Uncoupling of cerebral blood flow and metabolism after single episode of cortical spreading depression in the rat brain

TY - JOUR

T1 - Uncoupling of cerebral blood flow and metabolism after single episode of cortical spreading depression in the rat brain

AU - Lauritzen, Martin

AU - Henrik Diemer, Niels

PY - 1986/4/9

Y1 - 1986/4/9

N2 - The present study was undertaken to evaluate whether the persistent hypoperfusion following cortical spreading depression (CSD) in rat brain was accompanied by alterations of regional cortical glucose consumption (rCGU). rCGU was measured using 2-deoxy-[14C]glucose and autoradiography at 15-60 min after single CSD episodes. rCGU did not differ in cortical regions invaded by CSD as compared to the contralateral side and to sham-treated rats. The results suggested impairment of the metabolism-flow couple after CSD.

AB - The present study was undertaken to evaluate whether the persistent hypoperfusion following cortical spreading depression (CSD) in rat brain was accompanied by alterations of regional cortical glucose consumption (rCGU). rCGU was measured using 2-deoxy-[14C]glucose and autoradiography at 15-60 min after single CSD episodes. rCGU did not differ in cortical regions invaded by CSD as compared to the contralateral side and to sham-treated rats. The results suggested impairment of the metabolism-flow couple after CSD.

KW - cerebral glucose consumption

KW - spreading depression

UR - http://www.scopus.com/inward/record.url?scp=0022506730&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(86)90504-4

DO - 10.1016/0006-8993(86)90504-4

M3 - Journal article

C2 - 3708336

AN - SCOPUS:0022506730

SN - 0006-8993

VL - 370

SP - 405

EP - 408

JO - Brain Research

JF - Brain Research

IS - 2

ER -