Berthe Marie Willumsen

2018

Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2

Højfeldt, J. W., Laugesen, A., Willumsen, B. M., Damhofer, H., Hedehus, L., Tvardovskiy, A., Mohammad, F., Jensen, O. N. & Helin, K., 1 Mar 2018, In: Nature Structural & Molecular Biology. 25, p. 225-232 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

61 Citations (Scopus)

2012

Identification of a c-Jun N-terminal kinase-2-dependent signal amplification cascade that regulates c-Myc levels in ras transformation

Mathiasen, D. P., Egebjerg, C., Andersen, S. H., Rafn, B., Puustinen, P., Khanna, A., Daugaard, M., Valo, E., Tuomela, S., Bøttzauw, T., Nielsen, C. T. F., Willumsen, B. M., Hautaniemi, S., Lahesmaa, R., Westermarck, J., Jäättelä, M. & Kallunki, T., 19 Jan 2012, In: Oncogene. 31, p. 390-401 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

33 Citations (Scopus)

2011

PRIMA-1Met/APR-246 induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53

Zandi, R., Selivanova, G., Christensen, C. L., Gerds, T. A., Willumsen, B. M. & Poulsen, H. S., 1 May 2011, In: Clinical Cancer Research. 17, 9, p. 2830-2841 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

78 Citations (Scopus)

2009

Differential effects of EGFR ligands on endocytic sorting of the receptor

Roepstorff, K., Grandal, M. V., Henriksen, L., Knudsen, S. L. J., Lerdrup, M., Grøvdal, L., Willumsen, B. M. & van Deurs, B., 2009, In: Traffic - International Journal of Intracellular Transport. 10, 8, p. 1115-27 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

211 Citations (Scopus)

2007

EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes.

Grandal, M. V., Zandi, R., Pedersen, M. W., Willumsen, B. M., van Deurs, B. & Poulsen, H. S., 2007, In: Carcinogenesis. 28, 7, p. 1408-17 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

94 Citations (Scopus)

2005

Elk3 from hamster--a ternary complex factor with strong transcriptional repressor activity

Hjortoe, G. M., Weilguny, D. & Willumsen, B. M., Jan 2005, In: D N A and Cell Biology. 24, 1, p. 35-42 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

High-density growth arrest in Ras-transformed cells: low Cdk kinase activities in spite of absence of p27^Kip Cdk-complexes

Groth, A. & Willumsen, B. M., 2005, In: Cellular Signalling. 17, 9, p. 1063-1073

Research output: Contribution to journal › Journal article › Research › peer-review

8 Citations (Scopus)

2003

C-terminal sequences in R-Ras are involved in integrin regulation and in plasma membrane microdomain distribution

Hansen, M., Prior, I. A., Hughes, P. E., Oertli, B., Chou, F. L., Willumsen, B. M., Hancock, J. F. & Ginsberg, M. H., 2003, In: Biochemical and Biophysical Research Communications. 311, p. 829-838

Research output: Contribution to journal › Journal article › Research › peer-review

24 Citations (Scopus)

2002

Rho family GTP binding proteins are involved in the regulatory volume decrease process in NIH3T3 mouse fibroblasts.

Pedersen, S. F., Beisner, K. H., Willumsen, B. M., Lambert, I. H. & Hoffmann, E. K., 2002, In: Journal of Physiology. 541, Pt 3, p. 779-96 17 p.

Research output: Contribution to journal › Journal article › Research › peer-review

68 Citations (Scopus)

R-Ras C-terminal sequences are sufficient to confer R-Ras specificity to H-Ras

Hansen, M., Rusyn, E. V., Hughes, P. E., Ginsberg, M. H., Cox, A. D. & Willumsen, B. M., 2002, In: Oncogene. 21, p. 4448-4461

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

Suppression of integrin activation by activated Ras or Raf does not correlate with bulk activation of ERK MAP kinase

Hughes, P. E., Oertli, B., Hansen, M., Chou, F. L., Willumsen, B. M. & Ginsberg, M. H., 2002, In: Molecular Biology of the Cell. 13, p. 2256-2265

Research output: Contribution to journal › Journal article › Research › peer-review

39 Citations (Scopus)

2001

Sensitivity of wild type and mutant ras alleles to Ras specific exchange factors: Identification of factor specific requirements

Nielsen, K. H., Gredsted, L., Broach, J. R. & Willumsen, B. M., 2001, In: Oncogene. 20, p. 2091-2100

