No photo of Thomas Werge
20022021

Research activity per year

Search results

  • 2018

    Prevalence of rearrangements in the 22q11.2 region and population-based risk of neuropsychiatric and developmental disorders in a Danish population: a case-cohort study

    Olsen, L., Sparsø, T., Weinsheimer, S. M., Dos Santos, M. B. Q., Mazin, W., Rosengren, A., Sanchez, X. C., Hoeffding, L. K., Schmock, H., Baekvad-Hansen, M., Bybjerg-Grauholm, J., Daly, M. J., Neale, B. M., Pedersen, M. G., Agerbo, E., Mors, O., Børglum, A., Nordentoft, M., Hougaard, D. M., Mortensen, P. B., & 4 othersGeschwind, D. H., Pedersen, C., Thompson, W. K. & Werge, T., 2018, In: The Lancet Psychiatry. 5, 7, p. 573-580 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

    35 Citations (Scopus)
  • Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum

    Ganna, A., Satterstrom, F. K., Zekavat, S. M., Das, I., Kurki, M. I., Churchhouse, C., Alfoldi, J., Martin, A. R., Havulinna, A. S., Byrnes, A., Thompson, W. K., Nielsen, P. R., Karczewski, K. J., Saarentaus, E., Rivas, M. A., Gupta, N., Pietiläinen, O., Emdin, C. A., Lescai, F., Bybjerg-Grauholm, J., & 28 othersFlannick, J., GoT2D/T2D-GENES Consortium, Mercader, J. M., Udler, M., SIGMA Consortium Helmsley IBD Exome Sequencing Project, FinMetSeq Consortium, iPSYCH-Broad Consortium, Laakso, M., Salomaa, V., Hultman, C., Ripatti, S., Hämäläinen, E., Moilanen, J. S., Körkkö, J., Kuismin, O., Nordentoft, M., Hougaard, D. M., Mors, O., Werge, T., Mortensen, P. B., MacArthur, D., Daly, M. J., Sullivan, P. F., Locke, A. E., Palotie, A., Børglum, A. D., Kathiresan, S. & Neale, B. M., 2018, In: American Journal of Human Genetics. 102, 6, p. 1204-1211

    Research output: Contribution to journalJournal articleResearchpeer-review

    36 Citations (Scopus)
  • Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors

    Didriksen, M., Allen, R. P., Burchell, B. J., Thørner, L. W., Rigas, A. S., Di Angelantonio, E., Nielsen, M. H., Jennum, P. J., Werge, T., Erikstrup, C., Pedersen, O. B., Nielsen, K., Bruun, M. T., Burgdorf, K. S., Sørensen, E. & Ullum, H., May 2018, In: Sleep Medicine. 45, p. 124-131 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

    8 Citations (Scopus)
  • Schizophrenia-associated mt-DNA SNPs exhibit highly variable haplogroup affiliation and nuclear ancestry: Bi-genomic dependence raises major concerns for link to disease

    Hagen, C. M., Gonçalves, V. F., Hedley, P. L., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Hansen, C. S., Kanters, J. K., Nielsen, J., Mors, O., Demur, A. B., Als, T. D., Nordentoft, M., Børglum, A., Mortensen, P. B., Kennedy, J., Werge, T. M., Hougaard, D. M. & Christiansen, M., 1 Dec 2018, In: PLoS ONE. 13, 12, 14 p., e0208828.

    Research output: Contribution to journalJournal articleResearchpeer-review

    4 Citations (Scopus)
    67 Downloads (Pure)
  • Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

    Haney, J. R., CommonMind Consortium, PsychENCODE Consortium & iPSYCH-BROAD Working Group, 9 Feb 2018, In: Science. 359, 6376, p. 693-697 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

    360 Citations (Scopus)
  • Socio-demographic characteristics of adults with self-reported ADHD symptoms in a Danishpopulation of 12,415 blood donors

    Høffding, L. K. E., Nielsen, M. H., Didriksen, M., Schow, T., Werge, T., Nielsen, K. R., Erikstrup, C., Pedersen, O. B., Hjalgrim, H., Jepsen, J. R. M., Hansen, T. F., Banasik, K., Ullum, H. & Burgdorf, K., 20 Aug 2018, In: Journal of Psychiatry and Behavioral Sciences. 3

    Research output: Contribution to journalJournal articleResearchpeer-review

    7 Downloads (Pure)
  • Spatial fine-mapping for gene-by-environment effects identifies risk hot spots for schizophrenia

    Fan, C. C., McGrath, J. J., Appadurai, V., Buil, A., Gandal, M. J., Schork, A. J., Mortensen, P. B., Agerbo, E., Geschwind, S. A., Geschwind, D., Werge, T., Thompson, W. K. & Pedersen, C. B., 1 Dec 2018, In: Nature Communications. 9, 7 p., 5296.

    Research output: Contribution to journalJournal articleResearchpeer-review

    8 Citations (Scopus)
    27 Downloads (Pure)
  • The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods

    Thornton, L. M., Munn-Chernoff, M. A., Baker, J. H., Juréus, A., Parker, R., Henders, A. K., Larsen, J. T., Petersen, L., Watson, H. J., Yilmaz, Z., Kirk, K. M., Gordon, S., Leppä, V. M., Martin, F. C., Whiteman, D. C., Olsen, C. M., Werge, T. M., Pedersen, N. L., Kaye, W., Bergen, A. W., & 26 othersHalmi, K. A., Strober, M., Kaplan, A. S., Woodside, D. B., Mitchell, J., Johnson, C. L., Brandt, H., Crawford, S., Horwood, L. J., Boden, J. M., Pearson, J. F., Duncan, L. E., Grove, J., Mattheisen, M., Jordan, J., Kennedy, M. A., Birgegård, A., Lichtenstein, P., Norring, C., Wade, T. D., Montgomery, G. W., Martin, N. G., Landén, M., Mortensen, P. B., Sullivan, P. F. & Bulik, C. M., 2018, In: Contemporary Clinical Trials. 74, p. 61-69 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

