Weight loss is superior to exercise in improving the atherogenic lipid profile in a sedentary, overweight population with stable coronary artery disease: A randomized trial

Lene Rørholm Pedersen; Rasmus Huan Olsen; Christian Anholm; Rosemary L Walzem; Mogens Fenger; Jesper Eugen-Olsen; Steen Bendix Haugaard; Eva Prescott

doi:10.1016/j.atherosclerosis.2016.01.001

Weight loss is superior to exercise in improving the atherogenic lipid profile in a sedentary, overweight population with stable coronary artery disease: A randomized trial

Lene Rørholm Pedersen, Rasmus Huan Olsen, Christian Anholm, Rosemary L Walzem, Mogens Fenger, Jesper Eugen-Olsen, Steen Bendix Haugaard, Eva Prescott

Institut for Klinisk Medicin

19 Citationer (Scopus)

Abstract

Background: Dyslipidemia and low-grade inflammation are integral in the pathogenesis of atherosclerosis. We aim to compare the effects of a considerable weight loss and intensive exercise training on lipid atherogenicity and low-grade inflammation in a high-risk population with coronary artery disease (CAD). Methods: Seventy non-diabetic participants with CAD, BMI 28-40 kg/m², age 45-75 years were randomized to 12 weeks' aerobic interval training (AIT) at 85-90% of peak heart rate three times/week or a low energy diet (LED, 800-1000 kcal/day) for 8-10 weeks followed by 2-4 weeks' weight maintenance diet. Lipid profile atherogenicity was described using lipoprotein particle size and density profiling. Low-grade inflammation was evaluated by tumor necrosis factor alpha (TNFα), C-reactive protein, interleukin 6 and soluble urokinase plasminogen activator receptor. Results: Twenty-six (74%) AIT and 29 (83%) LED participants completed intervention per protocol. AIT and LED decreased total (AIT: -518 (906;-129),P = 0.011, LED: -767 (-1128:-406),P < 0.001) and low-density lipoprotein (LDL, AIT: -186 (-306;-65),P = 0.004, LED: -277 (-433;-122),P < 0.001) assessed as the area under the density profile curve. LED was superior to AIT in decreasing atherogenicity reflected by increased LDL (between-group: 1.0 Å (0.4; 1.7),P = 0.003) and high-density lipoprotein (between-group: 1.2 Å (0.2; 2.4),P = 0.026) particle size and a decreased proportion of total lipoprotein constituted by the small, dense LDL₅ subfraction (between-group: -5.0% (-8.4;-1.7),P = 0.004). LED decreased TNFα (9.5% (-15.8;-2.6),P = 0.009). No changes were seen following AIT. Conclusion: LED and AIT decreased total and LDL lipoprotein. LED was superior in decreasing atherogenicity assessed by a shift in density profile and increased particle size. Effect on low-grade inflammation was limited.

Originalsprog	Engelsk
Tidsskrift	Atherosclerosis
Vol/bind	246
Sider (fra-til)	221-8
Antal sider	8
ISSN	0021-9150
DOI	https://doi.org/10.1016/j.atherosclerosis.2016.01.001
Status	Udgivet - 1 mar. 2016

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10.1016/j.atherosclerosis.2016.01.001

Citationsformater

Pedersen, L. R., Olsen, R. H., Anholm, C., Walzem, R. L., Fenger, M., Eugen-Olsen, J., Haugaard, S. B., & Prescott, E. (2016). Weight loss is superior to exercise in improving the atherogenic lipid profile in a sedentary, overweight population with stable coronary artery disease: A randomized trial. Atherosclerosis, 246, 221-8. https://doi.org/10.1016/j.atherosclerosis.2016.01.001

Weight loss is superior to exercise in improving the atherogenic lipid profile in a sedentary, overweight population with stable coronary artery disease : A randomized trial. / Pedersen, Lene Rørholm; Olsen, Rasmus Huan; Anholm, Christian et al.

