Wexner score and quality of life in women with obstetric anal sphincter injury

Hanna Jango; Jens Langhoff-Roos; Susanne Rosthoj; Abelone Sakse

doi:10.1007/s00192-019-04134-1

Wexner score and quality of life in women with obstetric anal sphincter injury

Hanna Jango, Jens Langhoff-Roos, Susanne Rosthoj, Abelone Sakse

Biostatistisk afdeling

2 Citationer (Scopus)

Abstract

Introduction and hypothesis: Obstetric anal sphincter injury causes anal incontinence in half of the women affected. However, most symptoms are mild. The objective of this study was to evaluate the prevalence of anal incontinence and quality of life in women at long term after delivery with obstetric anal sphincter injury. We also wanted to identify a relevant cutoff level of the Wexner score (also known as the Cleveland Clinic Incontinence Score) to indicate affected quality of life in these women. Methods: We performed a population-based questionnaire cohort study with prospective follow-up, including all women in Denmark with obstetric anal sphincter injury and one subsequent delivery between 1997 and 2005. We performed uni- and multivariate analyses and calculated the area under the ROC curve. Results: In Denmark, 3885 women had an obstetric anal sphincter injury in their first delivery and a second delivery between 1997 and 2005 and no subsequent deliveries until 2010–2011. Questionnaires were sent to 3259 eligible women, and the response rate was 74.6%. In total, 2004 women could be included in the final analyses. Of these, 29.2% (n = 584) reported affected quality of life due to anal incontinence at long-term follow-up. We found that all symptoms of anal incontinence were associated with affected quality of life. The median age at follow-up was 40.3 years. The area under the ROC curve was 0.96 (95% CI 0.95–0.97) with a sensitivity of 0.94 (95% CI 0.92–0.96) and a specificity of 0.85 (95% CI 0.84–0.87) corresponding to an optimal cutoff level of the Wexner score of ≥ 2 to identify women with affected quality of life due to anal incontinence. Conclusions: In women with obstetric anal sphincter injury, 29% reported affected quality of life due to anal incontinence at long-term follow-up, and we found a low Wexner score cutoff level of ≥ 2 to identify women with affected quality of life.

Originalsprog	Engelsk
Tidsskrift	International Urogynecology Journal
ISSN	0937-3462
DOI	https://doi.org/10.1007/s00192-019-04134-1
Status	Udgivet - 1 jun. 2020

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10.1007/s00192-019-04134-1

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@article{cb7a64c4e631487fa1d8e0c1c620011d,

title = "Wexner score and quality of life in women with obstetric anal sphincter injury",

abstract = "Introduction and hypothesis: Obstetric anal sphincter injury causes anal incontinence in half of the women affected. However, most symptoms are mild. The objective of this study was to evaluate the prevalence of anal incontinence and quality of life in women at long term after delivery with obstetric anal sphincter injury. We also wanted to identify a relevant cutoff level of the Wexner score (also known as the Cleveland Clinic Incontinence Score) to indicate affected quality of life in these women. Methods: We performed a population-based questionnaire cohort study with prospective follow-up, including all women in Denmark with obstetric anal sphincter injury and one subsequent delivery between 1997 and 2005. We performed uni- and multivariate analyses and calculated the area under the ROC curve. Results: In Denmark, 3885 women had an obstetric anal sphincter injury in their first delivery and a second delivery between 1997 and 2005 and no subsequent deliveries until 2010–2011. Questionnaires were sent to 3259 eligible women, and the response rate was 74.6%. In total, 2004 women could be included in the final analyses. Of these, 29.2% (n = 584) reported affected quality of life due to anal incontinence at long-term follow-up. We found that all symptoms of anal incontinence were associated with affected quality of life. The median age at follow-up was 40.3 years. The area under the ROC curve was 0.96 (95% CI 0.95–0.97) with a sensitivity of 0.94 (95% CI 0.92–0.96) and a specificity of 0.85 (95% CI 0.84–0.87) corresponding to an optimal cutoff level of the Wexner score of ≥ 2 to identify women with affected quality of life due to anal incontinence. Conclusions: In women with obstetric anal sphincter injury, 29% reported affected quality of life due to anal incontinence at long-term follow-up, and we found a low Wexner score cutoff level of ≥ 2 to identify women with affected quality of life.",

keywords = "Cleveland Clinic Incontinence Score, Fecal incontinence, Obstetric anal sphincter injury, Quality of life, Questionnaire, Wexner score",

author = "Hanna Jango and Jens Langhoff-Roos and Susanne Rosthoj and Abelone Sakse",

year = "2020",

month = jun,

day = "1",

doi = "10.1007/s00192-019-04134-1",

language = "English",

journal = "International Urogynecology Journal",

issn = "0937-3462",

publisher = "Springer",

}

TY - JOUR

T1 - Wexner score and quality of life in women with obstetric anal sphincter injury