    17 Citations (Scopus)
  • The iPSYCH2012 case-cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders

    Pedersen, C. B., Bybjerg-Grauholm, J., Pedersen, M. G., Grove, J., Agerbo, E., Bækvad-Hansen, M., Poulsen, J. B., Hansen, C. S., McGrath, J. J., Als, T. D., Goldstein, J. I., Neale, B. M., Daly, M. J., Hougaard, D. M., Mors, O., Nordentoft, M., Børglum, A. D., Werge, T. & Mortensen, P. B., 1 Jan 2018, In: Molecular Psychiatry. 23, p. 6-14 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

    90 Citations (Scopus)
    96 Downloads (Pure)
  • 2017

    A mouse model of the schizophrenia-associated 1q21.1 microdeletion syndrome exhibits altered mesolimbic dopamine transmission

    Nielsen, J., Fejgin, K., Sotty, F., Nielsen, V., Mørk, A., Christoffersen, C. T., Yavich, L., Lauridsen, J. B., Clausen, D., Larsen, P. H., Egebjerg, J., Werge, T. M., Kallunki, P., Christensen, K. V. & Didriksen, M., 1 Nov 2017, In: Translational Psychiatry. 7, 12 p., 1261.

    Research output: Contribution to journalJournal articleResearchpeer-review

    21 Citations (Scopus)
    49 Downloads (Pure)
  • Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry

    Schork, A. J., iPSYCH-SSI-Broad Group & Werge, T. M., 2017, In: Scientific Reports. 7, 11 p., 11380.

    Research output: Contribution to journalJournal articleResearchpeer-review

    12 Citations (Scopus)
    41 Downloads (Pure)
  • CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

    Macé, A., Tuke, M. A., Deelen, P., Kristiansson, K., Mattsson, H., Nõukas, M., Sapkota, Y., Schick, U., Porcu, E., Rüeger, S., McDaid, A. F., Porteous, D., Winkler, T. W., Salvi, E., Shrine, N., Liu, X., Ang, W. Q., Zhang, W., Feitosa, M. F., Venturini, C., & 86 othersvan der Most, P. J., Rosengren, A., Wood, A. R., Beaumont, R. N., Jones, S. E., Ruth, K. S., Yaghootkar, H., Tyrrell, J., Havulinna, A. S., Boers, H., Mägi, R., Kriebel, J., Müller-Nurasyid, M., Perola, M., Nieminen, M., Lokki, M-L., Kähönen, M., Viikari, J. S., Geller, F., Lahti, J., Palotie, A., Koponen, P., Lundqvist, A., Rissanen, H., Bottinger, E. P., Afaq, S., Wojczynski, M. K., Lenzini, P., Nolte, I. M., Sparsø, T., Schupf, N., Christensen, K., Perls, T. T., Newman, A. B., Werge, T., Snieder, H., Spector, T. D., Chambers, J. C., Koskinen, S., Melbye, M., Raitakari, O. T., Lehtimäki, T., Tobin, M. D., Wain, L. V., Sinisalo, J., Peters, A., Meitinger, T., Martin, N. G., Wray, N. R., Montgomery, G. W., Medland, S. E., Swertz, M. A., Vartiainen, E., Borodulin, K., Männistö, S., Murray, A., Bochud, M., Jacquemont, S., Rivadeneira, F., Hansen, T. F., Oldehinkel, A. J., Mangino, M., Province, M. A., Deloukas, P., Kooner, J. S., Freathy, R. M., Pennell, C., Feenstra, B., Strachan, D. P., Lettre, G., Hirschhorn, J., Cusi, D., Heid, I. M., Hayward, C., Männik, K., Beckmann, J. S., Loos, R. J. F., Nyholt, D. R., Metspalu, A., Eriksson, J. G., Weedon, M. N., Salomaa, V., Franke, L., Reymond, A., Frayling, T. M. & Kutalik, Z., 1 Dec 2017, In: Nature Communications. 8, 11 p., 744.

    Research output: Contribution to journalJournal articleResearchpeer-review

    28 Citations (Scopus)
    24 Downloads (Pure)
  • Comorbidities to restless legs syndrome – results from the Danish blood donor study

    Didriksen, M., Hansen, T., Rigas, A., Allen, R., Burchell, B., Thørner, L., Nielsen, K., Di Angelantonio, E., Nielsen, M., Jennum, P., Werge, T., Erikstrup, C., Pedersen, O., Paarup, H., Hjalgrim, H., Bruun, M., Burgdorf, K., Sørensen, E. & Ullum, H., 2017, In: Sleep Medicine. 40, Supplement 1, p. E79 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

    Marshall, C. R., Howrigan, D. P., Merico, D., Thiruvahindrapuram, B., Wu, W., Greer, D. S., Antaki, D., Shetty, A., Holmans, P. A., Pinto, D., Gujral, M., Brandler, W. M., Malhotra, D., Wang, Z., Fuentes Fajarado, K. V., Maile, M. S., Ripke, S., Agartz, I., Albus, M., Alexander, M., & 34 othersAmin, F., Atkins, J., Bacanu, S. A., Belliveau, R. A., Bergen, S. E., Bertalan, M., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Bulik-Sullivan, B., Byerley, W., Cahn, W., Cai, G., Cairns, M. J., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Cheng, W., Hansen, M., Hansen, T., Olsen, L., Pers, T. H., Rasmussen, H. B., Werge, T., Scherer, S. W., Neale, B. M., Sebat, J. & CNV and Schizophrenia Working Groups of the Psychiatric Genomics Consortium, 2017, In: Nature Genetics. 49, 1, p. 27-35

    Research output: Contribution to journalJournal articleResearchpeer-review

    397 Citations (Scopus)
  • Differential DNA methylation at birth associated with mental disorder in individuals with 22q11.2 deletion syndrome

    Starnawska, A., Hansen, C. S., Sparsø, T., Mazin, W., Olsen, L., Bertalan, M., Buil, A., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Hougaard, D. M., Mortensen, P. B., Pedersen, C. B., Nyegaard, M., Werge, T. & Weinsheimer, S., 29 Aug 2017, In: Translational Psychiatry. 7, 11 p., e1221.

