Usability of cerebrospinal fluid biomarkers in a tertiary memory clinic

C. Brandt; J.C. Bahl; N.H. Heegaard; G. Waldemar; P. Johannsen

Usability of cerebrospinal fluid biomarkers in a tertiary memory clinic

C. Brandt, J.C. Bahl, N.H. Heegaard, G. Waldemar, P. Johannsen

11 Citationer (Scopus)

Abstract

AIM: Assays for cerebrospinal fluid (CSF) levels of total tau, phospho-tau protein and beta-amyloid 1-42 have been available for some years. The aim of the study was to assess the usability of these biomarkers in a mixed population of tertiary dementia referral patients in a university-based memory clinic. METHODS: 147 consecutive patients with a lumbar puncture as a part of their clinical workup were studied. A retrospective diagnosis was established based on consensus criteria without the knowledge of the CSF results. RESULTS: When diagnosing Alzheimer's disease (AD) compared to other diagnoses, the sensitivity of a single abnormal value was between 33 and 66%. The specificity was high except when discriminating AD from amnestic mild cognitive impairment. Two or more abnormal markers further increased the specificity and decreased the sensitivity. CONCLUSION: In a tertiary setting, abnormal CSF biomarker results may be of a diagnostic value - whereas normal results do not exclude neurodegenerative disease
Udgivelsesdato: 2008

Originalsprog	Engelsk
Tidsskrift	Dementia and Geriatric Cognitive Disorders
Vol/bind	25
Udgave nummer	6
Sider (fra-til)	553-558
Antal sider	5
ISSN	1420-8008
Status	Udgivet - 2008

Citationsformater

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title = "Usability of cerebrospinal fluid biomarkers in a tertiary memory clinic",

abstract = "AIM: Assays for cerebrospinal fluid (CSF) levels of total tau, phospho-tau protein and beta-amyloid 1-42 have been available for some years. The aim of the study was to assess the usability of these biomarkers in a mixed population of tertiary dementia referral patients in a university-based memory clinic. METHODS: 147 consecutive patients with a lumbar puncture as a part of their clinical workup were studied. A retrospective diagnosis was established based on consensus criteria without the knowledge of the CSF results. RESULTS: When diagnosing Alzheimer's disease (AD) compared to other diagnoses, the sensitivity of a single abnormal value was between 33 and 66%. The specificity was high except when discriminating AD from amnestic mild cognitive impairment. Two or more abnormal markers further increased the specificity and decreased the sensitivity. CONCLUSION: In a tertiary setting, abnormal CSF biomarker results may be of a diagnostic value - whereas normal results do not exclude neurodegenerative disease Udgivelsesdato: 2008",

author = "C. Brandt and J.C. Bahl and N.H. Heegaard and G. Waldemar and P. Johannsen",

year = "2008",

language = "English",

volume = "25",

pages = "553--558",

journal = "Dementia and Geriatric Cognitive Disorders",

issn = "1420-8008",

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TY - JOUR

T1 - Usability of cerebrospinal fluid biomarkers in a tertiary memory clinic

AU - Brandt, C.

AU - Bahl, J.C.

AU - Heegaard, N.H.

AU - Waldemar, G.

AU - Johannsen, P.

PY - 2008

Y1 - 2008

N2 - AIM: Assays for cerebrospinal fluid (CSF) levels of total tau, phospho-tau protein and beta-amyloid 1-42 have been available for some years. The aim of the study was to assess the usability of these biomarkers in a mixed population of tertiary dementia referral patients in a university-based memory clinic. METHODS: 147 consecutive patients with a lumbar puncture as a part of their clinical workup were studied. A retrospective diagnosis was established based on consensus criteria without the knowledge of the CSF results. RESULTS: When diagnosing Alzheimer's disease (AD) compared to other diagnoses, the sensitivity of a single abnormal value was between 33 and 66%. The specificity was high except when discriminating AD from amnestic mild cognitive impairment. Two or more abnormal markers further increased the specificity and decreased the sensitivity. CONCLUSION: In a tertiary setting, abnormal CSF biomarker results may be of a diagnostic value - whereas normal results do not exclude neurodegenerative disease Udgivelsesdato: 2008

AB - AIM: Assays for cerebrospinal fluid (CSF) levels of total tau, phospho-tau protein and beta-amyloid 1-42 have been available for some years. The aim of the study was to assess the usability of these biomarkers in a mixed population of tertiary dementia referral patients in a university-based memory clinic. METHODS: 147 consecutive patients with a lumbar puncture as a part of their clinical workup were studied. A retrospective diagnosis was established based on consensus criteria without the knowledge of the CSF results. RESULTS: When diagnosing Alzheimer's disease (AD) compared to other diagnoses, the sensitivity of a single abnormal value was between 33 and 66%. The specificity was high except when discriminating AD from amnestic mild cognitive impairment. Two or more abnormal markers further increased the specificity and decreased the sensitivity. CONCLUSION: In a tertiary setting, abnormal CSF biomarker results may be of a diagnostic value - whereas normal results do not exclude neurodegenerative disease Udgivelsesdato: 2008

M3 - Journal article

SN - 1420-8008

VL - 25

SP - 553

EP - 558

JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

IS - 6

ER -