I: Atherosclerosis, Bind 246, 01.03.2016, s. 221-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Pedersen, LR, Olsen, RH, Anholm, C, Walzem, RL, Fenger, M, Eugen-Olsen, J, Haugaard, SB & Prescott, E 2016, 'Weight loss is superior to exercise in improving the atherogenic lipid profile in a sedentary, overweight population with stable coronary artery disease: A randomized trial', Atherosclerosis, bind 246, s. 221-8. https://doi.org/10.1016/j.atherosclerosis.2016.01.001

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title = "Weight loss is superior to exercise in improving the atherogenic lipid profile in a sedentary, overweight population with stable coronary artery disease: A randomized trial",

abstract = "Background: Dyslipidemia and low-grade inflammation are integral in the pathogenesis of atherosclerosis. We aim to compare the effects of a considerable weight loss and intensive exercise training on lipid atherogenicity and low-grade inflammation in a high-risk population with coronary artery disease (CAD). Methods: Seventy non-diabetic participants with CAD, BMI 28-40 kg/m2, age 45-75 years were randomized to 12 weeks' aerobic interval training (AIT) at 85-90% of peak heart rate three times/week or a low energy diet (LED, 800-1000 kcal/day) for 8-10 weeks followed by 2-4 weeks' weight maintenance diet. Lipid profile atherogenicity was described using lipoprotein particle size and density profiling. Low-grade inflammation was evaluated by tumor necrosis factor alpha (TNFα), C-reactive protein, interleukin 6 and soluble urokinase plasminogen activator receptor. Results: Twenty-six (74%) AIT and 29 (83%) LED participants completed intervention per protocol. AIT and LED decreased total (AIT: -518 (906;-129),P = 0.011, LED: -767 (-1128:-406),P < 0.001) and low-density lipoprotein (LDL, AIT: -186 (-306;-65),P = 0.004, LED: -277 (-433;-122),P < 0.001) assessed as the area under the density profile curve. LED was superior to AIT in decreasing atherogenicity reflected by increased LDL (between-group: 1.0 {\AA} (0.4; 1.7),P = 0.003) and high-density lipoprotein (between-group: 1.2 {\AA} (0.2; 2.4),P = 0.026) particle size and a decreased proportion of total lipoprotein constituted by the small, dense LDL5 subfraction (between-group: -5.0% (-8.4;-1.7),P = 0.004). LED decreased TNFα (9.5% (-15.8;-2.6),P = 0.009). No changes were seen following AIT. Conclusion: LED and AIT decreased total and LDL lipoprotein. LED was superior in decreasing atherogenicity assessed by a shift in density profile and increased particle size. Effect on low-grade inflammation was limited.",

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author = "Pedersen, {Lene R{\o}rholm} and Olsen, {Rasmus Huan} and Christian Anholm and Walzem, {Rosemary L} and Mogens Fenger and Jesper Eugen-Olsen and Haugaard, {Steen Bendix} and Eva Prescott",

year = "2016",

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doi = "10.1016/j.atherosclerosis.2016.01.001",

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TY - JOUR

T1 - Weight loss is superior to exercise in improving the atherogenic lipid profile in a sedentary, overweight population with stable coronary artery disease