    Research output: Contribution to journalJournal articleResearchpeer-review

    10 Citations (Scopus)
    51 Downloads (Pure)
  • Evaluation of shared genetic susceptibility loci between autoimmune diseases and schizophrenia based on genome-wide association studies

    Hoeffding, L. K. E., Rosengren, A., Thygesen, J. H., Schmock, H., Werge, T. & Hansen, T., 2017, In: Nordic Journal of Psychiatry. 71, 1, p. 20-25 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

    5 Citations (Scopus)
  • Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations

    Milaneschi, Y., Lamers, F., Peyrot, W. J., Baune, B. T., Breen, G., Dehghan, A., Forstner, A. J., Grabe, H. J., Homuth, G., Kan, C., Lewis, C., Mullins, N., Nauck, M., Pistis, G., Preisig, M., Rivera, M., Rietschel, M., Streit, F., Strohmaier, J., Teumer, A., & 31 othersVan Der Auwera, S., Wray, N. R., Boomsma, D. I., Penninx, B. W. J. H., CHARGE InflammationWorking Group and the Major Depressive DisorderWorking Group of the Psychiatric Genomics Consortium, Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J., Agerbo, E., Air, T. M., Andlauer, T. F. M., Bacanu, S. A., Bakvad-Hansen, M., Beekman, A. T. F., Bigdeli, T. B., Binder, E. B., Blackwood, D. H. R., Bryois, J., Buttenschon, H. N., Bybjerg-Grauholm, J., Cai, N., Hansen, C. S., Hansen, T. F., Krogh, J., Pedersen, C. B., Pedersen, M. G., Nordentoft, M. & Werge, T., Dec 2017, In: JAMA Psychiatry. 74, 12, p. 1214-1225 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

    77 Citations (Scopus)
  • Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

    McLaughlin, R. L., Schijven, D., Van Rheenen, W., Van Eijk, K. R., O'Brien, M., Kahn, R. S., Ophoff, R. A., Goris, A., Bradley, D. G., Al-Chalabi, A., Van Den Berg, L. H., Luykx, J. J., Hardiman, O., Veldink, J. H., Shatunov, A., Dekker, A. M., Diekstra, F. P., Pulit, S. L., Van Der Spek, R. A. A., Van Doormaal, P. T. C., & 31 othersSproviero, W., Jones, A. R., Nicholson, G. A., Rowe, D. B., Pamphlett, R., Kiernan, M. C., Bauer, D., Kahlke, T., Williams, K., Eftimov, F., Fogh, I., Ticozzi, N., Lin, K., Millecamps, S., Salachas, F., Meininger, V., Carvalho, M. D., Pinto, S., Mora, J. S., Rojas-Garcyá, R., Polak, M., Chandran, S., Andersen, P. M., Pers, T. H., Hansen, M., Hansen, T., Li, T., Olsen, L., Rasmussen, H. B., Werge, T. & Project MinE GWAS Consortium & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2017, In: Nature Communications. 8, 14774.

    Research output: Contribution to journalJournal articleResearchpeer-review

    61 Citations (Scopus)
    56 Downloads (Pure)
  • Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

    Joshi, P. K., Pirastu, N., Kentistou, K. A., Fischer, K., Hofer, E., Schraut, K. E., Clark, D. W., Nutile, T., Barnes, C. L. K., Timmers, P. R. H. J., Shen, X., Gandin, I., McDaid, A. F., Hansen, T. F., Gordon, S. D., Giulianini, F., Boutin, T. S., Abdellaoui, A., Zhao, W., Medina-Gomez, C., & 34 othersBartz, T. M., Trompet, S., Lange, L. A., Raffield, L., van der Spek, A., Galesloot, T. E., Proitsi, P., Yanek, L. R., Bielak, L. F., Payton, A., Murgia, F., Concas, M. P., Biino, G., Tajuddin, S. M., Seppälä, I., Amin, N., Boerwinkle, E., Børglum, A. D., Campbell, A., Demerath, E. W., Demuth, I., Faul, J. D., Ford, I., Gialluisi, A., Gögele, M., Graff, M., Hingorani, A., Hottenga, J-J., Hougaard, D. M., Werge, T., Esko, T., Kutalik, Z., Wilson, J. F. & et al., 1 Dec 2017, In: Nature Communications. 8, 13 p., 910.

    Research output: Contribution to journalJournal articleResearchpeer-review

    61 Citations (Scopus)
    47 Downloads (Pure)
  • Identification of Gene Loci That Overlap Between Schizophrenia and Educational Attainment

    Le Hellard, S., Wang, Y., Witoelar, A., Zuber, V., Bettella, F., Hugdahl, K., Espeseth, T., Steen, V. M., Melle, I., Desikan, R., Schork, A. J., Thompson, W. K., Dale, A. M., Djurovic, S., Andreassen, O. A., Schizophrenia Working Group of the Psychiatric Genomics Consortium, Ripke, S., Neale, B. M., Corvin, A., Pers, T. H., & 11 othersAgerbo, E., Demontis, D., Hansen, T., Hollegaard, M. V., Hougaard, D. M., Mors, O., Børglum, A. D., Werge, T., Daly, M. J., Sullivan, P. F. & O'Donovan, M. C., 2017, In: Schizophrenia Bulletin. 43, 3, p. 654-664

    Research output: Contribution to journalJournal articleResearchpeer-review

    30 Citations (Scopus)
  • Is an Early Age at Illness Onset in Schizophrenia Associated With Increased Genetic Susceptibility?

