Women born preterm or with inappropriate weight for gestational age are at risk of subsequent gestational diabetes and pre-eclampsia

Rasmus á Rogvi; Julie Lyng Forman; Peter Damm; Gorm Greisen

doi:10.1371/journal.pone.0034001

Women born preterm or with inappropriate weight for gestational age are at risk of subsequent gestational diabetes and pre-eclampsia

Rasmus á Rogvi, Julie Lyng Forman, Peter Damm, Gorm Greisen

24 Citationer (Scopus)

Abstract

Introduction: Low birthweight, which can be caused by inappropriate intrauterine growth or prematurity, is associated with development of gestational diabetes mellitus (GDM) as well as pre-eclampsia later in life, but the relative effects of prematurity and inappropriate intrauterine growth remain uncertain. Methods: Through nation-wide registries we identified all Danish mothers in the years 1989-2007. Two separate cohorts consisting mothers born 1974-1977 (n = 84219) and 1978-1981 (n = 32376) were studied, due to different methods of registering birthweight and gestational age in the two periods. Data was linked with information on GDM, pre-eclampsia and education. Results: In a multivariate logistic regression model the odds of developing GDM was increased by 5-7% for each week the mother was born before term (p = 0.018 for 1974-1977, p = 0.048 for 1978-1981), while the odds were increased by 13-17% for each standard deviation (SD) reduction in birthweight for gestational age for those who were small or normal for gestational age (p<0.0001 and p = 0.035) and increased by 118-122% for each SD increase above the normal range (p<0.0001 and p = 0.024). The odds of pre-eclampsia was increased by 3-5% for each week the mother was born before term (p = 0.064 and p = 0.04), while the odds were increased 11-12% for each SD reduction in birthweight for gestational age (p<0.0001 and p = 0.0002). Conclusion: In this cohort of young Danish mothers, being born premature or with increasingly low birthweight for gestational age was associated with an increased risk of GDM and pre-eclampsia in adulthood, while increasingly high birthweight for gestational age was associated with an increased risk of GDM and a decreased risk of pre-eclampsia. Inappropriate weight for gestational age was a more important risk factor than prematurity.

Originalsprog	Engelsk
Artikelnummer	e34001
Tidsskrift	P L o S One
Vol/bind	7
Udgave nummer	3
Antal sider	1
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0034001
Status	Udgivet - 29 mar. 2012

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10.1371/journal.pone.0034001

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title = "Women born preterm or with inappropriate weight for gestational age are at risk of subsequent gestational diabetes and pre-eclampsia",

abstract = "Introduction: Low birthweight, which can be caused by inappropriate intrauterine growth or prematurity, is associated with development of gestational diabetes mellitus (GDM) as well as pre-eclampsia later in life, but the relative effects of prematurity and inappropriate intrauterine growth remain uncertain. Methods: Through nation-wide registries we identified all Danish mothers in the years 1989-2007. Two separate cohorts consisting mothers born 1974-1977 (n = 84219) and 1978-1981 (n = 32376) were studied, due to different methods of registering birthweight and gestational age in the two periods. Data was linked with information on GDM, pre-eclampsia and education. Results: In a multivariate logistic regression model the odds of developing GDM was increased by 5-7% for each week the mother was born before term (p = 0.018 for 1974-1977, p = 0.048 for 1978-1981), while the odds were increased by 13-17% for each standard deviation (SD) reduction in birthweight for gestational age for those who were small or normal for gestational age (p<0.0001 and p = 0.035) and increased by 118-122% for each SD increase above the normal range (p<0.0001 and p = 0.024). The odds of pre-eclampsia was increased by 3-5% for each week the mother was born before term (p = 0.064 and p = 0.04), while the odds were increased 11-12% for each SD reduction in birthweight for gestational age (p<0.0001 and p = 0.0002). Conclusion: In this cohort of young Danish mothers, being born premature or with increasingly low birthweight for gestational age was associated with an increased risk of GDM and pre-eclampsia in adulthood, while increasingly high birthweight for gestational age was associated with an increased risk of GDM and a decreased risk of pre-eclampsia. Inappropriate weight for gestational age was a more important risk factor than prematurity.",