T2 - A randomized trial

AU - Pedersen, Lene Rørholm

AU - Olsen, Rasmus Huan

AU - Anholm, Christian

AU - Walzem, Rosemary L

AU - Fenger, Mogens

AU - Eugen-Olsen, Jesper

AU - Haugaard, Steen Bendix

AU - Prescott, Eva

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Background: Dyslipidemia and low-grade inflammation are integral in the pathogenesis of atherosclerosis. We aim to compare the effects of a considerable weight loss and intensive exercise training on lipid atherogenicity and low-grade inflammation in a high-risk population with coronary artery disease (CAD). Methods: Seventy non-diabetic participants with CAD, BMI 28-40 kg/m2, age 45-75 years were randomized to 12 weeks' aerobic interval training (AIT) at 85-90% of peak heart rate three times/week or a low energy diet (LED, 800-1000 kcal/day) for 8-10 weeks followed by 2-4 weeks' weight maintenance diet. Lipid profile atherogenicity was described using lipoprotein particle size and density profiling. Low-grade inflammation was evaluated by tumor necrosis factor alpha (TNFα), C-reactive protein, interleukin 6 and soluble urokinase plasminogen activator receptor. Results: Twenty-six (74%) AIT and 29 (83%) LED participants completed intervention per protocol. AIT and LED decreased total (AIT: -518 (906;-129),P = 0.011, LED: -767 (-1128:-406),P < 0.001) and low-density lipoprotein (LDL, AIT: -186 (-306;-65),P = 0.004, LED: -277 (-433;-122),P < 0.001) assessed as the area under the density profile curve. LED was superior to AIT in decreasing atherogenicity reflected by increased LDL (between-group: 1.0 Å (0.4; 1.7),P = 0.003) and high-density lipoprotein (between-group: 1.2 Å (0.2; 2.4),P = 0.026) particle size and a decreased proportion of total lipoprotein constituted by the small, dense LDL5 subfraction (between-group: -5.0% (-8.4;-1.7),P = 0.004). LED decreased TNFα (9.5% (-15.8;-2.6),P = 0.009). No changes were seen following AIT. Conclusion: LED and AIT decreased total and LDL lipoprotein. LED was superior in decreasing atherogenicity assessed by a shift in density profile and increased particle size. Effect on low-grade inflammation was limited.

AB - Background: Dyslipidemia and low-grade inflammation are integral in the pathogenesis of atherosclerosis. We aim to compare the effects of a considerable weight loss and intensive exercise training on lipid atherogenicity and low-grade inflammation in a high-risk population with coronary artery disease (CAD). Methods: Seventy non-diabetic participants with CAD, BMI 28-40 kg/m2, age 45-75 years were randomized to 12 weeks' aerobic interval training (AIT) at 85-90% of peak heart rate three times/week or a low energy diet (LED, 800-1000 kcal/day) for 8-10 weeks followed by 2-4 weeks' weight maintenance diet. Lipid profile atherogenicity was described using lipoprotein particle size and density profiling. Low-grade inflammation was evaluated by tumor necrosis factor alpha (TNFα), C-reactive protein, interleukin 6 and soluble urokinase plasminogen activator receptor. Results: Twenty-six (74%) AIT and 29 (83%) LED participants completed intervention per protocol. AIT and LED decreased total (AIT: -518 (906;-129),P = 0.011, LED: -767 (-1128:-406),P < 0.001) and low-density lipoprotein (LDL, AIT: -186 (-306;-65),P = 0.004, LED: -277 (-433;-122),P < 0.001) assessed as the area under the density profile curve. LED was superior to AIT in decreasing atherogenicity reflected by increased LDL (between-group: 1.0 Å (0.4; 1.7),P = 0.003) and high-density lipoprotein (between-group: 1.2 Å (0.2; 2.4),P = 0.026) particle size and a decreased proportion of total lipoprotein constituted by the small, dense LDL5 subfraction (between-group: -5.0% (-8.4;-1.7),P = 0.004). LED decreased TNFα (9.5% (-15.8;-2.6),P = 0.009). No changes were seen following AIT. Conclusion: LED and AIT decreased total and LDL lipoprotein. LED was superior in decreasing atherogenicity assessed by a shift in density profile and increased particle size. Effect on low-grade inflammation was limited.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.atherosclerosis.2016.01.001

DO - 10.1016/j.atherosclerosis.2016.01.001

M3 - Journal article

C2 - 26803431

SN - 0021-9150

VL - 246

SP - 221

EP - 228

JO - Atherosclerosis

JF - Atherosclerosis

ER -

Weight loss is superior to exercise in improving the atherogenic lipid profile in a sedentary, overweight population with stable coronary artery disease: A randomized trial

Abstract

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