    Hilker, R., Helenius, D., Fagerlund, B., Skytthe, A., Christensen, K., Werge, T. M., Nordentoft, M. & Glenthøj, B., 2017, In: EBioMedicine. 18, p. 320-326

    Research output: Contribution to journalJournal articleResearchpeer-review

    8 Citations (Scopus)
    48 Downloads (Pure)
  • Lessons to be learned from 22q2.11 syndromes: reply

    Hoeffding, L. K., Pedersen, C. B. & Werge, T., Jul 2017, In: JAMA Psychiatry. 74, 7, p. 757-758 2 p.

    Research output: Contribution to journalComment/debateResearch

  • Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism

    Sapkota, Y., Steinthorsdottir, V., Morris, A. P., Fassbender, A., Rahmioglu, N., De Vivo, I., Buring, J. E., Zhang, F., Edwards, T. L., Jones, S., Dorien, O., Peterse, D., Rexrode, K. M., Ridker, P. M., Schork, A. J., MacGregor, S., Martin, N. G., Becker, C. M., Adachi, S., Yoshihara, K., & 23 othersEnomoto, T., Takahashi, A., Kamatani, Y., Matsuda, K., Kubo, M., Thorleifsson, G., Geirsson, R. T., Thorsteinsdottir, U., Wallace, L. M., Werge, T. M., Thompson, W. K., Yang, J., Velez Edwards, DI. R., Nyegaard, M., Low, S. K., Zondervan, K. T., Missmer, S. A., D'Hooghe, T., Montgomery, G. W., Chasman, D. I., Stefansson, K., Tung, J. Y. & Nyholt, D. R., 24 May 2017, In: Nature Communications. 8, 12 p., 15539.

    Research output: Contribution to journalJournal articleResearchpeer-review

    109 Citations (Scopus)
    71 Downloads (Pure)
  • Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia

    Anney, R. J. L., Ripke, S., Anttila, V., Grove, J., Holmans, P., Huang, H., Klei, L., Lee, P. H., Medland, S. E., Neale, B., Robinson, E., Weiss, L. A., Zwaigenbaum, L., Yu, T. W., Wittemeyer, K., Willsey, A. J., Wijsman, E. M., Werge, T., Wassink, T. H., Waltes, R., & 143 othersWalsh, C. A., Wallace, S., Vorstman, J. A. S., Vieland, V. J., Vicente, A. M., Vanengeland, H., Tsang, K., Thompson, A. P., Szatmari, P., Svantesson, O., Steinberg, S., Stefansson, K., Stefansson, H., State, M. W., Soorya, L., Silagadze, T., Scherer, S. W., Schellenberg, G. D., Sandin, S., Sanders, S. J., Saemundsen, E., Rouleau, G. A., Rogé, B., Roeder, K., Roberts, W., Reichert, J., Reichenberg, A., Rehnström, K., Regan, R., Poustka, F., Poultney, C. S., Piven, J., Pinto, D., Pericak-Vance, M. A., Pejovic-Milovancevic, M., Pedersen, M. G., Pedersen, C. B., Paterson, A. D., Parr, J. R., Pagnamenta, A. T., Oliveira, G., Nurnberger, J. I., Nordentoft, M., Murtha, M. T., Mouga, S., Mortensen, P. B., Mors, O., Morrow, E. M., Moreno-De-Luca, D., Monaco, A. P., Minshew, N., Merikangas, A., McMahon, W. M., McGrew, S. G., Mattheisen, M., Martsenkovsky, I., Martin, D. M., Mane, S. M., Magnusson, P., Magalhaes, T., Maestrini, E., Lowe, J. K., Lord, C., Levitt, P., Martin, C. L., Ledbetter, D. H., Leboyer, M., Lecouteur, A. S., Ladd-Acosta, C., Kolevzon, A., Klauck, S. M., Jacob, S., Iliadou, B., Hultman, C. M., Hougaard, D. M., Hertz-Picciotto, I., Hendren, R., Hansen, C. S., Haines, J. L., Guter, S. J., Grice, D. E., Green, J. M., Green, A., Goldberg, A. P., Gillberg, C., Gilbert, J., Gallagher, L., Freitag, C. M., Fombonne, E., Folstein, S. E., Fernandez, B., Fallin, M. D., Ercan-Sencicek, A. G., Ennis, S., Duque, F., Duketis, E., Delorme, R., Derubeis, S., Dejonge, M. V., Dawson, G., Cuccaro, M. L., Correia, C. T., Conroy, J., Conceição, I. C., Chiocchetti, A. G., Celestino-Soper, P. B. S., Casey, J., Cantor, R. M., Café, C., Bybjerg-Grauholm, J., Brennan, S., Bourgeron, T., Bolton, P. F., Bölte, S., Bolshakova, N., Betancur, C., Bernier, R., Beaudet, A. L., Battaglia, A., Bal, V. H., Baird, G., Bailey, A. J., Bækvad-Hansen, M., Bader, J. S., Bacchelli, E., Anagnostou, E., Amaral, D., Almeida, J., Børglum, A. D., Buxbaum, J. D., Chakravarti, A., Cook, E. H., Coon, H., Geschwind, D. H., Gill, M., Hakonarson, H., Hallmayer, J., Palotie, A., Santangelo, S., Sutcliffe, J. S., Arking, D. E., Devlin, B. & Daly, M. J., 22 May 2017, In: Molecular Autism. 8, 17 p., 21.

