Voluntary ingestion of nut paste for administration of buprenorphine in rats and mice

TY - JOUR

T1 - Voluntary ingestion of nut paste for administration of buprenorphine in rats and mice

AU - Abelson, Klas S P

AU - Jacobsen, Kirsten R

AU - Sundbom, Renée

AU - Kalliokoski, Otto

AU - Hau, Jann

PY - 2012

Y1 - 2012

N2 - An adequate analgesic strategy is important to improve the postoperative recovery and welfare of laboratory rats and mice. It is desirable that the method for administering the drug is non-invasive and stress-free. We have previously validated a method for administering buprenorphine in a nut paste for voluntary ingestion. This method has many advantages over parenteral administration. To use the method in a successful way, however, it is important to prepare and administer the mix correctly. The present paper describes in detail how to implement the method, by means of habituation, presentation, adequate concentrations and amounts of buprenorphine/nut paste, and dosage of buprenorphine to rats and mice.

AB - An adequate analgesic strategy is important to improve the postoperative recovery and welfare of laboratory rats and mice. It is desirable that the method for administering the drug is non-invasive and stress-free. We have previously validated a method for administering buprenorphine in a nut paste for voluntary ingestion. This method has many advantages over parenteral administration. To use the method in a successful way, however, it is important to prepare and administer the mix correctly. The present paper describes in detail how to implement the method, by means of habituation, presentation, adequate concentrations and amounts of buprenorphine/nut paste, and dosage of buprenorphine to rats and mice.

U2 - 10.1258/la.2012.012028

DO - 10.1258/la.2012.012028

M3 - Journal article

C2 - 22969145

SN - 0023-6772

VL - 46

SP - 349

EP - 351

JO - Laboratory Animals

JF - Laboratory Animals

IS - 4

ER -