A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks

Till Bartke; Anja Groth

doi:10.1080/23723556.2019.1605820

A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks

Till Bartke, Anja Groth

Novo Nordisk Foundation Center for Protein Research

3 Citations (Scopus)

33 Downloads (Pure)

Abstract

Mutations caused by DNA damage are a main driver of cancer. We discovered that recognition of newly synthesised histone H4 directs breast cancer type 1 susceptibility protein (BRCA1) to post-replicative chromatin. The switch from mutagenic to error-free DNA double strand break repair by homologous recombination is therefore controlled by chromatin.

Original language	English
Article number	1605820
Journal	Molecular & Cellular Oncology
Volume	6
Issue number	4
Number of pages	3
ISSN	2372-3556
DOIs	https://doi.org/10.1080/23723556.2019.1605820
Publication status	Published - 4 Jul 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/23723556.2019.1605820Licence: CC BY-NC-ND

A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaksFinal published version, 1.22 MBLicence: CC BY-NC-ND

Cite this

@article{2557e1d07bf142e19d616990ed7707bd,

title = "A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks",

abstract = "Mutations caused by DNA damage are a main driver of cancer. We discovered that recognition of newly synthesised histone H4 directs breast cancer type 1 susceptibility protein (BRCA1) to post-replicative chromatin. The switch from mutagenic to error-free DNA double strand break repair by homologous recombination is therefore controlled by chromatin.",

author = "Till Bartke and Anja Groth",

year = "2019",

month = jul,

day = "4",

doi = "10.1080/23723556.2019.1605820",

language = "English",

volume = "6",

journal = "Molecular and Cellular Oncology",

issn = "2372-3556",

publisher = "Taylor & Francis",

number = "4",

}

TY - JOUR

T1 - A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks

AU - Bartke, Till

AU - Groth, Anja

PY - 2019/7/4

Y1 - 2019/7/4

N2 - Mutations caused by DNA damage are a main driver of cancer. We discovered that recognition of newly synthesised histone H4 directs breast cancer type 1 susceptibility protein (BRCA1) to post-replicative chromatin. The switch from mutagenic to error-free DNA double strand break repair by homologous recombination is therefore controlled by chromatin.

AB - Mutations caused by DNA damage are a main driver of cancer. We discovered that recognition of newly synthesised histone H4 directs breast cancer type 1 susceptibility protein (BRCA1) to post-replicative chromatin. The switch from mutagenic to error-free DNA double strand break repair by homologous recombination is therefore controlled by chromatin.

U2 - 10.1080/23723556.2019.1605820

DO - 10.1080/23723556.2019.1605820

M3 - Journal article

C2 - 31211233

SN - 2372-3556

VL - 6

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 4

M1 - 1605820

ER -

A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this