    Research output: Contribution to journalJournal articleResearchpeer-review

    54 Citations (Scopus)
    128 Downloads (Pure)
  • Nomenclature for alleles of the human carboxylesterase 1 gene

    INDICES Consortium, 1 Jan 2017, In: Pharmacogenetics and Genomics. 27, 2, p. 78-80 3 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

    4 Citations (Scopus)
  • Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: A study in male mice

    Didriksen, M., Fejgin, K., Nilsson, S. R. O., Birknow, M. R., Grayton, H. M., Larsen, P. H., Lauridsen, J. B., Nielsen, V., Celada, P., Santana, N., Kallunki, P., Christensen, K. V., Werge, T. M., Stensbøl, T. B., Egebjerg, J., Gastambide, F., Artigas, F., Bastlund, J. F. & Nielsen, J., 2017, In: Journal of Psychiatry and Neuroscience. 42, 1, p. 48-58 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

    22 Citations (Scopus)
  • Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

    Weiner, D. J., Wigdor, E. M., Ripke, S., Walters, R. K., Kosmicki, J. A., Grove, J., Samocha, K. E., Goldstein, J. I., Okbay, A., Bybjerg-Grauholm, J., Werge, T., Hougaard, D. M., Taylor, J., Skuse, D., Devlin, B., Anney, R., Sanders, S. J., Bishop, S., Mortensen, P. B., Børglum, A. D., & 32 othersSmith, G. D., Daly, M. J., Robinson, E. B., Bækvad-Hansen, M., Dumont, A., Hansen, C., Hansen, T. F., Howrigan, D., Mattheisen, M., Moran, J., Mors, O., Nordentoft, M., Nørgaard-Pedersen, B., Poterba, T., Poulsen, J., Stevens, C., Anttila, V., Holmans, P., Huang, H., Klei, L., Lee, P. H., Medland, S. E., Neale, B., Weiss, L. A., Zwaigenbaum, L., Yu, T. W., Wittemeyer, K., Willsey, A. J., Wijsman, E. M., Wassink, T. H., Psychiatric Genomics Consortium Autism Group & iPSYCH-Broad Autism Group, Jul 2017, In: Nature Genetics. 49, 7, p. 978-985 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

    178 Citations (Scopus)
  • Prevalence of restless legs syndrome and associated factors in an otherwise healthy population: results from the Danish Blood Donor Study

    Didriksen, M., Rigas, A. S., Allen, R. P., Burchell, B. J., Di Angelantonio, E., Nielsen, M. H., Jennum, P., Werge, T., Erikstrup, C., Pedersen, O. B., Bruun, M. T., Burgdorf, K. S., Sørensen, E. & Ullum, H., 1 Aug 2017, In: Sleep Medicine. 36, p. 55-61 7 p.

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    23 Citations (Scopus)
  • Quetiapine extended release versus aripiprazole in children and adolescents with first-episode psychosis: the multicentre, double-blind, randomised tolerability and efficacy of antipsychotics (TEA) trial

    Pagsberg, A. K., Jeppesen, P., Klauber, D. G., Jensen, K. G., Ruda, D., Stentebjerg-Olesen, M., Jantzen, P., Rasmussen, S., Saldeen, E. A-S., Lauritsen, M-B. G., Bilenberg, N., Stenstrom, A. D., Nyvang, L., Madsen, S., Werge, T. M., Lange, T., Gluud, C., Skoog, M., Winkel, P., Jepsen, J. R. M., & 3 othersFagerlund, B., Correll, C. U. & Fink-Jensen, A., Aug 2017, In: The Lancet Psychiatry. 4, 8, p. 605-618

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    24 Citations (Scopus)
  • Risk of psychiatric disorders among individuals with the 22q11.2 deletion or duplication: A Danish nationwide, register-based study

    Hoeffding, L. K., Trabjerg, B. B., Olsen, L., Mazin, W., Sparsø, T., Vangkilde, A., Mortensen, P. B., Pedersen, C. B. & Werge, T., 1 Mar 2017, In: JAMA Psychiatry. 74, 3, p. 282-290 9 p.

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    50 Citations (Scopus)
  • Severe Parkinsonism and Creatine Kinase Increase After Low-Dose Aripiprazole Treatment in a Patient of African Descent

    Jørgensen, A., Thorleifsson, A., Jimenez-Solem, E., Werge, T. & Rasmussen, H. B., 1 Oct 2017, In: Journal of Clinical Psychopharmacology. 37, 5, p. 630-631

    Research output: Contribution to journalLetterpeer-review

    3 Citations (Scopus)
  • The catechol-O-methyltransferase (COMT) Val158Met genotype modulates working memory-related dorsolateral prefrontal response and performance in bipolar disorder

    Miskowiak, K. W., Kjærstad, H. L., Støttrup, M. M., Svendsen, A. M., Demant, K. M., Hoeffding, L. K., Werge, T. M., Burdick, K. E., Domschke, K., Carvalho, A. F., Vieta, E., Vinberg, M., Kessing, L. V., Siebner, H. R. & Macoveanu, J., May 2017, In: Bipolar Disorders. 19, 3, p. 214-224 11 p.

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    13 Citations (Scopus)
  • 2016

    15q13.3 homozygous knockout mouse model display epilepsy-, autism- and schizophrenia-related phenotypes

    Forsingdal, A., Fejgin, K., Nielsen, V., Werge, T. & Nielsen, J., 2016, In: Translational Psychiatry. 6, 7, p. 1-9 9 p., e860.

