Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project

Aline Jelenkovic; Yoshie Yokoyama; Reijo Sund; Chika Honda; Leonie H Bogl; Sari Aaltonen; Fuling Ji; Feng Ning; Zengchang Pang; Juan R Ordoñana; Juan F Sánchez-Romera; Lucia Colodro-Conde; S Alexandra Burt; Kelly L Klump; Sarah E Medland; Grant W Montgomery; Christian Kandler; Tom A McAdams; Thalia C Eley; Alice M Gregory; Kimberly J Saudino; Lise Dubois; Michel Boivin; Adam D Tarnoki; David L Tarnoki; Claire M A Haworth; Robert Plomin; Sevgi Y Öncel; Fazil Aliev; Maria A Stazi; Corrado Fagnani; Cristina D'Ippolito; Jeffrey M Craig; Richard Saffery; Sisira H Siribaddana; Matthew Hotopf; Athula Sumathipala; Fruhling Rijsdijk; Timothy Spector; Massimo Mangino; Genevieve Lachance; Margaret Gatz; David A Butler; Gombojav Bayasgalan; Danshiitsoodol Narandalai; Duarte L Freitas; José Antonio Maia; K Paige Harden; Elliot M Tucker-Drob; Bia Kim; Youngsook Chong; Changhee Hong; Hyun Jung Shin; Kaare Christensen; Axel Skytthe; Kirsten O Kyvik; Catherine A Derom; Robert F Vlietinck; Ruth J F Loos; Wendy Cozen; Amie E Hwang; Thomas M Mack; Mingguang He; Xiaohu Ding; Billy Chang; Judy L Silberg; Lindon J Eaves; Hermine H Maes; Tessa L Cutler; John L Hopper; Kelly Aujard; Patrik K E Magnusson; Nancy L Pedersen; Anna K Dahl Aslan; Yun-Mi Song; Sarah Yang; Kayoung Lee; Laura A Baker; Catherine Tuvblad; Morten Bjerregaard-Andersen; Henning Beck-Nielsen; Morten Sodemann; Kauko Heikkilä; Qihua Tan; Dongfeng Zhang; Gary E Swan; Ruth Krasnow; Kerry L Jang; Ariel Knafo-Noam; David Mankuta; Lior Abramson; Paul Lichtenstein; Robert F Krueger; Matt McGue; Shandell Pahlen; Per Tynelius; Glen E Duncan; Dedra Buchwald; Robin P Corley; Brooke M Huibregtse; Tracy L Nelson; Keith E Whitfield; Carol E Franz; William S Kremen; Michael J Lyons; Syuichi Ooki; Ingunn Brandt; Thomas Sevenius Nilsen; Fujio Inui; Mikio Watanabe; Meike Bartels; Toos C E M van Beijsterveldt; Jane Wardle; Clare H Llewellyn; Abigail Fisher; Esther Rebato; Nicholas G Martin; Yoshinori Iwatani; Kazuo Hayakawa; Joohon Sung; Jennifer R Harris; Gonneke Willemsen; Andreas Busjahn; Jack H Goldberg; Finn Rasmussen; Yoon-Mi Hur; Dorret I Boomsma; Thorkild I A Sørensen; Jaakko Kaprio; Karri Silventoinen

doi:10.1017/thg.2015.57

Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project

Aline Jelenkovic, Yoshie Yokoyama, Reijo Sund, Chika Honda, Leonie H Bogl, Sari Aaltonen, Fuling Ji, Feng Ning, Zengchang Pang, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, S Alexandra Burt, Kelly L Klump, Sarah E Medland, Grant W Montgomery, Christian Kandler, Tom A McAdams, Thalia C Eley, Alice M GregoryKimberly J Saudino, Lise Dubois, Michel Boivin, Adam D Tarnoki, David L Tarnoki, Claire M A Haworth, Robert Plomin, Sevgi Y Öncel, Fazil Aliev, Maria A Stazi, Corrado Fagnani, Cristina D'Ippolito, Jeffrey M Craig, Richard Saffery, Sisira H Siribaddana, Matthew Hotopf, Athula Sumathipala, Fruhling Rijsdijk, Timothy Spector, Massimo Mangino, Genevieve Lachance, Margaret Gatz, David A Butler, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Duarte L Freitas, José Antonio Maia, K Paige Harden, Elliot M Tucker-Drob, Bia Kim, Youngsook Chong, Changhee Hong, Hyun Jung Shin, Kaare Christensen, Axel Skytthe, Kirsten O Kyvik, Catherine A Derom, Robert F Vlietinck, Ruth J F Loos, Wendy Cozen, Amie E Hwang, Thomas M Mack, Mingguang He, Xiaohu Ding, Billy Chang, Judy L Silberg, Lindon J Eaves, Hermine H Maes, Tessa L Cutler, John L Hopper, Kelly Aujard, Patrik K E Magnusson, Nancy L Pedersen, Anna K Dahl Aslan, Yun-Mi Song, Sarah Yang, Kayoung Lee, Laura A Baker, Catherine Tuvblad, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Kauko Heikkilä, Qihua Tan, Dongfeng Zhang, Gary E Swan, Ruth Krasnow, Kerry L Jang, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Paul Lichtenstein, Robert F Krueger, Matt McGue, Shandell Pahlen, Per Tynelius, Glen E Duncan, Dedra Buchwald, Robin P Corley, Brooke M Huibregtse, Tracy L Nelson, Keith E Whitfield, Carol E Franz, William S Kremen, Michael J Lyons, Syuichi Ooki, Ingunn Brandt, Thomas Sevenius Nilsen, Fujio Inui, Mikio Watanabe, Meike Bartels, Toos C E M van Beijsterveldt, Jane Wardle, Clare H Llewellyn, Abigail Fisher, Esther Rebato, Nicholas G Martin, Yoshinori Iwatani, Kazuo Hayakawa, Joohon Sung, Jennifer R Harris, Gonneke Willemsen, Andreas Busjahn, Jack H Goldberg, Finn Rasmussen, Yoon-Mi Hur, Dorret I Boomsma, Thorkild I A Sørensen, Jaakko Kaprio, Karri Silventoinen

