11q13 is a Susceptibility Locus for Hormone Receptor Positive Breast Cancer

Diether Lambrechts; Therese Truong; Christina Justenhoven; Manjeet K Humphreys; Jean Wang; John L Hopper; Gillian S Dite; Carmel Apicella; Melissa C Southey; Marjanka K Schmidt; Annegien Broeks; Sten Cornelissen; Richard van Hien; Elinor Sawyer; Ian Tomlinson; Michael Kerin; Nicola Miller; Roger L Milne; M Pilar Zamora; José Ignacio Arias Pérez; Javier Benítez; Ute Hamann; Yon-Dschun Ko; Thomas Brüning; Jenny Chang-Claude; Ursel Eilber; Rebecca Hein; Stefan Nickels; Dieter Flesch-Janys; Shan Wang-Gohrke; Esther M John; Alexander Miron; Robert Winqvist; Katri Pylkäs; Arja Jukkola-Vuorinen; Mervi Grip; Georgia Chenevix-Trench; Jonathan Beesley; Xiaoqing Chen; Florence Menegaux; Emilie Cordina-Duverger; Chen-Yang Shen; Jyh-Cherng Yu; Pei-Ei Wu; Ming-Feng Hou; Irene L Andrulis; Teresa Selander; Børge G Nordestgaard; Stig E Bojesen; Charlotte Lanng; The GENICA Network

doi:10.1002/humu.22089

11q13 is a Susceptibility Locus for Hormone Receptor Positive Breast Cancer

Diether Lambrechts, Therese Truong, Christina Justenhoven, Manjeet K Humphreys, Jean Wang, John L Hopper, Gillian S Dite, Carmel Apicella, Melissa C Southey, Marjanka K Schmidt, Annegien Broeks, Sten Cornelissen, Richard van Hien, Elinor Sawyer, Ian Tomlinson, Michael Kerin, Nicola Miller, Roger L Milne, M Pilar Zamora, José Ignacio Arias PérezJavier Benítez, Ute Hamann, Yon-Dschun Ko, Thomas Brüning, Jenny Chang-Claude, Ursel Eilber, Rebecca Hein, Stefan Nickels, Dieter Flesch-Janys, Shan Wang-Gohrke, Esther M John, Alexander Miron, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Georgia Chenevix-Trench, Jonathan Beesley, Xiaoqing Chen, Florence Menegaux, Emilie Cordina-Duverger, Chen-Yang Shen, Jyh-Cherng Yu, Pei-Ei Wu, Ming-Feng Hou, Irene L Andrulis, Teresa Selander, Børge G Nordestgaard, Stig E Bojesen, Charlotte Lanng, The GENICA Network

33 Citations (Scopus)

Abstract

A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, and rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P ≤ 3 × 10^-9) and weak evidence was observed for rs2380205 (P = 0.06). The strongest evidence was obtained for rs614367, located on 11q13 (per-allele odds ratio 1.21, P = 4 × 10^-39). The association for rs614367 was specific to estrogen receptor (ER)-positive disease and strongest for ER plus progesterone receptor (PR)-positive breast cancer, whereas the associations for the other three loci did not differ by tumor subtype.

Original language	English
Journal	Human Mutation
ISSN	1059-7794
DOIs	https://doi.org/10.1002/humu.22089
Publication status	Published - Jul 2012

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Lambrechts, D., Truong, T., Justenhoven, C., Humphreys, M. K., Wang, J., Hopper, J. L., Dite, G. S., Apicella, C., Southey, M. C., Schmidt, M. K., Broeks, A., Cornelissen, S., Hien, R. V., Sawyer, E., Tomlinson, I., Kerin, M., Miller, N., Milne, R. L., Zamora, M. P., ... The GENICA Network (2012). 11q13 is a Susceptibility Locus for Hormone Receptor Positive Breast Cancer. Human Mutation. https://doi.org/10.1002/humu.22089

Lambrechts, D, Truong, T, Justenhoven, C, Humphreys, MK, Wang, J, Hopper, JL, Dite, GS, Apicella, C, Southey, MC, Schmidt, MK, Broeks, A, Cornelissen, S, Hien, RV, Sawyer, E, Tomlinson, I, Kerin, M, Miller, N, Milne, RL, Zamora, MP, Pérez, JIA, Benítez, J, Hamann, U, Ko, Y-D, Brüning, T, Chang-Claude, J, Eilber, U, Hein, R, Nickels, S, Flesch-Janys, D, Wang-Gohrke, S, John, EM, Miron, A, Winqvist, R, Pylkäs, K, Jukkola-Vuorinen, A, Grip, M, Chenevix-Trench, G, Beesley, J, Chen, X, Menegaux, F, Cordina-Duverger, E, Shen, C-Y, Yu, J-C, Wu, P-E, Hou, M-F, Andrulis, IL, Selander, T, Nordestgaard, BG , Bojesen, SE, Lanng, C & The GENICA Network 2012, '11q13 is a Susceptibility Locus for Hormone Receptor Positive Breast Cancer', Human Mutation. https://doi.org/10.1002/humu.22089

