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Utilization of prodrugs to enhance the transdermal absorption of morphine
J. Drustrup, A. Fullerton,
Lona Louring Christrup
, H. Bundgaard
26
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Keyphrases
Alkyl Esters
11%
Diffusion Experiment
11%
Ester Prodrug
11%
Esters
33%
Experiment in Vitro
11%
High Lipid
11%
High Water
11%
Human Skin
11%
Hydrolysis Kinetics
11%
Hydroxy Group
11%
Isopropyl Myristate
11%
Lipid Solubility
11%
Lipophilic
11%
Lipophilicity
11%
Morphine
100%
Octanol
11%
Partition Coefficient
11%
Penetration Property
22%
Prodrug
100%
Skin Penetration
22%
Skin Samples
11%
Steady-state Flux
11%
Transdermal Delivery
22%
Water Solubility
22%
Pharmacology, Toxicology and Pharmaceutical Science
Buffer
11%
Hydroxyl Group
11%
Lipophilicity
11%
Morphine
100%
Myristic Acid Isopropyl Ester
11%
Octanol
11%
Prodrug
100%
Receptor
11%
Transdermal
100%
Transdermal Delivery
22%