Weekday variation in triglyceride concentrations in 1.8 million blood samples

TY - JOUR

T1 - Weekday variation in triglyceride concentrations in 1.8 million blood samples

AU - Jaskolowski, Jörn

AU - Ritz, Christian

AU - Sjödin, Anders Mikael

AU - Astrup, Arne

AU - Szecsi, Pal Bela

AU - Stender, Steen

AU - Hjorth, Mads Fiil

N1 - CURIS 2017 NEXS 157

PY - 2017/6

Y1 - 2017/6

N2 - Triglyceride (TG) concentration is used as a marker of cardiometabolic risk. However, diurnal and possibly weekday variation exists in TG concentrations. The objective of this work was to investigate weekday variation in TG concentrations among 1.8 million blood samples drawn between 2008 and 2015 from patients in the Capital region of Denmark. Plasma TG was extracted from a central clinical laboratory information system. Weekday variation was investigated by means of linear mixed models. In addition to the profound diurnal variation, the TG concentration was 4.5% lower on Fridays compared with Mondays (P < 0.0001). The variation persisted after multiple adjustments for confound-ers and was consistent across all sensitivity analyses. Outpatients and in-patients, respectively, had 5.0% and 1.9% lower TG concentrations on Fridays compared with Mondays (both P < 0.0001). The highest weekday variations in TG concentrations were recorded for out-patients between the ages of 9 and 26 years, with up to 20% higher values on Mondays compared with Fridays (all P < 0.05). In conclusion, TG concentrations were highest after the weekend and gradually declined during the week. We suggest that unhealthy food intake and reduced physical activity during the weekend increase TG concentrations which track into the week. This weekday variation may carry implications for public lion blood samples.

AB - Triglyceride (TG) concentration is used as a marker of cardiometabolic risk. However, diurnal and possibly weekday variation exists in TG concentrations. The objective of this work was to investigate weekday variation in TG concentrations among 1.8 million blood samples drawn between 2008 and 2015 from patients in the Capital region of Denmark. Plasma TG was extracted from a central clinical laboratory information system. Weekday variation was investigated by means of linear mixed models. In addition to the profound diurnal variation, the TG concentration was 4.5% lower on Fridays compared with Mondays (P < 0.0001). The variation persisted after multiple adjustments for confound-ers and was consistent across all sensitivity analyses. Outpatients and in-patients, respectively, had 5.0% and 1.9% lower TG concentrations on Fridays compared with Mondays (both P < 0.0001). The highest weekday variations in TG concentrations were recorded for out-patients between the ages of 9 and 26 years, with up to 20% higher values on Mondays compared with Fridays (all P < 0.05). In conclusion, TG concentrations were highest after the weekend and gradually declined during the week. We suggest that unhealthy food intake and reduced physical activity during the weekend increase TG concentrations which track into the week. This weekday variation may carry implications for public lion blood samples.

KW - Diet and dietary lipids

KW - Lipid biochemistry

KW - Nutrition/Lipids

KW - Nutrition/Carbohydrates

KW - Triglycerides

KW - Patients

KW - Weekday differences

KW - Samples

U2 - 10.1194/jlr.m074062

DO - 10.1194/jlr.m074062

M3 - Journal article

C2 - 28381440

SN - 0022-2275

VL - 58

SP - 1204

EP - 1213

JO - Journal of Lipid Research

JF - Journal of Lipid Research

IS - 6

ER -