping) increased significantly with greater COPD severity, while the prevalence of centrilobular nodularity decreased. Concordances between visual scoring and quantitative scoring of emphysema, gas trapping and airway wall thickening were 75%, 87% and 65%, respectively. Conclusions: Despite substantial inter-observer variation, visual assessment of chest CT scans in cigarette smokers provides information regarding lung disease severity; visual scoring may be complementary to quantitative evaluation.",

author = "Barr, {R Graham} and Berkowitz, {Eugene A} and Francesca Bigazzi and Frederick Bode and Jessica Bon and Bowler, {Russell P} and Caroline Chiles and Crapo, {James D} and Criner, {Gerard J} and Curtis, {Jeffrey L} and Chandra Dass and Asger Dirksen and Dransfield, {Mark T} and Goutham Edula and Leif Erikkson and Adam Friedlander and Maya Galperin-Aizenberg and Gefter, {Warren B} and Gierada, {David S} and Grenier, {Philippe A} and Jonathan Goldin and Han, {MeiLan K} and Hanania, {Nicola A} and Hansel, {Nadia N} and Jacobson, {Francine L} and Hans-Ulrich Kauczor and Kinnula, {Vuokko L} and Lipson, {David A} and Lynch, {David A} and William MacNee and Make, {Barry J} and Mamary, {A James} and Howard Mann and Nathaniel Marchetti and Mario Mascalchi and Geoffrey McLennan and Murphy, {James R} and David Naidich and Hrudaya Nath and Newell, {John D} and Massimo Pistolesi and Regan, {Elizabeth A} and Reilly, {John J} and Robert Sandhaus and Schroeder, {Joyce D} and Frank Sciurba and Saher Shaker and Amir Sharafkhaneh and Silverman, {Edwin K} and Steiner, {Robert M} and Asger Dirksen",

year = "2012",

month = apr,

doi = "10.3109/15412555.2012.654923",

language = "English",

volume = "9",

pages = "151--9",

journal = "C O P D",

issn = "1541-2555",

publisher = "Taylor & Francis",

number = "2",

}

TY - JOUR

T1 - A combined pulmonary-radiology workshop for visual evaluation of COPD

T2 - study design, chest CT findings and concordance with quantitative evaluation

AU - Barr, R Graham

AU - Berkowitz, Eugene A

AU - Bigazzi, Francesca

AU - Bode, Frederick

AU - Bon, Jessica

AU - Bowler, Russell P

AU - Chiles, Caroline

AU - Crapo, James D

AU - Criner, Gerard J

AU - Curtis, Jeffrey L

AU - Dass, Chandra

AU - Dirksen, Asger

AU - Dransfield, Mark T

AU - Edula, Goutham

AU - Erikkson, Leif

AU - Friedlander, Adam

AU - Galperin-Aizenberg, Maya

AU - Gefter, Warren B

AU - Gierada, David S

AU - Grenier, Philippe A

AU - Goldin, Jonathan

AU - Han, MeiLan K

AU - Hanania, Nicola A

AU - Hansel, Nadia N

AU - Jacobson, Francine L

AU - Kauczor, Hans-Ulrich

AU - Kinnula, Vuokko L

AU - Lipson, David A

AU - Lynch, David A

AU - MacNee, William

AU - Make, Barry J

AU - Mamary, A James

AU - Mann, Howard

AU - Marchetti, Nathaniel

AU - Mascalchi, Mario

AU - McLennan, Geoffrey

AU - Murphy, James R

AU - Naidich, David

AU - Nath, Hrudaya

AU - Newell, John D

AU - Pistolesi, Massimo

AU - Regan, Elizabeth A

AU - Reilly, John J

AU - Sandhaus, Robert

AU - Schroeder, Joyce D

AU - Sciurba, Frank

AU - Shaker, Saher

AU - Sharafkhaneh, Amir

AU - Silverman, Edwin K

AU - Steiner, Robert M

AU - COPDGene CT Workshop Group

PY - 2012/4

Y1 - 2012/4

N2 - The purposes of this study were: to describe chest CT findings in normal non-smoking controls and cigarette smokers with and without COPD; to compare the prevalence of CT abnormalities with severity of COPD; and to evaluate concordance between visual and quantitative chest CT (QCT) scoring. Methods: Volumetric inspiratory and expiratory CT scans of 294 subjects, including normal non-smokers, smokers without COPD, and smokers with GOLD Stage I-IV COPD, were scored at a multi-reader workshop using a standardized worksheet. There were 58 observers (33 pulmonologists, 25 radiologists); each scan was scored by 9-11 observers. Interobserver agreement was calculated using kappa statistic. Median score of visual observations was compared with QCT measurements. Results: Interobserver agreement was moderate for the presence or absence of emphysema and for the presence of panlobular emphysema; fair for the presence of centrilobular, paraseptal, and bullous emphysema subtypes and for the presence of bronchial wall thickening; and poor for gas trapping, centrilobular nodularity, mosaic attenuation, and bronchial dilation. Agreement was similar for radiologists and pulmonologists. The prevalence on CT readings of most abnormalities (e.g. emphysema, bronchial wall thickening, mosaic attenuation, expiratory gas trapping) increased significantly with greater COPD severity, while the prevalence of centrilobular nodularity decreased. Concordances between visual scoring and quantitative scoring of emphysema, gas trapping and airway wall thickening were 75%, 87% and 65%, respectively. Conclusions: Despite substantial inter-observer variation, visual assessment of chest CT scans in cigarette smokers provides information regarding lung disease severity; visual scoring may be complementary to quantitative evaluation.

AB - The purposes of this study were: to describe chest CT findings in normal non-smoking controls and cigarette smokers with and without COPD; to compare the prevalence of CT abnormalities with severity of COPD; and to evaluate concordance between visual and quantitative chest CT (QCT) scoring. Methods: Volumetric inspiratory and expiratory CT scans of 294 subjects, including normal non-smokers, smokers without COPD, and smokers with GOLD Stage I-IV COPD, were scored at a multi-reader workshop using a standardized worksheet. There were 58 observers (33 pulmonologists, 25 radiologists); each scan was scored by 9-11 observers. Interobserver agreement was calculated using kappa statistic. Median score of visual observations was compared with QCT measurements. Results: Interobserver agreement was moderate for the presence or absence of emphysema and for the presence of panlobular emphysema; fair for the presence of centrilobular, paraseptal, and bullous emphysema subtypes and for the presence of bronchial wall thickening; and poor for gas trapping, centrilobular nodularity, mosaic attenuation, and bronchial dilation. Agreement was similar for radiologists and pulmonologists. The prevalence on CT readings of most abnormalities (e.g. emphysema, bronchial wall thickening, mosaic attenuation, expiratory gas trapping) increased significantly with greater COPD severity, while the prevalence of centrilobular nodularity decreased. Concordances between visual scoring and quantitative scoring of emphysema, gas trapping and airway wall thickening were 75%, 87% and 65%, respectively. Conclusions: Despite substantial inter-observer variation, visual assessment of chest CT scans in cigarette smokers provides information regarding lung disease severity; visual scoring may be complementary to quantitative evaluation.

U2 - 10.3109/15412555.2012.654923

DO - 10.3109/15412555.2012.654923

M3 - Journal article

C2 - 22429093

SN - 1541-2555

VL - 9

SP - 151

EP - 159

JO - C O P D

JF - C O P D

IS - 2

ER -

A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation

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