Typical Danish Caucasian type 2 diabetic patients do not commonly carry genetic variants in GIP and GLP-1 encoding regions of the proGIP and proglucagon genes

TY - JOUR

T1 - Typical Danish Caucasian type 2 diabetic patients do not commonly carry genetic variants in GIP and GLP-1 encoding regions of the proGIP and proglucagon genes

AU - Ørskov, Cathrine

AU - Hjorth, Siv A

AU - Jensen, Anne

AU - Vilsbøll, Tina

PY - 2004/7/15

Y1 - 2004/7/15

N2 - The enteroinsular-axis is abnormal in type 2 diabetics, which contributes to the diabetic phenotype. The effect of the incretin hormone gastric inhibitory polypeptide (GIP) and the secretion of the incretin hormone glucagon-like peptide-1 (GLP-1) are thus greatly diminished. The explanation for these changes could be changes in the structure of either of the hormones or their receptors. Thus, the aim of this study was to study the occurrence of genetic variants in the GIP and GLP-1 encoding regions of the proGIP and proglucagon genes in type 2 diabetic patients and matched control subjects.

AB - The enteroinsular-axis is abnormal in type 2 diabetics, which contributes to the diabetic phenotype. The effect of the incretin hormone gastric inhibitory polypeptide (GIP) and the secretion of the incretin hormone glucagon-like peptide-1 (GLP-1) are thus greatly diminished. The explanation for these changes could be changes in the structure of either of the hormones or their receptors. Thus, the aim of this study was to study the occurrence of genetic variants in the GIP and GLP-1 encoding regions of the proGIP and proglucagon genes in type 2 diabetic patients and matched control subjects.

U2 - http://dx.doi.org/10.1016/j.regpep.2004.03.007

DO - http://dx.doi.org/10.1016/j.regpep.2004.03.007

M3 - Journal article

SN - 0167-0115

VL - 119

SP - 151

EP - 154

JO - Regulatory Peptides

JF - Regulatory Peptides

IS - 3

ER -