TY - JOUR
T1 - Whole-Genome Sequencing of African Dogs Provides Insights into Adaptations against Tropical Parasites
AU - Liu, Yan-hu
AU - Wang, Lu
AU - Xu, Tao
AU - Guo, Xiaomin
AU - Li, Yang
AU - Yin, Ting-ting
AU - Yang, He-chuan
AU - Hu, Yang
AU - Adeola, Adeniyi C
AU - Sanke, Oscar J
AU - Otecko, Newton O
AU - Wang, Meng
AU - Ma, Yaping
AU - Charles, Olaogun S
AU - Sinding, Mikkel-holger S
AU - Gopalakrishnan, Shyam
AU - Alfredo Samaniego, José
AU - Hansen, Anders J
AU - Fernandes, Carlos
AU - Gaubert, Philippe
AU - Budd, Jane
AU - Dawuda, Philip M
AU - Knispel Rueness, Eli
AU - Jiang, Lubin
AU - Zhai, Weiwei
AU - Gilbert, M Thomas P
AU - Peng, Min-sheng
AU - Qi, Xiaopeng
AU - Wang, Guo-dong
AU - Zhang, Ya-ping
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Natural selection in domestic dogs is of great interest in evolutionary biology since dogs have migrated to every inhabited continent of the world alongside humans, and adapted to diverse environments. Here, we explored their demographic history and genetic basis of adaptation to the tropical African environment using whole genome analyses of 19 African indigenous dogs from Nigeria. Demographic analysis suggests that the ancestors of these dogs migrated into Africa from Eurasia 14,000 years ago and underwent a severe founder effect before population expansion. Admixture analysis further reveals that African dog genomes contain about 1.88–3.50% introgression from African golden wolves (Canis anthus). Population genetic analysis identifies 50 positively selected genes linked with immunity, angiogenesis, ultraviolet protection, as well as insulin secretion and sensitivity that may contribute to adaptation to tropical conditions. One of the positively selected genes, adhesion G protein-coupled receptor E1 (ADGRE1), has also been found to be association with severe malaria resistance in African human populations. Functional assessments showed that ADGRE1 provides protective host defense against Plasmodium infections. This result, together with the fact that the inflammatory response to canine babesiosis is similar to complicated falciparum malaria in humans, support the dogs as a model for the study of malaria control and treatment.
AB - Natural selection in domestic dogs is of great interest in evolutionary biology since dogs have migrated to every inhabited continent of the world alongside humans, and adapted to diverse environments. Here, we explored their demographic history and genetic basis of adaptation to the tropical African environment using whole genome analyses of 19 African indigenous dogs from Nigeria. Demographic analysis suggests that the ancestors of these dogs migrated into Africa from Eurasia 14,000 years ago and underwent a severe founder effect before population expansion. Admixture analysis further reveals that African dog genomes contain about 1.88–3.50% introgression from African golden wolves (Canis anthus). Population genetic analysis identifies 50 positively selected genes linked with immunity, angiogenesis, ultraviolet protection, as well as insulin secretion and sensitivity that may contribute to adaptation to tropical conditions. One of the positively selected genes, adhesion G protein-coupled receptor E1 (ADGRE1), has also been found to be association with severe malaria resistance in African human populations. Functional assessments showed that ADGRE1 provides protective host defense against Plasmodium infections. This result, together with the fact that the inflammatory response to canine babesiosis is similar to complicated falciparum malaria in humans, support the dogs as a model for the study of malaria control and treatment.
U2 - 10.1093/molbev/msx258
DO - 10.1093/molbev/msx258
M3 - Letter
C2 - 29040727
SN - 0737-4038
VL - 35
SP - 287
EP - 298
JO - MOLECULAR BIOLOGY AND EVOLUTION
JF - MOLECULAR BIOLOGY AND EVOLUTION
IS - 2
ER -
