Whole-body magnetic resonance angiography at 3 tesla using a hybrid protocol in patients with peripheral arterial disease

Yousef W Nielsen; Jonas P Eiberg; Vibeke B Logager; Torben V Schroeder; Sven Just; Henrik S Thomsen; Yousef W Nielsen; Jonas P Eiberg; Vibeke B Logager; Torben V Schroeder; Sven Just; Henrik S Thomsen

doi:10.1007/s00270-009-9549-z

Whole-body magnetic resonance angiography at 3 tesla using a hybrid protocol in patients with peripheral arterial disease

Yousef W Nielsen, Jonas P Eiberg, Vibeke B Logager, Torben V Schroeder, Sven Just, Henrik S Thomsen, Yousef W Nielsen, Jonas P Eiberg, Vibeke B Logager, Torben V Schroeder, Sven Just, Henrik S Thomsen

7 Citationer (Scopus)

Abstract

The purpose of this study was to determine the diagnostic performance of 3T whole-body magnetic resonance angiography (WB-MRA) using a hybrid protocol in comparison with a standard protocol in patients with peripheral arterial disease (PAD). In 26 consecutive patients with PAD two different protocols were used for WB-MRA: a standard sequential protocol (n = 13) and a hybrid protocol (n = 13). WB-MRA was performed using a gradient echo sequence, body coil for signal reception, and gadoterate meglumine as contrast agent (0.3 mmol/kg body weight). Two blinded observers evaluated all WB-MRA examinations with regard to presence of stenoses, as well as diagnostic quality and degree of venous contamination in each of the four stations used in WB-MRA. Digital subtraction angiography served as the method of reference. Sensitivity for detecting significant arterial disease (luminal narrowing > or = 50%) using standard-protocol WB-MRA for the two observers was 0.63 (95%CI: 0.51-0.73) and 0.66 (0.58-0.78). Specificities were 0.94 (0.91-0.97) and 0.96 (0.92-0.98), respectively. In the hybrid protocol WB-MRA sensitivities were 0.75 (0.64-0.84) and 0.70 (0.58-0.8), respectively. Specificities were 0.93 (0.88-0.96) and 0.95 (0.91-0.97). Interobserver agreement was good using both the standard and the hybrid protocol, with kappa = 0.62 (0.44-0.67) and kappa = 0.70 (0.59-0.79), respectively. WB-MRA quality scores were significantly higher in the lower leg using the hybrid protocol compared to standard protocol (p = 0.003 and p = 0.03, observers 1 and 2). Distal venous contamination scores were significantly lower with the hybrid protocol (p = 0.02 and p = 0.01, observers 1 and 2). In conclusion, hybrid-protocol WB-MRA shows a better diagnostic performance than standard protocol WB-MRA at 3 T in patients with PAD.

Originalsprog	Engelsk
Tidsskrift	Cardiovascular and Interventional Radiology
Vol/bind	32
Udgave nummer	5
Sider (fra-til)	877-86
Antal sider	10
ISSN	0174-1551
DOI	https://doi.org/10.1007/s00270-009-9549-z https://doi.org/10.1007/s00270-009-9549-z
Status	Udgivet - 1 sep. 2009

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Nielsen, Y. W., Eiberg, J. P., Logager, V. B., Schroeder, T. V., Just, S., Thomsen, H. S., Nielsen, Y. W., Eiberg, J. P., Logager, V. B., Schroeder, T. V., Just, S., & Thomsen, H. S. (2009). Whole-body magnetic resonance angiography at 3 tesla using a hybrid protocol in patients with peripheral arterial disease. Cardiovascular and Interventional Radiology, 32(5), 877-86. https://doi.org/10.1007/s00270-009-9549-z, https://doi.org/10.1007/s00270-009-9549-z

Nielsen, YW, Eiberg, JP, Logager, VB, Schroeder, TV, Just, S, Thomsen, HS, Nielsen, YW, Eiberg, JP, Logager, VB, Schroeder, TV, Just, S & Thomsen, HS 2009, 'Whole-body magnetic resonance angiography at 3 tesla using a hybrid protocol in patients with peripheral arterial disease', Cardiovascular and Interventional Radiology, bind 32, nr. 5, s. 877-86. https://doi.org/10.1007/s00270-009-9549-z, https://doi.org/10.1007/s00270-009-9549-z

