UV imaging for in vitro dissolution and release studies: Initial experiences

Jesper Østergaard; James Lenke; Sabrine Smedegaard Jensen; Yu Sun; Fengbin Ye

doi:10.14227/DT210414P27

UV imaging for in vitro dissolution and release studies: Initial experiences

Jesper Østergaard, James Lenke, Sabrine Smedegaard Jensen, Yu Sun, Fengbin Ye

16 Citationer (Scopus)

Abstract

UV imaging has recently been introduced as a method in drug dissolution and release testing. Spatially and temporally resolved mapping of drug concentrations in a 7 × 9 mm imaging area provides new opportunities for visualization and study of drug dissolution and release. This review describes the current instrumentation and principles of analysis. Pharmaceutical applications of UV imaging are presented, including determination of dissolution rates for drug substances, cocrystals, and nanocrystals and monitoring of solid form changes and single crystal dissolution as well as drug release and transport in hydrogels with relevance for characterization of parenteral depots. UV imaging may be of particular use when the amounts of material are sparse and detailed insights into dissolution and release processes are required, that is in solid form screening, preformulation, and early drug development.

Originalsprog	Engelsk
Tidsskrift	Dissolution Technologies
Vol/bind	21
Udgave nummer	4
Sider (fra-til)	27-38
Antal sider	12
ISSN	1521-298X
DOI	https://doi.org/10.14227/DT210414P27
Status	Udgivet - 1 nov. 2014

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10.14227/DT210414P27

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abstract = "UV imaging has recently been introduced as a method in drug dissolution and release testing. Spatially and temporally resolved mapping of drug concentrations in a 7 × 9 mm imaging area provides new opportunities for visualization and study of drug dissolution and release. This review describes the current instrumentation and principles of analysis. Pharmaceutical applications of UV imaging are presented, including determination of dissolution rates for drug substances, cocrystals, and nanocrystals and monitoring of solid form changes and single crystal dissolution as well as drug release and transport in hydrogels with relevance for characterization of parenteral depots. UV imaging may be of particular use when the amounts of material are sparse and detailed insights into dissolution and release processes are required, that is in solid form screening, preformulation, and early drug development.",

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AU - Østergaard, Jesper

AU - Lenke, James

AU - Jensen, Sabrine Smedegaard

AU - Sun, Yu

AU - Ye, Fengbin

PY - 2014/11/1

Y1 - 2014/11/1

N2 - UV imaging has recently been introduced as a method in drug dissolution and release testing. Spatially and temporally resolved mapping of drug concentrations in a 7 × 9 mm imaging area provides new opportunities for visualization and study of drug dissolution and release. This review describes the current instrumentation and principles of analysis. Pharmaceutical applications of UV imaging are presented, including determination of dissolution rates for drug substances, cocrystals, and nanocrystals and monitoring of solid form changes and single crystal dissolution as well as drug release and transport in hydrogels with relevance for characterization of parenteral depots. UV imaging may be of particular use when the amounts of material are sparse and detailed insights into dissolution and release processes are required, that is in solid form screening, preformulation, and early drug development.

AB - UV imaging has recently been introduced as a method in drug dissolution and release testing. Spatially and temporally resolved mapping of drug concentrations in a 7 × 9 mm imaging area provides new opportunities for visualization and study of drug dissolution and release. This review describes the current instrumentation and principles of analysis. Pharmaceutical applications of UV imaging are presented, including determination of dissolution rates for drug substances, cocrystals, and nanocrystals and monitoring of solid form changes and single crystal dissolution as well as drug release and transport in hydrogels with relevance for characterization of parenteral depots. UV imaging may be of particular use when the amounts of material are sparse and detailed insights into dissolution and release processes are required, that is in solid form screening, preformulation, and early drug development.

U2 - 10.14227/DT210414P27

DO - 10.14227/DT210414P27

M3 - Journal article

SN - 1521-298X

VL - 21

SP - 27

EP - 38

JO - Dissolution Technologies

JF - Dissolution Technologies

IS - 4

ER -

UV imaging for in vitro dissolution and release studies: Initial experiences

Abstract

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