TY - BOOK
T1 - Vascular Function and Regulation of Blood Flow in Resting and Contracting Skeletal Muscle
T2 - Insight from Essential Hypertension, Aging and Physical Activity
AU - Nyberg, Michael Permin
N1 - CURIS 2013 NEXS 162
PY - 2013
Y1 - 2013
N2 - The precise matching of blood flow, oxygen delivery and metabolism is essential as it ensures that any increase in muscle work is precisely matched by increases in oxygen delivery. Therefore, understanding the control mechanisms of skeletal muscle blood flow regulation is of great biological importance. The present work provides new insight in to vasodilator interactions important for exercise hyperemia and sheds light on mechanisms important for vascular function and regulation of skeletal muscle blood flow in essential hypertension (high blood pressure) and aging and identifies mechanisms by which physical activity affects the function of the vascular network. Conclusion The vasodilators ATP and adenosine stimulate the nitric oxide and prostanoid systems in skeletal muscle. These vasodilator interactions may, at least in part, explain the central role of nitric oxide and prostanoids in the regulation of exercise hyperemia. Furthermore, blood flow to contracting leg skeletal muscles is reduced both in essential hypertension and with aging. The potential difference in vasoactive system(s) responsible for the reduction in blood flow in the two conditions is in agreement with the suggestion that no single compound can explain exercise hyperemia and indicates that any condition associated with reduced oxygen delivery needs to be investigated independently. Physical activity can attenuate or even counteract the effects of essential hypertension and aging on vascular function and exercise hyperemia.
AB - The precise matching of blood flow, oxygen delivery and metabolism is essential as it ensures that any increase in muscle work is precisely matched by increases in oxygen delivery. Therefore, understanding the control mechanisms of skeletal muscle blood flow regulation is of great biological importance. The present work provides new insight in to vasodilator interactions important for exercise hyperemia and sheds light on mechanisms important for vascular function and regulation of skeletal muscle blood flow in essential hypertension (high blood pressure) and aging and identifies mechanisms by which physical activity affects the function of the vascular network. Conclusion The vasodilators ATP and adenosine stimulate the nitric oxide and prostanoid systems in skeletal muscle. These vasodilator interactions may, at least in part, explain the central role of nitric oxide and prostanoids in the regulation of exercise hyperemia. Furthermore, blood flow to contracting leg skeletal muscles is reduced both in essential hypertension and with aging. The potential difference in vasoactive system(s) responsible for the reduction in blood flow in the two conditions is in agreement with the suggestion that no single compound can explain exercise hyperemia and indicates that any condition associated with reduced oxygen delivery needs to be investigated independently. Physical activity can attenuate or even counteract the effects of essential hypertension and aging on vascular function and exercise hyperemia.
UR - https://rex.kb.dk/primo-explore/fulldisplay?docid=KGL01009128579&context=L&vid=NUI&search_scope=KGL&tab=default_tab&lang=da_DK
M3 - Ph.D. thesis
SN - 978-87-7611-610-1
BT - Vascular Function and Regulation of Blood Flow in Resting and Contracting Skeletal Muscle
PB - Department of Nutrition, Exercise and Sports, Faculty of Sciences, University of Copenhagen
CY - Copenhagen
ER -