Vasopressin binds to microvessels from rat hippocampus.

TY - JOUR

T1 - Vasopressin binds to microvessels from rat hippocampus.

AU - Kretzschmar, R

AU - Landgraf, R

AU - Gjedde, A

AU - Ermisch, A

PY - 1986

Y1 - 1986

N2 - Recent evidence suggests that vasopressin may influence the permeability of the endothelium of brain capillaries. We measured the binding of [125I]arginine-8-vasopressin ([125I]AVP) to microvessels isolated from different regions of the rat brain. The study revealed saturable and specific binding of [125I]AVP to microvessels isolated from hippocampus. Scatchard analysis confirmed a single class of high affinity sites with an equilibrium dissociation constant, Kd, of 3.2 nM and an apparent maximal binding capacity of 205 fmol/mg protein. No binding was observed to microvessels from neocortex and striatum.

AB - Recent evidence suggests that vasopressin may influence the permeability of the endothelium of brain capillaries. We measured the binding of [125I]arginine-8-vasopressin ([125I]AVP) to microvessels isolated from different regions of the rat brain. The study revealed saturable and specific binding of [125I]AVP to microvessels isolated from hippocampus. Scatchard analysis confirmed a single class of high affinity sites with an equilibrium dissociation constant, Kd, of 3.2 nM and an apparent maximal binding capacity of 205 fmol/mg protein. No binding was observed to microvessels from neocortex and striatum.

M3 - Journal article

C2 - 3756483

SN - 0006-8993

VL - 380

SP - 325

EP - 330

JO - Brain Research

JF - Brain Research

IS - 2

ER -