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    64 Downloads (Pure)
  • An epigenetic clock for gestational age at birth based on blood methylation data

    Knight, A. K., Craig, J. M., Theda, C., Bækvad-Hansen, M., Bybjerg-Grauholm, J., Hansen, C. S., Hollegaard, M. V., Hougaard, D. M., Mortensen, P. B., Weinsheimer, S. M., Werge, T. M., Brennan, P. A., Cubells, J. F., Newport, D. J., Stowe, Z. N., Cheong, J. L. Y., Dalach, P., Doyle, L. W., Loke, Y. J., Baccarelli, A. A., & 27 othersJust, A. C., Wright, R. O., Téllez-rojo, M. M., Svensson, K., Trevisi, L., Kennedy, E. M., Binder, E. B., Iurato, S., Czamara, D., Räikkönen, K., Lahti, J. M. T., Pesonen, A., Kajantie, E., Villa, P. M., Laivuori, H., Hämäläinen, E., Park, H. J., Bailey, L. B., Parets, S. E., Kilaru, V., Menon, R., Horvath, S., Bush, N. R., Lewinn, K. Z., Tylavsky, F. A., Conneely, K. N. & Smith, A. K., 7 Oct 2016, In: Genome Biology (Online Edition). 17, 11 p., 206.

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    80 Citations (Scopus)
  • Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort

    Bertelsen, B., Stefánsson, H., Riff Jensen, L., Melchior, L., Debes, N. M., Groth, C., Skov, L., Werge, T., Karagiannidis, I., Tarnok, Z., Barta, C., Nagy, P., Farkas, L., Brøndum-Nielsen, K., Rizzo, R., Gulisano, M., Rujescu, D., Kiemeney, L. A., Tosato, S., Nawaz, M. S., & 14 othersIngason, A., Unnsteinsdottir, U., Steinberg, S., Ludvigsson, P., Stefansson, K., Kuss, A. W., Paschou, P., Cath, D., Hoekstra, P. J., Müller-Vahl, K., Stuhrmann, M., Silahtaroglu, A., Pfundt, R. & Tümer, Z., 1 Mar 2016, In: Biological Psychiatry. 79, 5, p. 383–391 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

    23 Citations (Scopus)
  • Associations between social cognition, skills, and function and subclinical negative and positive symptoms in 22q11.2 deletion syndrome

    Vangkilde, A., Jepsen, J. M. R., Schmock, H., Olesen, C., Arnarsdóttir, S., Baaré, W. F. C., Plessen, K. J., Didriksen, M., Siebner, H. R., Werge, T. & Olsen, L., 16 Nov 2016, In: Journal of Neurodevelopmental Disorders. 8, 13 p., 42.

    Research output: Contribution to journalJournal articleResearchpeer-review

    16 Citations (Scopus)
  • Digital questionnaire platform in the Danish Blood Donor Study

    Burgdorf, K. S., Felsted, N., Mikkelsen, S., Nielsen, M. H., Thørner, L. W., Pedersen, O. B., Sørensen, E., Nielsen, K. R., Bruun, M. T., Werge, T., Erikstrup, C., Hansen, T. & Ullum, H., 1 Oct 2016, In: Computer Methods and Programs in Biomedicine. 135, p. 101-104 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

    16 Citations (Scopus)
  • Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

    Holland, D., Wang, Y., Thompson, W. K., Schork, A. J., Chen, C-H., Lo, M-T., Witoelar, A., Werge, T., O'Donovan, M. C., Andreassen, O. A., Dale, A. M. & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2016, In: Frontiers in Genetics. 7, 13 p., 15.

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    18 Citations (Scopus)
  • Evidence for Genetic Overlap Between Schizophrenia and Age at First Birth in Women

    Schizophrenia Working Group of the Psychiatric Genomics Consortium, LifeLines Cohort Study, TwinsUK & Werge, T., May 2016, In: J A M A Psychiatry. 73, 5, p. 497-505 9 p.

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    23 Citations (Scopus)
  • Genetic Markers of Human Evolution Are Enriched in Schizophrenia

    Srinivasan, S., Bettella, F., Mattingsdal, M., Wang, Y., Witoelar, A., Schork, A. J., Thompson, W. K., Zuber, V., Winsvold, B. S., Zwart, J-A., Collier, D. A., Desikan, R. S., Melle, I., Werge, T., Dale, A. M., Djurovic, S., Andreassen, O. A. & Schizophrenia Working Group of the Psychiatric Genomics Consortium, The International Headache Genetics Consortium, 15 Aug 2016, In: Biological Psychiatry. 80, 4, p. 284-92 9 p.

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    49 Citations (Scopus)
  • Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population

    Robinson, E. B., St Pourcain, B., Anttila, V., Kosmicki, J. A., Bulik-Sullivan, B., Grove, J., Maller, J., Samocha, K. E., Sanders, J-S. F., Ripke, S., Martin, J., Hollegaard, M. V., Werge, T., Hougaard, D. M., Neale, B. M., Evans, D. M., Skuse, D., Mortensen, P. B., Børglum, A. D., Ronald, A., & 3 othersSmith, G. D., Daly, M. J. & iPSYCH-SSI-Broad Autism Group, 1 May 2016, In: Nature Genetics. 48, 5, p. 552-5 4 p.

