Tyrosine hydroxylase polymorphism (C-824T) and hypertension: a population-based study

TY - JOUR

T1 - Tyrosine hydroxylase polymorphism (C-824T) and hypertension: a population-based study

AU - Nielsen, Søren J

AU - Jeppesen, Jørgen Lykke

AU - Torp-Pedersen, Christian

AU - Hansen, Tine W

AU - Linneberg, Allan

AU - Fenger, Mogens

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Background Sympathetic nervous system (SNS) overactivity is present in a large proportion of the hypertensive population and precedes the development of established hypertension. Variations in the proximal promoter of the tyrosine hydroxylase (TH) gene have been shown to influence biochemical and physiological traits in the SNS as well as hypertension.Methods We investigated the relationship between a common single-nucleotide polymorphism (SNP) in the proximal TH promoter (C-824T) and blood pressure (BP) in a large general population sample, characterized by 24-h ambulatory BP (ABP) monitoring and office BP measurement. Results The study population consisted of 1,221 women and 1,182 men, ages 41-71 years, without major cardiovascular diseases. Regarding the C-824T SNP, 32.4% had the C/C genotype, 50.0% the C/T genotype, and 17.6% the T/T genotype. The T/T genotype conferred an ∼45% increase in relative risk of hypertension, defined by conventional criteria, compared with the C/C genotype, and participants with the T/T genotype had significantly higher mean (95% confidence interval (CI)) systolic BP (SBP) (138 (136-140) mmHg vs. 135 (133-136)), diastolic BP (DBP) (88 (86-89) mmHg vs. 85 (84-86)), and heart rate (68 (67-69) beats/min vs. 66 (65-67)) than participants with the C/C genotype (P<0.05). BP, heart rate, and prevalence of hypertension were intermediate in participants with the C/T genotype. These effects were the same in women and men and whether BP was measured in the office or by 24-h ambulatory monitoring.ConclusionThe C-824T SNP in the proximal TH promoter influences BP and prevalence of hypertension in the general population.

AB - Background Sympathetic nervous system (SNS) overactivity is present in a large proportion of the hypertensive population and precedes the development of established hypertension. Variations in the proximal promoter of the tyrosine hydroxylase (TH) gene have been shown to influence biochemical and physiological traits in the SNS as well as hypertension.Methods We investigated the relationship between a common single-nucleotide polymorphism (SNP) in the proximal TH promoter (C-824T) and blood pressure (BP) in a large general population sample, characterized by 24-h ambulatory BP (ABP) monitoring and office BP measurement. Results The study population consisted of 1,221 women and 1,182 men, ages 41-71 years, without major cardiovascular diseases. Regarding the C-824T SNP, 32.4% had the C/C genotype, 50.0% the C/T genotype, and 17.6% the T/T genotype. The T/T genotype conferred an ∼45% increase in relative risk of hypertension, defined by conventional criteria, compared with the C/C genotype, and participants with the T/T genotype had significantly higher mean (95% confidence interval (CI)) systolic BP (SBP) (138 (136-140) mmHg vs. 135 (133-136)), diastolic BP (DBP) (88 (86-89) mmHg vs. 85 (84-86)), and heart rate (68 (67-69) beats/min vs. 66 (65-67)) than participants with the C/C genotype (P<0.05). BP, heart rate, and prevalence of hypertension were intermediate in participants with the C/T genotype. These effects were the same in women and men and whether BP was measured in the office or by 24-h ambulatory monitoring.ConclusionThe C-824T SNP in the proximal TH promoter influences BP and prevalence of hypertension in the general population.

U2 - 10.1038/ajh.2010.165

DO - 10.1038/ajh.2010.165

M3 - Journal article

SN - 0895-7061

VL - 23

SP - 1306

EP - 1311

JO - American Journal of Hypertension

JF - American Journal of Hypertension

IS - 12

ER -