Abstract
3'-deoxy-3'-[¹⁸F]fluorothymidine ([18F]FLT) is a tracer used to assess cell proliferation in vivo. The aim of the study was to use [18F]FLT positron emission tomography (PET) to study non-invasively early anti-proliferative effects of the experimental chemotherapeutic agent TP202377 in both sensitive and resistant tumors.
Original language | English |
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Article number | e50618 |
Journal | P L o S One |
Volume | 7 |
Issue number | 11 |
Pages (from-to) | e50618 |
ISSN | 1932-6203 |
DOIs | |
Publication status | Published - 2012 |
Keywords
- Animals
- Antineoplastic Agents
- Biological Transport
- Cell Line, Tumor
- Cell Proliferation
- Dideoxynucleosides
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Indoles
- Ki-67 Antigen
- Mice
- Ovarian Neoplasms
- Positron-Emission Tomography
- Thymidine Kinase
- Time Factors
- Tomography, X-Ray Computed
- Treatment Failure
- Tumor Burden
- Xenograft Model Antitumor Assays