19 Citationer (Scopus)

Abstract

A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.

Originalsprog	Engelsk
Tidsskrift	Twin Research and Human Genetics
Vol/bind	18
Udgave nummer	5
Sider (fra-til)	557-70
Antal sider	14
ISSN	1832-4274
DOI	https://doi.org/10.1017/thg.2015.57
Status	Udgivet - 17 sep. 2015

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10.1017/thg.2015.57

div-class-title-zygosity-differences-in-height-and-body-mass-index-of-twins-from-infancy-to-old-age-a-study-of-the-codatwins-project-div.pdfForlagets udgivne version, 399 KB

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Jelenkovic, A., Yokoyama, Y., Sund, R., Honda, C., Bogl, L. H., Aaltonen, S., Ji, F., Ning, F., Pang, Z., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Burt, S. A., Klump, K. L., Medland, S. E., Montgomery, G. W., Kandler, C., McAdams, T. A., Eley, T. C., ... Silventoinen, K. (2015). Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project. Twin Research and Human Genetics, 18(5), 557-70. https://doi.org/10.1017/thg.2015.57

Jelenkovic, A, Yokoyama, Y, Sund, R, Honda, C, Bogl, LH, Aaltonen, S, Ji, F, Ning, F, Pang, Z, Ordoñana, JR, Sánchez-Romera, JF, Colodro-Conde, L, Burt, SA, Klump, KL, Medland, SE, Montgomery, GW, Kandler, C, McAdams, TA, Eley, TC, Gregory, AM, Saudino, KJ, Dubois, L, Boivin, M, Tarnoki, AD, Tarnoki, DL, Haworth, CMA, Plomin, R, Öncel, SY, Aliev, F, Stazi, MA, Fagnani, C, D'Ippolito, C, Craig, JM, Saffery, R, Siribaddana, SH, Hotopf, M, Sumathipala, A, Rijsdijk, F, Spector, T, Mangino, M, Lachance, G, Gatz, M, Butler, DA, Bayasgalan, G, Narandalai, D, Freitas, DL, Maia, JA, Harden, KP, Tucker-Drob, EM, Kim, B, Chong, Y, Hong, C, Shin, HJ, Christensen, K, Skytthe, A, Kyvik, KO, Derom, CA, Vlietinck, RF, Loos, RJF, Cozen, W, Hwang, AE, Mack, TM, He, M, Ding, X, Chang, B, Silberg, JL, Eaves, LJ, Maes, HH, Cutler, TL, Hopper, JL, Aujard, K, Magnusson, PKE, Pedersen, NL, Aslan, AKD, Song, Y-M, Yang, S, Lee, K, Baker, LA, Tuvblad, C, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Heikkilä, K, Tan, Q, Zhang, D, Swan, GE, Krasnow, R, Jang, KL, Knafo-Noam, A, Mankuta, D, Abramson, L, Lichtenstein, P, Krueger, RF, McGue, M, Pahlen, S, Tynelius, P, Duncan, GE, Buchwald, D, Corley, RP, Huibregtse, BM, Nelson, TL, Whitfield, KE, Franz, CE, Kremen, WS, Lyons, MJ, Ooki, S, Brandt, I, Nilsen, TS, Inui, F, Watanabe, M, Bartels, M, van Beijsterveldt, TCEM, Wardle, J, Llewellyn, CH, Fisher, A, Rebato, E, Martin, NG, Iwatani, Y, Hayakawa, K, Sung, J, Harris, JR, Willemsen, G, Busjahn, A, Goldberg, JH, Rasmussen, F, Hur, Y-M, Boomsma, DI, Sørensen, TIA, Kaprio, J & Silventoinen, K 2015, 'Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project', Twin Research and Human Genetics, bind 18, nr. 5, s. 557-70. https://doi.org/10.1017/thg.2015.57