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title = "Whole-body magnetic resonance angiography at 3 tesla using a hybrid protocol in patients with peripheral arterial disease",

abstract = "The purpose of this study was to determine the diagnostic performance of 3T whole-body magnetic resonance angiography (WB-MRA) using a hybrid protocol in comparison with a standard protocol in patients with peripheral arterial disease (PAD). In 26 consecutive patients with PAD two different protocols were used for WB-MRA: a standard sequential protocol (n = 13) and a hybrid protocol (n = 13). WB-MRA was performed using a gradient echo sequence, body coil for signal reception, and gadoterate meglumine as contrast agent (0.3 mmol/kg body weight). Two blinded observers evaluated all WB-MRA examinations with regard to presence of stenoses, as well as diagnostic quality and degree of venous contamination in each of the four stations used in WB-MRA. Digital subtraction angiography served as the method of reference. Sensitivity for detecting significant arterial disease (luminal narrowing > or = 50%) using standard-protocol WB-MRA for the two observers was 0.63 (95%CI: 0.51-0.73) and 0.66 (0.58-0.78). Specificities were 0.94 (0.91-0.97) and 0.96 (0.92-0.98), respectively. In the hybrid protocol WB-MRA sensitivities were 0.75 (0.64-0.84) and 0.70 (0.58-0.8), respectively. Specificities were 0.93 (0.88-0.96) and 0.95 (0.91-0.97). Interobserver agreement was good using both the standard and the hybrid protocol, with kappa = 0.62 (0.44-0.67) and kappa = 0.70 (0.59-0.79), respectively. WB-MRA quality scores were significantly higher in the lower leg using the hybrid protocol compared to standard protocol (p = 0.003 and p = 0.03, observers 1 and 2). Distal venous contamination scores were significantly lower with the hybrid protocol (p = 0.02 and p = 0.01, observers 1 and 2). In conclusion, hybrid-protocol WB-MRA shows a better diagnostic performance than standard protocol WB-MRA at 3 T in patients with PAD.",

author = "Nielsen, {Yousef W} and Eiberg, {Jonas P} and Logager, {Vibeke B} and Schroeder, {Torben V} and Sven Just and Thomsen, {Henrik S} and Nielsen, {Yousef W} and Eiberg, {Jonas P} and Logager, {Vibeke B} and Schroeder, {Torben V} and Sven Just and Thomsen, {Henrik S}",

note = "Keywords: Adult; Aged; Aged, 80 and over; Angiography, Digital Subtraction; Contrast Media; Female; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Angiography; Male; Meglumine; Middle Aged; Organometallic Compounds; Peripheral Vascular Diseases; Sensitivity and Specificity; Statistics, Nonparametric; Whole Body Imaging",

year = "2009",

month = sep,

day = "1",

doi = "10.1007/s00270-009-9549-z",

language = "English",

volume = "32",

pages = "877--86",

journal = "CardioVascular and Interventional Radiology",

issn = "0174-1551",

publisher = "Springer",

number = "5",

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TY - JOUR

T1 - Whole-body magnetic resonance angiography at 3 tesla using a hybrid protocol in patients with peripheral arterial disease

AU - Nielsen, Yousef W

AU - Eiberg, Jonas P

AU - Logager, Vibeke B

AU - Schroeder, Torben V

AU - Just, Sven

AU - Thomsen, Henrik S

AU - Nielsen, Yousef W

AU - Eiberg, Jonas P

AU - Logager, Vibeke B

AU - Schroeder, Torben V

AU - Just, Sven

AU - Thomsen, Henrik S

N1 - Keywords: Adult; Aged; Aged, 80 and over; Angiography, Digital Subtraction; Contrast Media; Female; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Angiography; Male; Meglumine; Middle Aged; Organometallic Compounds; Peripheral Vascular Diseases; Sensitivity and Specificity; Statistics, Nonparametric; Whole Body Imaging