Research output: Contribution to journal › Journal article › Research › peer-review

1998

Rac and Cdc42 are potent stimulators of E2F-dependent transcription capable of promoting retinoblastoma susceptibility gene product hyperphosphorylation

Gjørup, O., Lukas, J., Bartek, J. & Willumsen, B. M., 1998, In: Journal of Biological Chemistry. 273, p. 18812-18818

Research output: Contribution to journal › Journal article › Research › peer-review

65 Citations (Scopus)

1997

The Ras-specific exhange factors mouse Sos1 (mSos1) and mSos2 are regulated differently: mSos2 contains ubiquitination signals absent in mSos1

Nielsen, K., Papageorge, A. G., Vass, W. C., Willumsen, B. M. & Lowy, D. R., 1997, In: Molecular and Cellular Biology. Vol. 17, p. 7132-7138

Research output: Contribution to journal › Journal article › Research › peer-review

1996

Novel determinants of H-Ras plasma membrane localization and transformation.

Willumsen, B. M., Cox, A. D., Solski, P. A., Der, C. J. & Buss, J. E., 1996, In: Oncogene. 13, 9, p. 1901-9 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

83 Citations (Scopus)

Rasp21 sequences opposite the nucleotide binding pocket are required for GRF-mediated nucleotide release.

Leonardsen, L., DeClue, J. E., Lybaek, H., Lowy, D. R. & Willumsen, B. M., 1996, In: Oncogene. 13, 10, p. 2177-87 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

17 Citations (Scopus)

1995

Analysis of Ras acylation sites: Mutagenesis and Transfection

Willumsen, B. M., 1995, In Methods in Enzymology, Vol 250. New York: Academic Press, p. 269-284

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

10 Citations (Scopus)

Different structural requirements within the switch II region of the RAS protein for interactions with specific downstream targets

Moodie, S. A., Paris, M., Villafranca, E., Kirchmeier, P., Willumsen, B. M. & Wolfman, A., 1995, In: Oncogene. 11, p. 447-454

Research output: Contribution to journal › Journal article › Research › peer-review

59 Citations (Scopus)

Kinetics of Expression of inducible ß-Galactosidase in murine Fibroblasts: High initial rate compared to steady state expression

Jacobsen, K. & Willumsen, B. M., 1995, In: Journal of Molecular Biology. 252, p. 289-295

Research output: Contribution to journal › Journal article › Research › peer-review

Rational cancer therapy

Lowy, D. R. & Willumsen, B. M., 1995, In: Nature Medicine. Vol 1, No 8, p. 747-748

Research output: Contribution to journal › Letter

9 Citations (Scopus)

Two distinct regions of Ras participate in functional interaction with GDP-GTP exchangers

Segal, M., Marbach, I., Willumsen, B. M. & Levitzki, A., 1995, In: FEBS Journal. 228, p. 96-101

Research output: Contribution to journal › Journal article › Research › peer-review

21 Citations (Scopus)

1993

Complexes of Ras GTP with Raf-1 and nitrogen-activated protein kinase kinase

Moodie, S. A., Willumsen, B. M., Weber, M. J. & Wolfman, A., 1993, In: Kexue (Shanghai). Vol. 260, p. 1658-1661

Research output: Contribution to journal › Journal article › Research › peer-review

Function and regulation of Ras

Lowy, D. R. & Willumsen, B. M., 1993, In: Annual Review of Biochemistry. Vol. 62, p. 851-891

Research output: Contribution to journal › Review

1096 Citations (Scopus)

Residues crucial for Ras interaction with GDP-GTP exchangers

Segal, M., Willumsen, B. M. & Levitzki, A., 1993, In: Proceedings of the National Academy of Science of the United States of America. 90, p. 5564-5568

Research output: Contribution to journal › Journal article › Research › peer-review

34 Citations (Scopus)

The Ras transforming protein

Willumsen, B. M., 1993, Copenhagen: Academic Press. 124 p.

Research output: Book/Report › Doctoral thesis

1992

Regulation of p21ras activity.

Lowy, D. R., Zhang, K., DeClue, J. E. & Willumsen, B. M., 1992, In: Trends in Genetics. 7, 11-12, p. 346-51 5 p.