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title = "11q13 is a Susceptibility Locus for Hormone Receptor Positive Breast Cancer",

abstract = "A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, and rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P ≤ 3 × 10-9) and weak evidence was observed for rs2380205 (P = 0.06). The strongest evidence was obtained for rs614367, located on 11q13 (per-allele odds ratio 1.21, P = 4 × 10-39). The association for rs614367 was specific to estrogen receptor (ER)-positive disease and strongest for ER plus progesterone receptor (PR)-positive breast cancer, whereas the associations for the other three loci did not differ by tumor subtype.",

author = "Diether Lambrechts and Therese Truong and Christina Justenhoven and Humphreys, {Manjeet K} and Jean Wang and Hopper, {John L} and Dite, {Gillian S} and Carmel Apicella and Southey, {Melissa C} and Schmidt, {Marjanka K} and Annegien Broeks and Sten Cornelissen and Hien, {Richard van} and Elinor Sawyer and Ian Tomlinson and Michael Kerin and Nicola Miller and Milne, {Roger L} and Zamora, {M Pilar} and P{\'e}rez, {Jos{\'e} Ignacio Arias} and Javier Ben{\'i}tez and Ute Hamann and Yon-Dschun Ko and Thomas Br{\"u}ning and Jenny Chang-Claude and Ursel Eilber and Rebecca Hein and Stefan Nickels and Dieter Flesch-Janys and Shan Wang-Gohrke and John, {Esther M} and Alexander Miron and Robert Winqvist and Katri Pylk{\"a}s and Arja Jukkola-Vuorinen and Mervi Grip and Georgia Chenevix-Trench and Jonathan Beesley and Xiaoqing Chen and Florence Menegaux and Emilie Cordina-Duverger and Chen-Yang Shen and Jyh-Cherng Yu and Pei-Ei Wu and Ming-Feng Hou and Andrulis, {Irene L} and Teresa Selander and Nordestgaard, {B{\o}rge G} and Bojesen, {Stig E} and Charlotte Lanng and B{\o}rge Nordestgaard",

note = "{\textcopyright} 2012 Wiley Periodicals, Inc.",

year = "2012",

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doi = "10.1002/humu.22089",

language = "English",

journal = "Human Mutation",

issn = "1059-7794",

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TY - JOUR

T1 - 11q13 is a Susceptibility Locus for Hormone Receptor Positive Breast Cancer

AU - Lambrechts, Diether

AU - Truong, Therese

AU - Justenhoven, Christina

AU - Humphreys, Manjeet K

AU - Wang, Jean

AU - Hopper, John L

AU - Dite, Gillian S

AU - Apicella, Carmel

AU - Southey, Melissa C

AU - Schmidt, Marjanka K

AU - Broeks, Annegien

AU - Cornelissen, Sten

AU - Hien, Richard van

AU - Sawyer, Elinor

AU - Tomlinson, Ian

AU - Kerin, Michael

AU - Miller, Nicola

AU - Milne, Roger L

AU - Zamora, M Pilar

AU - Pérez, José Ignacio Arias

AU - Benítez, Javier

AU - Hamann, Ute

AU - Ko, Yon-Dschun

AU - Brüning, Thomas

AU - Chang-Claude, Jenny

AU - Eilber, Ursel

AU - Hein, Rebecca

AU - Nickels, Stefan

AU - Flesch-Janys, Dieter

AU - Wang-Gohrke, Shan

AU - John, Esther M

AU - Miron, Alexander

AU - Winqvist, Robert

AU - Pylkäs, Katri

AU - Jukkola-Vuorinen, Arja

AU - Grip, Mervi

AU - Chenevix-Trench, Georgia

AU - Beesley, Jonathan

AU - Chen, Xiaoqing

AU - Menegaux, Florence

AU - Cordina-Duverger, Emilie

AU - Shen, Chen-Yang

AU - Yu, Jyh-Cherng

AU - Wu, Pei-Ei

AU - Hou, Ming-Feng

AU - Andrulis, Irene L

AU - Selander, Teresa

AU - Nordestgaard, Børge G

AU - Bojesen, Stig E

AU - Lanng, Charlotte

AU - The GENICA Network

PY - 2012/7

Y1 - 2012/7

N2 - A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, and rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P ≤ 3 × 10-9) and weak evidence was observed for rs2380205 (P = 0.06). The strongest evidence was obtained for rs614367, located on 11q13 (per-allele odds ratio 1.21, P = 4 × 10-39). The association for rs614367 was specific to estrogen receptor (ER)-positive disease and strongest for ER plus progesterone receptor (PR)-positive breast cancer, whereas the associations for the other three loci did not differ by tumor subtype.

AB - A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these loci and investigate possible heterogeneity by subtype of breast cancer, we genotyped the variants rs2380205, rs1011970, rs704010, rs614367, and rs10995190 in 39 studies from the Breast Cancer Association Consortium (BCAC), involving 49,608 cases and 48,772 controls of predominantly European ancestry. Four of the variants showed clear evidence of association (P ≤ 3 × 10-9) and weak evidence was observed for rs2380205 (P = 0.06). The strongest evidence was obtained for rs614367, located on 11q13 (per-allele odds ratio 1.21, P = 4 × 10-39). The association for rs614367 was specific to estrogen receptor (ER)-positive disease and strongest for ER plus progesterone receptor (PR)-positive breast cancer, whereas the associations for the other three loci did not differ by tumor subtype.

U2 - 10.1002/humu.22089

DO - 10.1002/humu.22089

M3 - Journal article

C2 - 22461340

SN - 1059-7794

JO - Human Mutation

JF - Human Mutation

ER -

11q13 is a Susceptibility Locus for Hormone Receptor Positive Breast Cancer

Abstract

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