@article{e52ff1c748624fed975e43e650ef75e3,

title = "Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project",

abstract = "A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.",

author = "Aline Jelenkovic and Yoshie Yokoyama and Reijo Sund and Chika Honda and Bogl, {Leonie H} and Sari Aaltonen and Fuling Ji and Feng Ning and Zengchang Pang and Ordo{\~n}ana, {Juan R} and S{\'a}nchez-Romera, {Juan F} and Lucia Colodro-Conde and Burt, {S Alexandra} and Klump, {Kelly L} and Medland, {Sarah E} and Montgomery, {Grant W} and Christian Kandler and McAdams, {Tom A} and Eley, {Thalia C} and Gregory, {Alice M} and Saudino, {Kimberly J} and Lise Dubois and Michel Boivin and Tarnoki, {Adam D} and Tarnoki, {David L} and Haworth, {Claire M A} and Robert Plomin and {\"O}ncel, {Sevgi Y} and Fazil Aliev and Stazi, {Maria A} and Corrado Fagnani and Cristina D'Ippolito and Craig, {Jeffrey M} and Richard Saffery and Siribaddana, {Sisira H} and Matthew Hotopf and Athula Sumathipala and Fruhling Rijsdijk and Timothy Spector and Massimo Mangino and Genevieve Lachance and Margaret Gatz and Butler, {David A} and Gombojav Bayasgalan and Danshiitsoodol Narandalai and Freitas, {Duarte L} and Maia, {Jos{\'e} Antonio} and Harden, {K Paige} and Tucker-Drob, {Elliot M} and Bia Kim and Youngsook Chong and Changhee Hong and Shin, {Hyun Jung} and Kaare Christensen and Axel Skytthe and Kyvik, {Kirsten O} and Derom, {Catherine A} and Vlietinck, {Robert F} and Loos, {Ruth J F} and Wendy Cozen and Hwang, {Amie E} and Mack, {Thomas M} and Mingguang He and Xiaohu Ding and Billy Chang and Silberg, {Judy L} and Eaves, {Lindon J} and Maes, {Hermine H} and Cutler, {Tessa L} and Hopper, {John L} and Kelly Aujard and Magnusson, {Patrik K E} and Pedersen, {Nancy L} and Aslan, {Anna K Dahl} and Yun-Mi Song and Sarah Yang and Kayoung Lee and Baker, {Laura A} and Catherine Tuvblad and Morten Bjerregaard-Andersen and Henning Beck-Nielsen and Morten Sodemann and Kauko Heikkil{\"a} and Qihua Tan and Dongfeng Zhang and Swan, {Gary E} and Ruth Krasnow and Jang, {Kerry L} and Ariel Knafo-Noam and David Mankuta and Lior Abramson and Paul Lichtenstein and Krueger, {Robert F} and Matt McGue and Shandell Pahlen and Per Tynelius and Duncan, {Glen E} and Dedra Buchwald and Corley, {Robin P} and Huibregtse, {Brooke M} and Nelson, {Tracy L} and Whitfield, {Keith E} and Franz, {Carol E} and Kremen, {William S} and Lyons, {Michael J} and Syuichi Ooki and Ingunn Brandt and Nilsen, {Thomas Sevenius} and Fujio Inui and Mikio Watanabe and Meike Bartels and {van Beijsterveldt}, {Toos C E M} and Jane Wardle and Llewellyn, {Clare H} and Abigail Fisher and Esther Rebato and Martin, {Nicholas G} and Yoshinori Iwatani and Kazuo Hayakawa and Joohon Sung and Harris, {Jennifer R} and Gonneke Willemsen and Andreas Busjahn and Goldberg, {Jack H} and Finn Rasmussen and Yoon-Mi Hur and Boomsma, {Dorret I} and S{\o}rensen, {Thorkild I A} and Jaakko Kaprio and Karri Silventoinen",