PY - 2009/9/1

Y1 - 2009/9/1

N2 - The purpose of this study was to determine the diagnostic performance of 3T whole-body magnetic resonance angiography (WB-MRA) using a hybrid protocol in comparison with a standard protocol in patients with peripheral arterial disease (PAD). In 26 consecutive patients with PAD two different protocols were used for WB-MRA: a standard sequential protocol (n = 13) and a hybrid protocol (n = 13). WB-MRA was performed using a gradient echo sequence, body coil for signal reception, and gadoterate meglumine as contrast agent (0.3 mmol/kg body weight). Two blinded observers evaluated all WB-MRA examinations with regard to presence of stenoses, as well as diagnostic quality and degree of venous contamination in each of the four stations used in WB-MRA. Digital subtraction angiography served as the method of reference. Sensitivity for detecting significant arterial disease (luminal narrowing > or = 50%) using standard-protocol WB-MRA for the two observers was 0.63 (95%CI: 0.51-0.73) and 0.66 (0.58-0.78). Specificities were 0.94 (0.91-0.97) and 0.96 (0.92-0.98), respectively. In the hybrid protocol WB-MRA sensitivities were 0.75 (0.64-0.84) and 0.70 (0.58-0.8), respectively. Specificities were 0.93 (0.88-0.96) and 0.95 (0.91-0.97). Interobserver agreement was good using both the standard and the hybrid protocol, with kappa = 0.62 (0.44-0.67) and kappa = 0.70 (0.59-0.79), respectively. WB-MRA quality scores were significantly higher in the lower leg using the hybrid protocol compared to standard protocol (p = 0.003 and p = 0.03, observers 1 and 2). Distal venous contamination scores were significantly lower with the hybrid protocol (p = 0.02 and p = 0.01, observers 1 and 2). In conclusion, hybrid-protocol WB-MRA shows a better diagnostic performance than standard protocol WB-MRA at 3 T in patients with PAD.

AB - The purpose of this study was to determine the diagnostic performance of 3T whole-body magnetic resonance angiography (WB-MRA) using a hybrid protocol in comparison with a standard protocol in patients with peripheral arterial disease (PAD). In 26 consecutive patients with PAD two different protocols were used for WB-MRA: a standard sequential protocol (n = 13) and a hybrid protocol (n = 13). WB-MRA was performed using a gradient echo sequence, body coil for signal reception, and gadoterate meglumine as contrast agent (0.3 mmol/kg body weight). Two blinded observers evaluated all WB-MRA examinations with regard to presence of stenoses, as well as diagnostic quality and degree of venous contamination in each of the four stations used in WB-MRA. Digital subtraction angiography served as the method of reference. Sensitivity for detecting significant arterial disease (luminal narrowing > or = 50%) using standard-protocol WB-MRA for the two observers was 0.63 (95%CI: 0.51-0.73) and 0.66 (0.58-0.78). Specificities were 0.94 (0.91-0.97) and 0.96 (0.92-0.98), respectively. In the hybrid protocol WB-MRA sensitivities were 0.75 (0.64-0.84) and 0.70 (0.58-0.8), respectively. Specificities were 0.93 (0.88-0.96) and 0.95 (0.91-0.97). Interobserver agreement was good using both the standard and the hybrid protocol, with kappa = 0.62 (0.44-0.67) and kappa = 0.70 (0.59-0.79), respectively. WB-MRA quality scores were significantly higher in the lower leg using the hybrid protocol compared to standard protocol (p = 0.003 and p = 0.03, observers 1 and 2). Distal venous contamination scores were significantly lower with the hybrid protocol (p = 0.02 and p = 0.01, observers 1 and 2). In conclusion, hybrid-protocol WB-MRA shows a better diagnostic performance than standard protocol WB-MRA at 3 T in patients with PAD.

U2 - 10.1007/s00270-009-9549-z

DO - 10.1007/s00270-009-9549-z

M3 - Journal article

C2 - 19296155

SN - 0174-1551

VL - 32

SP - 877

EP - 886

JO - CardioVascular and Interventional Radiology

JF - CardioVascular and Interventional Radiology

IS - 5

ER -

Whole-body magnetic resonance angiography at 3 tesla using a hybrid protocol in patients with peripheral arterial disease

Abstract

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