Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR)

Keld Danoe,; Francesco Blasi; Louring Roldan, Ann; Vittoria Cubellis, Maria; Teresa Masucci, Maria; Ettore Appella,; Wolf-Dieter Schleuning,; Niels Behrendt,; Ebbe Rønne; Peter Kristensen,; Jari Pollanen,; Eeva-Marjatta Salonen,; W Stephens, Ross; Hannele Tapiovaara,; Antti Vaheri,; Birk Moeller, Lisbeth; Vincent Ellis,; Roege Lund, Leif; Michael Ploug,; Charles Pyke; Laszlo Patthy

Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR)

Keld Danoe, (Opfinder), Francesco Blasi (Opfinder), Louring Roldan, Ann (Opfinder), Vittoria Cubellis, Maria (Opfinder), Teresa Masucci, Maria (Opfinder), Ettore Appella, (Opfinder), Wolf-Dieter Schleuning, (Opfinder), Niels Behrendt, (Opfinder), Ebbe Rønne (Opfinder), Peter Kristensen, (Opfinder), Jari Pollanen, (Opfinder), Eeva-Marjatta Salonen, (Opfinder), W Stephens, Ross (Opfinder), Hannele Tapiovaara, (Opfinder), Antti Vaheri, (Opfinder), Birk Moeller, Lisbeth (Opfinder), Vincent Ellis, (Opfinder), Roege Lund, Leif (Opfinder), Michael Ploug, (Opfinder), Charles Pyke (Opfinder)Laszlo Patthy (Opfinder)

Abstract

Activation of plasminogen to plasma is inhibited by preventing the binding of a receptor binding form of urokinase-type plasminogen activator to a urokinase-type plasminogen activator receptor in a mammal, thereby preventing the urokinase-type plasminogen activator from converting plasminogen into plasmin. DNA fragments which encode for soluble, active fragments of the urokinase-type plasminogen activator are provided.

Originalsprog	Engelsk
IPC	A61K 38/ 00 A N
Patentnummer	US5891664
Land/Område	Danmark
Prioritetsdato	06/10/1994
Prioritetsnummer	US19940319052
Status	Udgivet - 6 apr. 1999

Citationsformater

Danoe, K., Blasi, F., Roldan, Ann, L., Cubellis, Maria, V., Masucci, Maria, T., Appella, E., Schleuning, W-D., Behrendt, N., Rønne, E., Kristensen, P., Pollanen, J., Salonen, E-M., Stephens, Ross, W., Tapiovaara, H., Vaheri, A., Moeller, Lisbeth, B., Ellis, V., Lund, Leif, R., Ploug, M., ... Patthy, L. (1999). Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR). (Patentnummer US5891664).

Danoe, K, Blasi, F, Roldan, Ann, L, Cubellis, Maria, V, Masucci, Maria, T, Appella, E, Schleuning, W-D, Behrendt, N, Rønne, E, Kristensen, P, Pollanen, J, Salonen, E-M, Stephens, Ross, W, Tapiovaara, H, Vaheri, A, Moeller, Lisbeth, B, Ellis, V, Lund, Leif, R, Ploug, M, Pyke, C & Patthy, L apr.. 06 1999, Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR), Patentnummer US5891664.

@misc{679d5f2c0d264b85a1950c3f64a42d76,

title = "Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR)",

abstract = "Activation of plasminogen to plasma is inhibited by preventing the binding of a receptor binding form of urokinase-type plasminogen activator to a urokinase-type plasminogen activator receptor in a mammal, thereby preventing the urokinase-type plasminogen activator from converting plasminogen into plasmin. DNA fragments which encode for soluble, active fragments of the urokinase-type plasminogen activator are provided.",

author = "Keld Danoe, and Francesco Blasi and {Roldan, Ann}, Louring and {Cubellis, Maria}, Vittoria and {Masucci, Maria}, Teresa and Ettore Appella, and Wolf-Dieter Schleuning, and Niels Behrendt, and Ebbe R{\o}nne and Peter Kristensen, and Jari Pollanen, and Eeva-Marjatta Salonen, and {Stephens, Ross}, W and Hannele Tapiovaara, and Antti Vaheri, and {Moeller, Lisbeth}, Birk and Vincent Ellis, and {Lund, Leif}, Roege and Michael Ploug, and Charles Pyke and Laszlo Patthy",

year = "1999",

month = apr,

day = "6",

language = "English",

type = "Patent",

note = "US5891664; A61K 38/ 00 A N",

}

TY - PAT

T1 - Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR)

AU - Danoe,, Keld

AU - Blasi, Francesco

AU - Roldan, Ann, Louring

AU - Cubellis, Maria, Vittoria

AU - Masucci, Maria, Teresa

AU - Appella,, Ettore

AU - Schleuning,, Wolf-Dieter

AU - Behrendt,, Niels

AU - Rønne, Ebbe

AU - Kristensen,, Peter

AU - Pollanen,, Jari

AU - Salonen,, Eeva-Marjatta

AU - Stephens, Ross, W

AU - Tapiovaara,, Hannele

AU - Vaheri,, Antti

AU - Moeller, Lisbeth, Birk

AU - Ellis,, Vincent

AU - Lund, Leif, Roege

AU - Ploug,, Michael

AU - Pyke, Charles

AU - Patthy, Laszlo

PY - 1999/4/6

Y1 - 1999/4/6

N2 - Activation of plasminogen to plasma is inhibited by preventing the binding of a receptor binding form of urokinase-type plasminogen activator to a urokinase-type plasminogen activator receptor in a mammal, thereby preventing the urokinase-type plasminogen activator from converting plasminogen into plasmin. DNA fragments which encode for soluble, active fragments of the urokinase-type plasminogen activator are provided.

AB - Activation of plasminogen to plasma is inhibited by preventing the binding of a receptor binding form of urokinase-type plasminogen activator to a urokinase-type plasminogen activator receptor in a mammal, thereby preventing the urokinase-type plasminogen activator from converting plasminogen into plasmin. DNA fragments which encode for soluble, active fragments of the urokinase-type plasminogen activator are provided.

M3 - Patent

M1 - US5891664

ER -

Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR)

Abstract

Fingeraftryk

Citationsformater