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T1 - Women born preterm or with inappropriate weight for gestational age are at risk of subsequent gestational diabetes and pre-eclampsia

AU - á Rogvi, Rasmus

AU - Forman, Julie Lyng

AU - Damm, Peter

AU - Greisen, Gorm

PY - 2012/3/29

Y1 - 2012/3/29

N2 - Introduction: Low birthweight, which can be caused by inappropriate intrauterine growth or prematurity, is associated with development of gestational diabetes mellitus (GDM) as well as pre-eclampsia later in life, but the relative effects of prematurity and inappropriate intrauterine growth remain uncertain. Methods: Through nation-wide registries we identified all Danish mothers in the years 1989-2007. Two separate cohorts consisting mothers born 1974-1977 (n = 84219) and 1978-1981 (n = 32376) were studied, due to different methods of registering birthweight and gestational age in the two periods. Data was linked with information on GDM, pre-eclampsia and education. Results: In a multivariate logistic regression model the odds of developing GDM was increased by 5-7% for each week the mother was born before term (p = 0.018 for 1974-1977, p = 0.048 for 1978-1981), while the odds were increased by 13-17% for each standard deviation (SD) reduction in birthweight for gestational age for those who were small or normal for gestational age (p<0.0001 and p = 0.035) and increased by 118-122% for each SD increase above the normal range (p<0.0001 and p = 0.024). The odds of pre-eclampsia was increased by 3-5% for each week the mother was born before term (p = 0.064 and p = 0.04), while the odds were increased 11-12% for each SD reduction in birthweight for gestational age (p<0.0001 and p = 0.0002). Conclusion: In this cohort of young Danish mothers, being born premature or with increasingly low birthweight for gestational age was associated with an increased risk of GDM and pre-eclampsia in adulthood, while increasingly high birthweight for gestational age was associated with an increased risk of GDM and a decreased risk of pre-eclampsia. Inappropriate weight for gestational age was a more important risk factor than prematurity.

AB - Introduction: Low birthweight, which can be caused by inappropriate intrauterine growth or prematurity, is associated with development of gestational diabetes mellitus (GDM) as well as pre-eclampsia later in life, but the relative effects of prematurity and inappropriate intrauterine growth remain uncertain. Methods: Through nation-wide registries we identified all Danish mothers in the years 1989-2007. Two separate cohorts consisting mothers born 1974-1977 (n = 84219) and 1978-1981 (n = 32376) were studied, due to different methods of registering birthweight and gestational age in the two periods. Data was linked with information on GDM, pre-eclampsia and education. Results: In a multivariate logistic regression model the odds of developing GDM was increased by 5-7% for each week the mother was born before term (p = 0.018 for 1974-1977, p = 0.048 for 1978-1981), while the odds were increased by 13-17% for each standard deviation (SD) reduction in birthweight for gestational age for those who were small or normal for gestational age (p<0.0001 and p = 0.035) and increased by 118-122% for each SD increase above the normal range (p<0.0001 and p = 0.024). The odds of pre-eclampsia was increased by 3-5% for each week the mother was born before term (p = 0.064 and p = 0.04), while the odds were increased 11-12% for each SD reduction in birthweight for gestational age (p<0.0001 and p = 0.0002). Conclusion: In this cohort of young Danish mothers, being born premature or with increasingly low birthweight for gestational age was associated with an increased risk of GDM and pre-eclampsia in adulthood, while increasingly high birthweight for gestational age was associated with an increased risk of GDM and a decreased risk of pre-eclampsia. Inappropriate weight for gestational age was a more important risk factor than prematurity.

U2 - 10.1371/journal.pone.0034001

DO - 10.1371/journal.pone.0034001

M3 - Journal article

C2 - 22479500

SN - 1932-6203

VL - 7

JO - PLoS Computational Biology

JF - PLoS Computational Biology

IS - 3

M1 - e34001

ER -

Women born preterm or with inappropriate weight for gestational age are at risk of subsequent gestational diabetes and pre-eclampsia

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