Virulence of a Klebsiella pneumoniae strain carrying the New Delhi metallo-beta-lactamase-1 (NDM-1)

TY - JOUR

T1 - Virulence of a Klebsiella pneumoniae strain carrying the New Delhi metallo-beta-lactamase-1 (NDM-1)

AU - Fuursted, K

AU - Schøler, L

AU - Hansen, F

AU - Dam, K

AU - Bojer, Martin Saxtorph

AU - Hammerum, AM

AU - F, Dagnæs-Hansen

AU - Olsen, A

AU - Jasemian, Y

AU - Struve, C

PY - 2012/2

Y1 - 2012/2

N2 - The aim of the study was to compare and evaluate virulence in five strains of Klebsiella pneumoniae, including an isolate carrying New Delhi metallo-beta-lactamase-1 (NDM-1). Invivo virulence was assessed using a murine sepsis model and using the nematode Caenorhabditis elegans killing model, and invitro virulence by assessing various virulence factors. The NDM-1 carrying K. pneumoniae isolate was the most virulent in the murine sepsis model but there was no clear cut correlation to invitro virulence factors or killing in C. elegans. It is concluded that K. pneumoniae carrying NDM-1 have an intrinsic virulence potential, which in coexistence with its multiresistance could promote and partly explain its epidemiological success.

AB - The aim of the study was to compare and evaluate virulence in five strains of Klebsiella pneumoniae, including an isolate carrying New Delhi metallo-beta-lactamase-1 (NDM-1). Invivo virulence was assessed using a murine sepsis model and using the nematode Caenorhabditis elegans killing model, and invitro virulence by assessing various virulence factors. The NDM-1 carrying K. pneumoniae isolate was the most virulent in the murine sepsis model but there was no clear cut correlation to invitro virulence factors or killing in C. elegans. It is concluded that K. pneumoniae carrying NDM-1 have an intrinsic virulence potential, which in coexistence with its multiresistance could promote and partly explain its epidemiological success.

M3 - Journal article

SN - 1286-4579

JO - Microbes and Infection

JF - Microbes and Infection

ER -