year = "2015",

month = sep,

day = "17",

doi = "10.1017/thg.2015.57",

language = "English",

volume = "18",

pages = "557--70",

journal = "Twin Research",

issn = "1832-4274",

publisher = "Cambridge University Press",

number = "5",

}

TY - JOUR

T1 - Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age

T2 - A Study of the CODATwins Project

AU - Jelenkovic, Aline

AU - Yokoyama, Yoshie

AU - Sund, Reijo

AU - Honda, Chika

AU - Bogl, Leonie H

AU - Aaltonen, Sari

AU - Ji, Fuling

AU - Ning, Feng

AU - Pang, Zengchang

AU - Ordoñana, Juan R

AU - Sánchez-Romera, Juan F

AU - Colodro-Conde, Lucia

AU - Burt, S Alexandra

AU - Klump, Kelly L

AU - Medland, Sarah E

AU - Montgomery, Grant W

AU - Kandler, Christian

AU - McAdams, Tom A

AU - Eley, Thalia C

AU - Gregory, Alice M

AU - Saudino, Kimberly J

AU - Dubois, Lise

AU - Boivin, Michel

AU - Tarnoki, Adam D

AU - Tarnoki, David L

AU - Haworth, Claire M A

AU - Plomin, Robert

AU - Öncel, Sevgi Y

AU - Aliev, Fazil

AU - Stazi, Maria A

AU - Fagnani, Corrado

AU - D'Ippolito, Cristina

AU - Craig, Jeffrey M

AU - Saffery, Richard

AU - Siribaddana, Sisira H

AU - Hotopf, Matthew

AU - Sumathipala, Athula

AU - Rijsdijk, Fruhling

AU - Spector, Timothy

AU - Mangino, Massimo

AU - Lachance, Genevieve

AU - Gatz, Margaret

AU - Butler, David A

AU - Bayasgalan, Gombojav

AU - Narandalai, Danshiitsoodol

AU - Freitas, Duarte L

AU - Maia, José Antonio

AU - Harden, K Paige

AU - Tucker-Drob, Elliot M

AU - Kim, Bia

AU - Chong, Youngsook

AU - Hong, Changhee

AU - Shin, Hyun Jung

AU - Christensen, Kaare

AU - Skytthe, Axel

AU - Kyvik, Kirsten O

AU - Derom, Catherine A

AU - Vlietinck, Robert F

AU - Loos, Ruth J F

AU - Cozen, Wendy

AU - Hwang, Amie E

AU - Mack, Thomas M

AU - He, Mingguang

AU - Ding, Xiaohu

AU - Chang, Billy

AU - Silberg, Judy L

AU - Eaves, Lindon J

AU - Maes, Hermine H

AU - Cutler, Tessa L

AU - Hopper, John L

AU - Aujard, Kelly

AU - Magnusson, Patrik K E

AU - Pedersen, Nancy L

AU - Aslan, Anna K Dahl

AU - Song, Yun-Mi

AU - Yang, Sarah

AU - Lee, Kayoung

AU - Baker, Laura A

AU - Tuvblad, Catherine

AU - Bjerregaard-Andersen, Morten

AU - Beck-Nielsen, Henning

AU - Sodemann, Morten

AU - Heikkilä, Kauko

AU - Tan, Qihua

AU - Zhang, Dongfeng

AU - Swan, Gary E

AU - Krasnow, Ruth

AU - Jang, Kerry L

AU - Knafo-Noam, Ariel

AU - Mankuta, David

AU - Abramson, Lior

AU - Lichtenstein, Paul

AU - Krueger, Robert F

AU - McGue, Matt

AU - Pahlen, Shandell

AU - Tynelius, Per

AU - Duncan, Glen E

AU - Buchwald, Dedra

AU - Corley, Robin P

AU - Huibregtse, Brooke M

AU - Nelson, Tracy L

AU - Whitfield, Keith E

AU - Franz, Carol E

AU - Kremen, William S

AU - Lyons, Michael J

AU - Ooki, Syuichi

AU - Brandt, Ingunn

AU - Nilsen, Thomas Sevenius

AU - Inui, Fujio

AU - Watanabe, Mikio

AU - Bartels, Meike

AU - van Beijsterveldt, Toos C E M

AU - Wardle, Jane

AU - Llewellyn, Clare H

AU - Fisher, Abigail

AU - Rebato, Esther

AU - Martin, Nicholas G

AU - Iwatani, Yoshinori

AU - Hayakawa, Kazuo

AU - Sung, Joohon

AU - Harris, Jennifer R

AU - Willemsen, Gonneke

AU - Busjahn, Andreas

AU - Goldberg, Jack H

AU - Rasmussen, Finn

AU - Hur, Yoon-Mi

AU - Boomsma, Dorret I

AU - Sørensen, Thorkild I A

AU - Kaprio, Jaakko

AU - Silventoinen, Karri

PY - 2015/9/17

Y1 - 2015/9/17

N2 - A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.

AB - A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.

U2 - 10.1017/thg.2015.57

DO - 10.1017/thg.2015.57

M3 - Journal article

C2 - 26337138

SN - 1832-4274

VL - 18

SP - 557

EP - 570

JO - Twin Research

JF - Twin Research

IS - 5

ER -

Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project

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