Research output: Contribution to journal › Review

55 Citations (Scopus)

1991

Inhibition of Cell Growth by Lovastatin Is Independent of ras Function

DeClue, J. E., Vass, W. C., Papageorge, A. G., Lowy, D. R. & Willumsen, B. M., 1991, In: Cancer Research. 51, p. 712-17

Research output: Contribution to journal › Journal article › Research › peer-review

122 Citations (Scopus)

The bovine papillomavirus E5 oncogene can cooperate with ras: identification of p21 amino acids critical for transformation by c-rasH but not v-rasH.

Willumsen, B. M., Vass, W. C., Velu, T. J., Papageorge, A. G., Schiller, J. T. & Lowy, D. R., 1991, In: Molecular and Cellular Biology. 11, 12, p. 6026-33 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

49 Citations (Scopus)

1989

Protein modification: new clue to Ras lipid glue.

Lowy, D. R. & Willumsen, B. M., 1989, In: Nature. 341, 6241, p. 384-5 1 p.

Research output: Contribution to journal › Letter

64 Citations (Scopus)

1988

Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain.

Adari, H., Lowy, D. R., Willumsen, B. M., Der, C. J. & McCormick, F., 1988, In: Science. 240, 4851, p. 518-21 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

324 Citations (Scopus)

p21-ras effector domain mutants constructed by "cassette" mutagenesis.

Stone, J. C., Vass, W. C., Willumsen, B. M. & Lowy, D. R., 1988, In: Molecular and Cellular Biology. 8, 8, p. 3565-9 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

29 Citations (Scopus)

1986

A transforming ras gene can provide an essential function ordinarily supplied by an endogenous ras gene.

Papageorge, A. G., Willumsen, B. M., Johnsen, M., Kung, H. F., Stacey, D. W., Vass, W. C. & Lowy, D. R., 1986, In: Molecular and Cellular Biology. 6, 5, p. 1843-6 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

13 Citations (Scopus)

Mutational analysis of a ras catalytic domain.

Willumsen, B. M., Papageorge, A. G., Kung, H. F., Bekesi, E., Robins, T., Johnsen, M., Vass, W. C. & Lowy, D. R., 1986, In: Molecular and Cellular Biology. 6, 7, p. 2646-54 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

125 Citations (Scopus)

1985

Transforming p21 ras protein: flexibility in the major variable region linking the catalytic and membrane-anchoring domains.

Willumsen, B. M., Papageorge, A. G., Hubbert, N., Bekesi, E., Kung, H. F. & Lowy, D. R., 1985, In: EMBO Journal. 4, 11, p. 2893-6 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

22 Citations (Scopus)

1984

Further genetic localization of the transforming sequences of the p21 v-ras gene of Harvey murine sarcoma virus.

Willumsen, B. M., Ellis, R. W., Scolnick, E. M. & Lowy, D. R., 1984, In: Journal of Virology. 49, 2, p. 601-3 2 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.

Willumsen, B. M., Norris, K., Papageorge, A. G., Hubbert, N. L. & Lowy, D. R., 1984, In: EMBO Journal. 3, 11, p. 2581-5 4 p.

Research output: Contribution to journal › Journal article › Research › peer-review

254 Citations (Scopus)

The p21 ras C-terminus is required for transformation and membrane association.

Willumsen, B. M., Christensen, A., Hubbert, N. L., Papageorge, A. G. & Lowy, D. R., 1984, In: Nature. 310, 5978, p. 583-6 3 p.

Research output: Contribution to journal › Journal article › Research › peer-review

377 Citations (Scopus)

1979

In vitro selection of high-infectious, leukemogenic virus from low-infectious, non-leukemogenic type C virus from a malignant ST/a mouse cell line.

Willumsen, B. M., 1979, In: Journal of Virology. 29, 3, p. 1213-20 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Serological identification of neoantigens on mouse fibroblasts which have undergone "spontaneous" malignant alteration in vitro.

Willumsen, B. M., Ulrich, K. & Kieler, J., 1979, In: International Journal of Cancer. 23, 2, p. 209-16 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

1977

Interaction of alleles of the relA, relC and spoT genes in Escherichia coli: analysis of the interconversion of GTP, ppGpp and pppGpp.

Fiil, N. P., Willumsen, B. M., Friesen, J. D. & von Meyenburg, K., 1977, In: Molecular Genetics and Genomics. 150, 1, p. 87-101 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

65 Citations (Scopus)

Berthe Marie Willumsen

Research output

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