    Research output: Contribution to journalLetterpeer-review

    195 Citations (Scopus)
  • Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness

    Bigdeli, T. B., Ripke, S., Bacanu, S-A., Lee, S. H., Wray, N. R., Gejman, P. V., Rietschel, M., Cichon, S., St Clair, D., Corvin, A., Kirov, G., McQuillin, A., Gurling, H., Rujescu, D., Andreassen, O. A., Werge, T., Blackwood, D. H. R., Pato, C. N., Pato, M. T., Malhotra, A. K., & 4 othersO'Donovan, M. C., Kendler, K. S., Fanous, A. H. & and Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2016, In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 171, 2, p. 276-289 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

    22 Citations (Scopus)
  • High loading of polygenic risk in cases with chronic schizophrenia

    Meier, S. M., Agerbo, E., Maier, R., Pedersen, C. B., Lang, M., Grove, J., Hollegaard, M. V., Demontis, D., Trabjerg, B. B., Hjorthøj, C., Ripke, S., Degenhardt, F., Nöthen, M. M., Rujescu, D., Maier, W., Werge, T., Mors, O., Hougaard, D. M., Børglum, A. D., Wray, N. R., & 5 othersRietschel, M., Nordentoft, M., Mortensen, P. B., Mattheisen, M. & MooDS SCZ Consortium, 1 Jul 2016, In: Molecular Psychiatry. 21, p. 969-974

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    33 Citations (Scopus)
  • High-Quality Exome Sequencing of Whole-Genome Amplified Neonatal Dried Blood Spot DNA

    Poulsen, J. B., Lescai, F., Grove, J., Bækvad-Hansen, M., Christiansen, M., Hagen, C. M., Maller, J., Stevens, C., Li, S., Li, Q., Sun, J., Wang, J., Nordentoft, M., Werge, T. M., Mortensen, P. B., Børglum, A. D., Daly, M., Hougaard, D. M., Bybjerg-Grauholm, J. & Hollegaard, M. V., Apr 2016, In: P L o S One. 11, 4, 13 p., e0153253.

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    20 Citations (Scopus)
    69 Downloads (Pure)
  • Identification of rare high-risk copy number variants affecting the dopamine transporter gene in mental disorders

    Hoeffding, L. K. E., Duong, L. T. T., Ingason, A., Rosengren, A., Sorbanski, E., Witt, S. H., Djurovic, S., Andreassen, O. A., Hansen, T., Werge, T. & Rasmussen, H. B., 18 May 2016, In: Nordic Journal of Psychiatry. 70, 4, p. 276-279 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

    2 Citations (Scopus)
  • Investigation of SNP rs2060546 Immediately Upstream to NTN4 in a Danish Gilles de la Tourette Syndrome Cohort

    Padmanabhuni, S. S., Houssari, R., Esserlind, A-L., Olesen, J., Werge, T. M., Hansen, T. F., Bertelsen, B., Tsetsos, F., Paschou, P. & Tümer, Z., Nov 2016, In: Frontiers in Neuroscience. 10, 7 p., 531.

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    3 Citations (Scopus)
  • Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS

    Wang, Y., Thompson, W. K., Schork, A. J., Holland, D., Chen, C-H., Bettella, F., Desikan, R. S., Li, W., Witoelar, A., Zuber, V., Devor, A., Nöthen, M. M., Rietschel, M., Chen, Q., Werge, T., Cichon, S., Weinberger, D. R., Djurovic, S., O'Donovan, M. C., Visscher, P. M., & 2 othersAndreassen, O. A. & Dale, A. M., 2016, In: P L o S Genetics. 12, 1, 22 p., e1005803.

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    20 Citations (Scopus)
  • Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

    Gormley, P., Anttila, V., Winsvold, B. S., Palta, P., Esko, T., Pers, T. H., Farh, K-H., Cuenca-Leon, E., Muona, M., Furlotte, N. A., Kurth, T., Ingason, A., McMahon, G., Ligthart, L., Terwindt, G. M., Kallela, M., Freilinger, T. M., Ran, C., Gordon, S. G., Stam, A. H., & 31 othersSteinberg, S., Borck, G., Koiranen, M., Quaye, L., Adams, H. H. H., Lehtimäki, T., Sarin, A-P., Wedenoja, J., Hinds, D. A., Buring, J. E., Schürks, M., Ridker, P. M., Hrafnsdottir, M. G., Stefansson, H., Ring, S. M., Hottenga, J-J., Penninx, B. W. J. H., Färkkilä, M., Artto, V., Kaunisto, M., Vepsäläinen, S., Malik, R., Heath, A. C., Madden, P. A. F., Martin, N. G., Montgomery, G. W., Christensen, A. F., Hansen, T. F., Werge, T., Olesen, J. & International Headache Genetics Consortium, 1 Aug 2016, In: Nature Genetics. 48, 8, p. 856-66 11 p.

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    241 Citations (Scopus)
  • No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study

