When the PilZ don't work: effectors for cyclic di-GMP action in bacteria

TY - JOUR

T1 - When the PilZ don't work

T2 - effectors for cyclic di-GMP action in bacteria

AU - Ryan, Robert P

AU - Tolker-Nielsen, Tim

AU - Dow, J Maxwell

N1 - Copyright © 2012 Elsevier Ltd. All rights reserved.

PY - 2012/5

Y1 - 2012/5

N2 - The second messenger cyclic di-GMP has emerged as a central regulator of many important bacterial processes including biofilm formation and virulence. Although the pathways of cyclic di-GMP synthesis and degradation have been established, the mechanisms by which this second messenger exerts its action on diverse cellular functions remain relatively poorly understood. Recent studies report considerable advances in identifying different classes of cyclic di-GMP effectors; these include the PilZ protein domain, transcription factors, proteins involved in RNA processing and riboswitches. Here, we review this range of cyclic di-GMP effectors and the biological processes that they govern using examples from several different bacteria.

AB - The second messenger cyclic di-GMP has emerged as a central regulator of many important bacterial processes including biofilm formation and virulence. Although the pathways of cyclic di-GMP synthesis and degradation have been established, the mechanisms by which this second messenger exerts its action on diverse cellular functions remain relatively poorly understood. Recent studies report considerable advances in identifying different classes of cyclic di-GMP effectors; these include the PilZ protein domain, transcription factors, proteins involved in RNA processing and riboswitches. Here, we review this range of cyclic di-GMP effectors and the biological processes that they govern using examples from several different bacteria.

U2 - 10.1016/j.tim.2012.02.008

DO - 10.1016/j.tim.2012.02.008

M3 - Journal article

C2 - 22444828

SN - 0972-7736

VL - 20

SP - 235

EP - 242

JO - Current Trends in Microbiology

JF - Current Trends in Microbiology

IS - 5

ER -