Visual attention in 7-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish high risk and resilience study VIA 7

Nicoline Hemager; Signe Vangkilde; Anne Amalie Elgaard Thorup; Camilla Christiani; Ditte Ellersgaard; Katrine Soborg Spang; Birgitte Klee Burton; Aja Neergaard Greve; Ditte Lou Gantriis; Ole Mors; Jens Richardt Mollegaard Jepsen; Merete Nordentoft; Kerstin Jessica Plessen

doi:10.1016/j.jad.2019.07.079

Visual attention in 7-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish high risk and resilience study VIA 7

Nicoline Hemager, Signe Vangkilde, Anne Amalie Elgaard Thorup, Camilla Christiani, Ditte Ellersgaard, Katrine Soborg Spang, Birgitte Klee Burton, Aja Neergaard Greve, Ditte Lou Gantriis, Ole Mors, Jens Richardt Mollegaard Jepsen, Merete Nordentoft, Kerstin Jessica Plessen

Institut for Klinisk Medicin

4 Citationer (Scopus)

Abstract

Background: Attention deficits are found in children at familial high risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP) using assessment methods relying on motor-based response latency. This study compares visual attention functions in children at FHR-SZ or FHR-BP with controls using an unspeeded task unconfounded by motor components. Methods: Visual attention was assessed in 133 7-year-old children at FHR-SZ (N = 56) or FHR-BP (N = 32), and controls (N = 45) using the unspeeded paradigm, TVA-based whole report. We compared four parameters of visual attention: visual processing speed, visual short-term memory, threshold for visual perception, and error rate. Further, we investigated their potential relationships with severity of psychopathology, adequacy of the home environment, and neurocognitive measures. Results: Children at FHR-SZ displayed significant deficits in perceptual processing speed of visual attention compared with controls (p <.001; d = 0.75) as did children at FHR-BP (p <.05; d = 0.54). Visual processing speed was significantly associated with spatial working memory (β = -0.23; t(68) = -3.34, p =.01) and psychomotor processing speed (β = 0.14, t(67) = 2.11, p <.05). Limitations: Larger group sizes would have permitted inclusion of more predictors in the search for neurocognitive and other factors associated with the parameters of TVA-based whole report. Conclusions: Young children at FHR-SZ and FHR-BP display significant deficits in processing speed of visual attention, which may reflect the effect of shared vulnerability risk genes. Early identification of children at FHR-SZ and FHR-BP with perceptual processing speed impairments may represent a low-cost basis for low-risk interventions.

Originalsprog	Engelsk
Tidsskrift	Journal of Affective Disorders
Vol/bind	258
Sider (fra-til)	56-65
ISSN	0165-0327
DOI	https://doi.org/10.1016/j.jad.2019.07.079
Status	Udgivet - 1 nov. 2019

Adgang til dokumentet

10.1016/j.jad.2019.07.079

Citationsformater

Hemager, N., Vangkilde, S., Thorup, A. A. E., Christiani, C., Ellersgaard, D., Spang, K. S., Burton, B. K., Greve, A. N., Gantriis, D. L., Mors, O., Jepsen, J. R. M., Nordentoft, M., & Plessen, K. J. (2019). Visual attention in 7-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish high risk and resilience study VIA 7. Journal of Affective Disorders, 258, 56-65. https://doi.org/10.1016/j.jad.2019.07.079

Visual attention in 7-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish high risk and resilience study VIA 7. / Hemager, Nicoline; Vangkilde, Signe ; Thorup, Anne Amalie Elgaard et al.

I: Journal of Affective Disorders, Bind 258, 01.11.2019, s. 56-65.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Hemager, N, Vangkilde, S , Thorup, AAE, Christiani, C, Ellersgaard, D, Spang, KS, Burton, BK, Greve, AN, Gantriis, DL, Mors, O, Jepsen, JRM, Nordentoft, M & Plessen, KJ 2019, 'Visual attention in 7-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish high risk and resilience study VIA 7', Journal of Affective Disorders, bind 258, s. 56-65. https://doi.org/10.1016/j.jad.2019.07.079

@article{8439251afc1e4245bc40705aa003b30c,

title = "Visual attention in 7-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish high risk and resilience study VIA 7",

abstract = "Background: Attention deficits are found in children at familial high risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP) using assessment methods relying on motor-based response latency. This study compares visual attention functions in children at FHR-SZ or FHR-BP with controls using an unspeeded task unconfounded by motor components. Methods: Visual attention was assessed in 133 7-year-old children at FHR-SZ (N = 56) or FHR-BP (N = 32), and controls (N = 45) using the unspeeded paradigm, TVA-based whole report. We compared four parameters of visual attention: visual processing speed, visual short-term memory, threshold for visual perception, and error rate. Further, we investigated their potential relationships with severity of psychopathology, adequacy of the home environment, and neurocognitive measures. Results: Children at FHR-SZ displayed significant deficits in perceptual processing speed of visual attention compared with controls (p <.001; d = 0.75) as did children at FHR-BP (p <.05; d = 0.54). Visual processing speed was significantly associated with spatial working memory (β = -0.23; t(68) = -3.34, p =.01) and psychomotor processing speed (β = 0.14, t(67) = 2.11, p <.05). Limitations: Larger group sizes would have permitted inclusion of more predictors in the search for neurocognitive and other factors associated with the parameters of TVA-based whole report. Conclusions: Young children at FHR-SZ and FHR-BP display significant deficits in processing speed of visual attention, which may reflect the effect of shared vulnerability risk genes. Early identification of children at FHR-SZ and FHR-BP with perceptual processing speed impairments may represent a low-cost basis for low-risk interventions.",