AU - Jango, Hanna

AU - Langhoff-Roos, Jens

AU - Rosthoj, Susanne

AU - Sakse, Abelone

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Introduction and hypothesis: Obstetric anal sphincter injury causes anal incontinence in half of the women affected. However, most symptoms are mild. The objective of this study was to evaluate the prevalence of anal incontinence and quality of life in women at long term after delivery with obstetric anal sphincter injury. We also wanted to identify a relevant cutoff level of the Wexner score (also known as the Cleveland Clinic Incontinence Score) to indicate affected quality of life in these women. Methods: We performed a population-based questionnaire cohort study with prospective follow-up, including all women in Denmark with obstetric anal sphincter injury and one subsequent delivery between 1997 and 2005. We performed uni- and multivariate analyses and calculated the area under the ROC curve. Results: In Denmark, 3885 women had an obstetric anal sphincter injury in their first delivery and a second delivery between 1997 and 2005 and no subsequent deliveries until 2010–2011. Questionnaires were sent to 3259 eligible women, and the response rate was 74.6%. In total, 2004 women could be included in the final analyses. Of these, 29.2% (n = 584) reported affected quality of life due to anal incontinence at long-term follow-up. We found that all symptoms of anal incontinence were associated with affected quality of life. The median age at follow-up was 40.3 years. The area under the ROC curve was 0.96 (95% CI 0.95–0.97) with a sensitivity of 0.94 (95% CI 0.92–0.96) and a specificity of 0.85 (95% CI 0.84–0.87) corresponding to an optimal cutoff level of the Wexner score of ≥ 2 to identify women with affected quality of life due to anal incontinence. Conclusions: In women with obstetric anal sphincter injury, 29% reported affected quality of life due to anal incontinence at long-term follow-up, and we found a low Wexner score cutoff level of ≥ 2 to identify women with affected quality of life.

AB - Introduction and hypothesis: Obstetric anal sphincter injury causes anal incontinence in half of the women affected. However, most symptoms are mild. The objective of this study was to evaluate the prevalence of anal incontinence and quality of life in women at long term after delivery with obstetric anal sphincter injury. We also wanted to identify a relevant cutoff level of the Wexner score (also known as the Cleveland Clinic Incontinence Score) to indicate affected quality of life in these women. Methods: We performed a population-based questionnaire cohort study with prospective follow-up, including all women in Denmark with obstetric anal sphincter injury and one subsequent delivery between 1997 and 2005. We performed uni- and multivariate analyses and calculated the area under the ROC curve. Results: In Denmark, 3885 women had an obstetric anal sphincter injury in their first delivery and a second delivery between 1997 and 2005 and no subsequent deliveries until 2010–2011. Questionnaires were sent to 3259 eligible women, and the response rate was 74.6%. In total, 2004 women could be included in the final analyses. Of these, 29.2% (n = 584) reported affected quality of life due to anal incontinence at long-term follow-up. We found that all symptoms of anal incontinence were associated with affected quality of life. The median age at follow-up was 40.3 years. The area under the ROC curve was 0.96 (95% CI 0.95–0.97) with a sensitivity of 0.94 (95% CI 0.92–0.96) and a specificity of 0.85 (95% CI 0.84–0.87) corresponding to an optimal cutoff level of the Wexner score of ≥ 2 to identify women with affected quality of life due to anal incontinence. Conclusions: In women with obstetric anal sphincter injury, 29% reported affected quality of life due to anal incontinence at long-term follow-up, and we found a low Wexner score cutoff level of ≥ 2 to identify women with affected quality of life.

KW - Cleveland Clinic Incontinence Score

KW - Fecal incontinence

KW - Obstetric anal sphincter injury

KW - Quality of life

KW - Questionnaire

KW - Wexner score

U2 - 10.1007/s00192-019-04134-1

DO - 10.1007/s00192-019-04134-1

M3 - Journal article

C2 - 31792591

SN - 0937-3462

JO - International Urogynecology Journal

JF - International Urogynecology Journal

ER -

Wexner score and quality of life in women with obstetric anal sphincter injury

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