    Johnson, E. C., Bjelland, D. W., Howrigan, D. P., Abdellaoui, A., Breen, G., Borglum, A. D., Cichon, S., Degenhardt, F., Forstner, A. J., Frank, J., Genovese, G., Heilmann-Heimbach, S., Herms, S., Hoffman, P., Maier, W., Mattheisen, M., Morris, D. W., Mowry, B. J., Müller-Mhysok, B., Neale, B. M., & 297 othersNenadic, I., Nöthen, M. M., O’Dushlaine, C., Rietschel, M., Ruderfer, D. M., Rujescu, D., Schulze, T. G., Simonson, M. A., Stahl, E. A., Strohmaier, J., Witt, S. H., Ripke, S., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K-H., Holmans, P. A., Lee, P. H., Bulik-Sullivan, B., Collier, D. A., Huang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., Bacanu, S-A., Begemann, M., Belliveau, R. A., Bene, J., Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Byerley, W. F., Cahn, W., Cai, G., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Chan, R. C. K., Chen, R. Y. L., Chen, E. Y. H., Cheng, W., Cheung, E. F. C., Chong, S. A., Robert Cloninger, C., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Crowley, J. J., Curtis, D., Davidson, M., Davis, K. L., Del-Favero, J., Demontis, D., Dikeos, D., Dinan, T., Djurovic, S., Donohoe, G., Drapeau, E., Duan, J., Dudbridge, F., Durmishi, N., Eichhammer, P., Eriksson, J., Escott-Price, V., Essioux, L., Fanous, A. H., Farrell, M. S., Franke, L., Freedman, R., Freimer, N. B., Friedl, M., Friedman, J. I., Fromer, M., Georgieva, L., Giegling, I., Giusti-Rodríguez, P., Godard, S., Goldstein, J. I., Golimbet, V., Gopal, S., Gratten, J., de Haan, L., Hammer, C., Hamshere, M. L., Hansen, M., Hansen, T., Haroutunian, V., Hartmann, A. M., Henskens, F. A., Hirschhorn, J. N., Hoffmann, P., Hofman, A., Hollegaard, M. V., Hougaard, D. M., Ikeda, M., Joa, I., Julià, A., Kahn, R. S., Kalaydjieva, L., Karachanak-Yankova, S., Karjalainen, J., Kavanagh, D., Kennedy, J. L., Khrunin, A., Kim, Y., Klovins, J., Knowles, J. A., Konte, B., Kucinskas, V., Kucinskiene, Z. A., Kuzelova-Ptackova, H., Kähler, A. K., Laurent, C., Chee Keong, J. L., Hong Lee, S., Legge, S. E., Lerer, B., Li, M., Li, T., Liang, K-Y., Lieberman, J., Limborska, S., Loughland, C. M., Lubinski, J., Lönnqvist, J., Macek, M., Magnusson, P. K. E., Maher, B. S., Mallet, J., Marsal, S., Mattingsdal, M., McCarley, R. W., McDonald, C., McIntosh, A. M., Meier, S. M., Meijer, C. J., Melegh, B., Melle, I., Mesholam-Gately, R. I., Metspalu, A., Michie, P. T., Milani, L., Milanova, V., Mokrab, Y., Morris, D. W., Mors, O., Murphy, K. C., Murray, R. M., Myin-Germeys, I., Müller-Myhsok, B., Nelis, M., Nertney, D. A., Nestadt, G., Nicodemus, K. K., Nikitina-Zake, L., Nisenbaum, L., Nordin, A., O'Callaghan, E., O'Dushlaine, C. T., Anthony O'Neill, F., Oh, S. Y., Olincy, A., Olsen, L., van Os, J., Pantelis, C., Papadimitriou, G. N., Papiol, S., Parkhomenko, E., Pato, M. T., Paunio, T., Pejovic-Milovancevic, M., Perkins, D. O., Pietiläinen, O., Pimm, J., Pocklington, A. J., Powell, J., Price, A. L., Pulver, A. E., Purcell, S. M., Quested, D., Rasmussen, H. B., Reichenberg, A., Reimers, M. A., Richards, A. L., Roffman, J. L., Roussos, P., Salomaa, V., Sanders, A. R., Schall, U., Schubert, C. R., Schwab, S. G., Scolnick, E. M., Scott, R. J., Seidman, L. J., Shi, J., Sigurdsson, E., Silagadze, T., Silverman, J. M., Sim, K., Slominsky, P., Smoller, J. W., So, H. C., Spencer, C. C. A., Stahl, E. A., Stefansson, H., Steinberg, S., Stogmann, E., Straub, R. E., Strengman, E., Scott Stroup, T., Subramaniam, M., Suvisaari, J., Svrakic, D. M., Szatkiewicz, J. P., Söderman, E., Thirumalai, S., Toncheva, D., Tosato, S., Veijola, J., Waddington, J., Walsh, D., Wang, D., Wang, Q., Webb, B. T., Weiser, M., Wildenauer, D. B., Williams, N. M., Watts-Williams, S. J., Wolen, A. R., Wong, E. H. M., Wormley, B. K., Xi, H. S., Zai, C. C., Zheng, X., Zimprich, F., Wray, N. R., Stefansson, K., Visscher, P. M., Adolfsson, R., Andreassen, O. A., Blackwood, D. H. R., Bramon, E., Buxbaum, J. D., Børglum, A. D., Darvasi, A., Domenici, E., Ehrenreich, H., Esko, T., Gejman, P. V., Gill, M., Gurling, H., Hultman, C. M., Iwata, N., Jablensky, A. V., Jönsson, E. G., Kendler, K. S., Kirov, G., Knight, J., Lencz, T., Levinson, D. F., Li, Q. S., Liu, J., Malhotra, A. K., McCarroll, S. A., McQuillin, A., Moran, J. L., Mortensen, P. B., Mowry, B. J., Nöthen, M. M., Ophoff, R. A., Owen, M. J., Palotie, A., Pato, C. N., Petryshen, T. L., Posthuma, D., Riley, B. P., Sham, P-C., Sklar, P., St Clair, D., Weinberger, D. R., Wendland, J. R., Werge, T., Daly, M. J., O'Donovan, M. C., Sullivan, P. F. & Keller, M. C., 1 Oct 2016, In: PLOS Genetics. 12, 10, 20 p., e1006343.

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    9 Citations (Scopus)
    82 Downloads (Pure)
  • Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders

    Isles, A. R., Ingason, A., Lowther, C., Walters, J. T. R., Gawlick, M., Stöber, G., Rees, E., Martin, J., Little, R. B., Potter, H., Georgieva, L., Pizzo, L., Ozaki, N., Aleksic, B., Kushima, I., Ikeda, M., Iwata, N., Levinson, D. F., Gejman, P. V., Shi, J., & 20 othersSanders, A. R., Duan, J., Willis, J., Sisodiya, S. M., Costain, G., Werge, T. M., Degenhardt, F., Giegling, I., Rujescu, D., Hreidarsson, S. J., Saemundsen, E., Ahn, J. W., Ogilvie, C. M., Girirajan, S. D., Stefansson, H., Stefansson, K., O'Donovan, M. C., Owen, M. J., Bassett, A. & Kirov, G., May 2016, In: P L o S Genetics. 12, 5, e1005993.

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    32 Citations (Scopus)