TY - JOUR
T1 - Urinary Proteomics and Precision Medicine for Chronic Kidney Disease
T2 - Current Status and Future Perspectives
AU - Persson, Frederik
AU - Rossing, Peter
N1 - Special Issue: Clinical Proteomics on the Way Towards Implementation
PY - 2019
Y1 - 2019
N2 - Precision medicine is since long an ongoing refinement of classical medicine, integrating improved and more detailed pathophysiological understanding with rapid technological advances. In the heterogenous area of chronic kidney disease there seems to be a high potential for the improvement in treatment and prognosis for several causes, with new technologies under development, that are yet to be introduced in clinical practice. As in other medical disciplines, investigation of abundant peptide patterns (proteomics) has gained recent interest. Especially relevant for kidney disease, urinary proteomics may provide both improved diagnosis and, as reviewed here, also holds promise for personalized treatment in the future. So far, capillary electrophoresis coupled to mass spectrometry (CE-MS) is the most widely applied technique, and in addition to several cross-sectional and cohort studies, there is even an ongoing randomized controlled trial that will soon report on the concept used as a method of personalizing treatment. In addition, there is hope that urinary proteomics can turn into a “liquid biopsy,” replacing the invasive diagnostic procedure. The next couple of years will provide more answers on the topic.
AB - Precision medicine is since long an ongoing refinement of classical medicine, integrating improved and more detailed pathophysiological understanding with rapid technological advances. In the heterogenous area of chronic kidney disease there seems to be a high potential for the improvement in treatment and prognosis for several causes, with new technologies under development, that are yet to be introduced in clinical practice. As in other medical disciplines, investigation of abundant peptide patterns (proteomics) has gained recent interest. Especially relevant for kidney disease, urinary proteomics may provide both improved diagnosis and, as reviewed here, also holds promise for personalized treatment in the future. So far, capillary electrophoresis coupled to mass spectrometry (CE-MS) is the most widely applied technique, and in addition to several cross-sectional and cohort studies, there is even an ongoing randomized controlled trial that will soon report on the concept used as a method of personalizing treatment. In addition, there is hope that urinary proteomics can turn into a “liquid biopsy,” replacing the invasive diagnostic procedure. The next couple of years will provide more answers on the topic.
KW - albuminuria
KW - chronic kidney disease
KW - diabetes
KW - glomerular filtration
KW - urinary proteomics
U2 - 10.1002/prca.201800176
DO - 10.1002/prca.201800176
M3 - Review
C2 - 30632676
AN - SCOPUS:85060523612
SN - 1862-8346
VL - 13
JO - Proteomics - Clinical Applications
JF - Proteomics - Clinical Applications
IS - 2
M1 - 1800176
ER -