keywords = "Bipolar disorder, Schizophrenia, Familial high risk, Visual attention",

author = "Nicoline Hemager and Signe Vangkilde and Thorup, {Anne Amalie Elgaard} and Camilla Christiani and Ditte Ellersgaard and Spang, {Katrine Soborg} and Burton, {Birgitte Klee} and Greve, {Aja Neergaard} and Gantriis, {Ditte Lou} and Ole Mors and Jepsen, {Jens Richardt Mollegaard} and Merete Nordentoft and Plessen, {Kerstin Jessica}",

year = "2019",

month = nov,

day = "1",

doi = "10.1016/j.jad.2019.07.079",

language = "English",

volume = "258",

pages = "56--65",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

publisher = "Elsevier",

}

TY - JOUR

T1 - Visual attention in 7-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish high risk and resilience study VIA 7

AU - Hemager, Nicoline

AU - Vangkilde, Signe

AU - Thorup, Anne Amalie Elgaard

AU - Christiani, Camilla

AU - Ellersgaard, Ditte

AU - Spang, Katrine Soborg

AU - Burton, Birgitte Klee

AU - Greve, Aja Neergaard

AU - Gantriis, Ditte Lou

AU - Mors, Ole

AU - Jepsen, Jens Richardt Mollegaard

AU - Nordentoft, Merete

AU - Plessen, Kerstin Jessica

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Background: Attention deficits are found in children at familial high risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP) using assessment methods relying on motor-based response latency. This study compares visual attention functions in children at FHR-SZ or FHR-BP with controls using an unspeeded task unconfounded by motor components. Methods: Visual attention was assessed in 133 7-year-old children at FHR-SZ (N = 56) or FHR-BP (N = 32), and controls (N = 45) using the unspeeded paradigm, TVA-based whole report. We compared four parameters of visual attention: visual processing speed, visual short-term memory, threshold for visual perception, and error rate. Further, we investigated their potential relationships with severity of psychopathology, adequacy of the home environment, and neurocognitive measures. Results: Children at FHR-SZ displayed significant deficits in perceptual processing speed of visual attention compared with controls (p <.001; d = 0.75) as did children at FHR-BP (p <.05; d = 0.54). Visual processing speed was significantly associated with spatial working memory (β = -0.23; t(68) = -3.34, p =.01) and psychomotor processing speed (β = 0.14, t(67) = 2.11, p <.05). Limitations: Larger group sizes would have permitted inclusion of more predictors in the search for neurocognitive and other factors associated with the parameters of TVA-based whole report. Conclusions: Young children at FHR-SZ and FHR-BP display significant deficits in processing speed of visual attention, which may reflect the effect of shared vulnerability risk genes. Early identification of children at FHR-SZ and FHR-BP with perceptual processing speed impairments may represent a low-cost basis for low-risk interventions.

AB - Background: Attention deficits are found in children at familial high risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP) using assessment methods relying on motor-based response latency. This study compares visual attention functions in children at FHR-SZ or FHR-BP with controls using an unspeeded task unconfounded by motor components. Methods: Visual attention was assessed in 133 7-year-old children at FHR-SZ (N = 56) or FHR-BP (N = 32), and controls (N = 45) using the unspeeded paradigm, TVA-based whole report. We compared four parameters of visual attention: visual processing speed, visual short-term memory, threshold for visual perception, and error rate. Further, we investigated their potential relationships with severity of psychopathology, adequacy of the home environment, and neurocognitive measures. Results: Children at FHR-SZ displayed significant deficits in perceptual processing speed of visual attention compared with controls (p <.001; d = 0.75) as did children at FHR-BP (p <.05; d = 0.54). Visual processing speed was significantly associated with spatial working memory (β = -0.23; t(68) = -3.34, p =.01) and psychomotor processing speed (β = 0.14, t(67) = 2.11, p <.05). Limitations: Larger group sizes would have permitted inclusion of more predictors in the search for neurocognitive and other factors associated with the parameters of TVA-based whole report. Conclusions: Young children at FHR-SZ and FHR-BP display significant deficits in processing speed of visual attention, which may reflect the effect of shared vulnerability risk genes. Early identification of children at FHR-SZ and FHR-BP with perceptual processing speed impairments may represent a low-cost basis for low-risk interventions.

KW - Bipolar disorder

KW - Schizophrenia

KW - Familial high risk

KW - Visual attention

U2 - 10.1016/j.jad.2019.07.079

DO - 10.1016/j.jad.2019.07.079

M3 - Journal article

C2 - 31394459

SN - 0165-0327

VL - 258

SP - 56

EP - 65

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

ER -

Visual attention in 7-year-old children at familial high risk of schizophrenia or bipolar disorder: The Danish high risk and resilience study VIA 7

Abstract

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